TITLE

Bio-sensing using recessed gold-filled capillary amperometric electrodes

AUTHOR(S)
Kacanovska, A.; Rong, Z.; Schmidt, M.; Russell, P. St. J.; Vadgama, P.
PUB. DATE
October 2010
SOURCE
Analytical & Bioanalytical Chemistry;Oct2010, Vol. 398 Issue 4, p1687
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
novel recessed electrode is reported for amperometric detection of hydrogen peroxide and via glucose oxidase for the detection of glucose. The electrode utilised electrodeposited platinum over a gold wire surface, which proved to be an effective peroxide-detecting surface. Compared with a traditional exposed electrode surface, the recessed tip facilitated an extended linear range for glucose from 4 to over 14 mM. Bio-fouling, as assessed by exposure to bovine serum albumin, was also significantly reduced. Though response time at the recess was increased, it was within an acceptable range for physiological monitoring. Moreover, the recess enabled precise measurement of the hydrogen peroxide diffusion coefficient; this was based on a bipartite expression for the transient amperometric current at the recessed structure following a step change in ambient hydrogen peroxide concentration. An important aspect of the diffusion measurement was the curve fitting routine used to map on to the theoretical response curve. [Figure not available: see fulltext.]
ACCESSION #
53840419

 

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