Survival of head and neck cancer in Greenland

Jensen, Ramon Gordon; Friborg, Jeppe; Rosborg, Jørn; Specht, Lena; Brofeldt, Susanne; Therkildsen, Marianne Hamilton; Homøe, Preben
September 2010
International Journal of Circumpolar Health;2010, Vol. 69 Issue 4, p373
Academic Journal
Objectives. Head and neck cancer is frequent in the Inuit population of Greenland and is characterized by a very high incidence of Epstein-Barr virus associated nasopharyngeal carcinoma (NPC). However, information on the treatment and survival of Inuit head and neck cancer patients is practically non-existent. The aim of this study, therefore, was to analyse the epidemiological pattern, time course and survival of head and neck cancer patients in Greenland. Study design. Retrospective register-based study. Methods. The Danish Civil Registration System, the Danish Cancer Registry and hospital-based registries were used to identify all patients resident in Greenland diagnosed with head and neck cancer during the period 1994-2003. Data were analysed with regard to clinical characteristics, treatment delay and survival. Results. A total of 125 patients were identified. The age-standardized incidence rate for all head and neck cancer cases was 28/100,000 for males and 19/100,000 for females. High incidence rates were found for NPC and oral cancers. Of all cancers, 47% were stage IV at the time of diagnosis, while 61% of all NPC's were stage IV. The median delay from date of first symptom to treatment was 248 days for all cancers. The overall crude 5-year survival rate for all sites together was 35% and for NPC 20%. Conclusion. Survival of head and neck cancer in Greenland is very low. Delays in treatment and inadequate follow-up on treatment complications are probable causes. The improvements in treatment for NPC and other head and neck cancer cases over the last decades are yet to be seen in this Inuit population.


Related Articles

  • Epstein-Barr virus and Nasopharyngeal Carcinoma Risk in China.  // JNCI: Journal of the National Cancer Institute;9/19/2012, Vol. 104 Issue 18, pNP 

    The article discusses research on the link of tobacco smoke exposure to an elevated risk of nasopharyngeal carcinoma (NPC) as well as Epstein-Barr Virus (EBV) seropositivity in males. Researchers Wei-Hua Jia and colleagues of the Sun Yat-sen University Cancer Center in China used data from male...

  • Correlates of anti-EBV EBNA1 IgA positivity among unaffected relatives from nasopharyngeal carcinoma multiplex families. Chang, C M; Yu, K J; Hsu, W L; Major, J M; Chen, J Y; Lou, P J; Liu, M Y; Diehl, S R; Goldstein, A M; Chen, C J; Hildesheim, A // British Journal of Cancer;1/3/2012, Vol. 106 Issue 1, p206 

    Background:To determine whether non-viral nasopharyngeal carcinoma (NPC) risk factors might be associated with (and mediated through) Epstein-Barr virus (EBV) serological responses linked to NPC risk, we evaluated predictors of risk of anti-EBNA1 IgA seropositivity and other markers among...

  • Intensity-modulated radiotherapy with simultaneous modulated accelerated boost technique and chemotherapy in patients with nasopharyngeal carcinoma. Fareed, Muhammad M.; AlAmro, Abdullah S.; Bayoumi, Yasser; Tunio, Mutahir A.; Ismail, Abdul S.; Akasha, Rashad; Mubasher, Mohamed; Asiri, Mushabbab A. l. // BMC Cancer;2013, Vol. 13 Issue 1, p1 

    Background: To present our experience of intensity-modulated radiotherapy (IMRT) with simultaneous modulated accelerated radiotherapy (SMART) boost technique in patients with nasopharyngeal carcinoma (NPC). Methods: Sixty eight patients of NPC were treated between April 2006 and December 2011...

  • Viral double whammy triggers cancers. Weuthrich, Bernice // New Scientist;8/5/95, Vol. 147 Issue 1989, p17 

    Reports a discovery by US researchers of nasopharyngeal cancer being caused by Epstein-Barr virus (EBV). Chances that infection of Southern Chinese population with the disease may be due to genetic and dietary factors; Research on EBV virus and latent membrane protein 1 (LMP1); Role of EBV in...

  • Exosomal HIF1α supports invasive potential of nasopharyngeal carcinoma-associated LMP1-positive exosomes. Aga, M; Bentz, G L; Raffa, S; Torrisi, M R; Kondo, S; Wakisaka, N; Yoshizaki, T; Pagano, J S; Shackelford, J // Oncogene;9/11/2014, Vol. 33 Issue 37, p4613 

    It has emerged recently that exosomes are potential carriers of pro-tumorigenic factors that participate in oncogenesis. However, whether oncogenic transcription factors are transduced by exosomes is unknown. Hypoxia-inducible factor-1α (HIF1α) transcriptionally regulates numerous key...

  • Treatment of Nasopharyngeal Carcinoma: Therapeutic Management and Future View of Epstein-Barr Virus-Targeting Treatment. Murono, Shigeyuki; Kondo, Satoru; Wakisaka, Naohiro; Yoshizaki, Tomokazu // Current Cancer Therapy Reviews;2009, Vol. 5 Issue 3, p170 

    Nasopharyngeal carcinoma (NPC) is a highly invasive and metastatic tumor, which is universally associated with Epstein-Barr virus (EBV). Clinically, radiotherapy, but not surgery, is usually performed for the treatment of NPC because of the deep and complex location of the tumor. Previous...

  • Epstein-Barr Virus Infection and Sporadic Breast Cancer Risk: A Meta-Analysis. Qiang Huo; Ning Zhang; Qifeng Yang // PLoS ONE;Feb2012, Vol. 7 Issue 2, p1 

    Background: A large number of epidemiological studies have evaluated the association between Epstein-Barr virus infection and breast carcinoma risk but results have been inconsistent. Methodology: Research using the polymerase chain reaction technique for detecting the Epstein-Barr virus was...

  • DNA double-strand break repair capacity and risk of breast cancer. Da-Tian Bau; Yi-Chien Mau; Shian-ling Ding; Pei-Ei Wu; Chen-Yang Shen // Carcinogenesis;Aug2007, Vol. 28 Issue 8, p1726 

    A tumorigenic role of the non-homologous end-joining (NHEJ) pathway for the repair of DNA double-strand breaks (DSBs) has been suggested by our finding of a significant association between increased breast cancer risk and a cooperative effect of single-nucleotide polymorphisms in NHEJ genes. To...

  • Non-Hodgkin lymphoma in pediatric patients with common variable immunodeficiency. Piquer Gibert, Monica; Alsina, Laia; Giner Muñoz, María; Cruz Martínez, Ofelia; Ruiz Echevarria, Karen; Dominguez, Olga; Plaza Martín, Ana; Arostegui, Juan; Valles, Guillem; Juan Otero, Manel; Martin-Mateos, Maria // European Journal of Pediatrics;Aug2015, Vol. 174 Issue 8, p1069 

    Common variable immunodeficiency (CVID) is a heterogeneous primary immunodeficiency associated with an increased risk of malignancy in adulthood, with lymphoma as one of the major causes of death. The aim of this study is to describe those malignancies detected in our cohort of pediatric CVID...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics