TITLE

In Silico Identification of Potential American Cockroach (Periplaneta americana) Allergens

AUTHOR(S)
Ahmed, A.; Minhas, K.; Aftab, O.; Sher Khan, F.
PUB. DATE
September 2010
SOURCE
Iranian Journal of Public Health;2010, Vol. 39 Issue 3, p109
SOURCE TYPE
Periodical
DOC. TYPE
Article
ABSTRACT
Background: Cockroaches have been recognized as a powerful indoor allergen. Cockroach allergy can be a major factor in serious asthma and nasal allergy. Bioinformatics tools have been developed to identify potential allergens. The present study was conducted to identify potential allergens in Periplaneta americana (Linnaeus). Methods: The study focused on the identification of potential allergens among the characterized proteins of P. americana using web-based and publicly available allergen prediction tools that follow the FAO/WHO guidelines for prediction of allergenic proteins. P. americana protein sequences were retrieved from UniProtKB. The sequences obtained were analyzed using AlgPred. The potential allergens obtained were further analyzed by SDAP for confirmation. Results: Protein sequences (233 cases) of P. americana were obtained from UniProtKB out of which 25 were known allergens. Out of the remaining 208 proteins, 102 potential allergens were predicted by AlgPred. However, only 9 were found to be potential allergens after screening with SDAP. Arginine kinases, RNA polymerase II subunit, parcxpwnx02, peptidylprolyl cis-trans isomerase, hemocyanin subunit type I and type II, homologue of Sarcophaga proteinase and alpha amylase were confirmed to be potential allergens by SDAP. Conclusion: We have identified nine potential allergens in P. americana that may be used as preliminary support for further laboratory experiments.
ACCESSION #
53899827

 

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