Coincidental finding of Fabry’s disease in a patient with IgA nephropathy

Kakita, Tomoko; Nagatoya, Katsuyuki; Mori, Tatsuhiko; Kobayashi, Masahisa; Inoue, Toru
October 2010
NDT Plus;Oct2010, Vol. 3 Issue 5, p443
Academic Journal
We present the case of a woman with IgA nephropathy and concomitant Fabry’s disease. She was referred to our hospital with proteinuria and haematuria. A renal biopsy showed findings indicating IgA nephropathy under light and immunofluorescence microscopy. Electron microscopy, however, showed laminated inclusion bodies characteristic of Fabry’s disease. The α-galactosidase activity in her serum was low, and the diagnosis of Fabry’s disease was confirmed by genetic analysis. Fabry’s disease in a patient with IgA nephropathy is a very rare occurrence, and Fabry’s disease diagnosed only by electron microscopy has not been previously reported.


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