TITLE

Effect of chronic administration of green tea extract on chemically induced electrocardiographic and biochemical changes in rat heart

AUTHOR(S)
Patil, Leena J.; Bothara, Sunil B.; R., Balaraman
PUB. DATE
July 2010
SOURCE
International Journal of Green Pharmacy (Medknow Publications & ;Jul-Sep2010, Vol. 4 Issue 3, p170
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Many chemicals induce cell-specific cytotoxicity. Chemicals like doxorubicin induce oxidative stress leading to cardiotoxicity causing abnormalities in ECG and increase in the biomarkers indicating toxicity. Green tea extract (GTE), Camellia sinensis (Theaceae), is reported to exert antioxidant activity mainly by means of its polyphenolic constituent, catechins. Our study was aimed to find out the effect of GTE (25, 50, 100 mg/kg/day p.o. for 30 days) on doxorubicin-induced (3 mg/kg/week, i.p. for 5 weeks) electrocardiographic and biochemical changes in rat heart. It is observed that GTE administered rats were less susceptible to doxorubicin-induced electrocardiographic changes and changes in biochemical markers like lactate dehydrogenase (LDH), creatine kinase (CK), and glutamic oxaloacetate transaminase (GOT) in serum, and superoxide dismutase (SOD), catalase (CAT) and reduced glutathione (GSH), membrane bound enzymes like Na+K+ATPase, Ca2+ ATPase, Mg2+ ATPase and decreased lipid peroxidation (LP) in heart tissue, indicating the protection afforded by GTE administration.
ACCESSION #
53889617

 

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