Digital biosensors with built-in logic for biomedical applications-biosensors based on a biocomputing concept

Wang, Joseph; Katz, Evgeny
October 2010
Analytical & Bioanalytical Chemistry;Oct2010, Vol. 398 Issue 4, p1591
Academic Journal
This article reviews biomolecular logic systems for bioanalytical applications, specifically concentrating on the prospects and fundamental and practical challenges of designing digitally operating biosensors logically processing multiple biochemical signals. Such digitally processed information produces a final output in the form of a yes/no response through Boolean logic networks composed of biomolecular systems, and hence leads to a high-fidelity biosensing compared with traditional single (or parallel) sensing devices. It also allows direct coupling of the signal processing with chemical actuators to produce integrated 'smart' 'sense/act' (biosensor-bioactuator) systems. Unlike common biosensing devices based on a single input (analyte), devices based on biochemical logic systems require a fundamentally new approach for the sensor design and operation and careful attention to the interface of biocomputing systems and electronic transducers. As common in conventional biosensors, the success of the enzyme logic biosensor would depend, in part, on the immobilization of the biocomputing reagent layer. Such surface confinement provides a contact between the biocomputing layer and the transducing surface and combines efficiently the individual logic-gate elements. Particular attention should thus be given to the composition, preparation, and immobilization of the biocomputing surface layer, to the role of the system scalability, and to the efficient transduction of the output signals. By processing complex patterns of multiple physiological markers, such multisignal digital biosensors should have a profound impact upon the rapid diagnosis and treatment of diseases, and particularly upon the timely detection and alert of medical emergencies (along with immediate therapeutic intervention). Other fields ranging from biotechnology to homeland security would benefit from these advances in new biocomputing biosensors and the corresponding closed-loop 'add/act' operation. [Figure not available: see fulltext.]


Related Articles

  • Editorial. Saida, Fakhri // Protein & Peptide Letters;Aug2008, Vol. 15 Issue 8, p756 

    The article discusses various reports published within the issue, including one by B. Prieto-Simon et al. on the main biomolecules immobilization strategies and another by D. Zhang et al. on the design of protein-based voltammetric biosensors fabricated with nanomaterials.

  • Hotwiring biosensors. Klemic, James F.; Stern, Eric; Reed, Mark A. // Nature Biotechnology;Oct2001, Vol. 19 Issue 10, p924 

    Studies the conductance behavior of nanofabricated doped silicon wires functionalized with organic molecules and biomolecules. Basic structure of the biosensor; Ways to demonstrate four different prototype sensors; Developments in nanofabrication techniques.

  • Recent Advances in the Fabrication and Application of Screen-Printed Electrochemical (Bio)Sensors Based on Carbon Materials for Biomedical, Agri-Food and Environmental Analyses. Hughes, Gareth; Westmacott, Kelly; Honeychurch, Kevin C.; Crew, Adrian; Pemberton, Roy M.; Hart, John P. // Biosensors (2079-6374);Dec2016, Vol. 6 Issue 4, p1 

    This review describes recent advances in the fabrication of electrochemical (bio)sensors based on screen-printing technology involving carbon materials and their application in biomedical, agri-food and environmental analyses. It will focus on the various strategies employed in the fabrication...

  • Co-existence of the occupied and vacant phase in Boolean models in three or more dimensions. Sarkar, Anish // Advances in Applied Probability;Dec97, Vol. 29 Issue 4, p878 

    Examines the occupied and vacant regions in Boolean models containing unbounded components. Use of the concept of enhancement; Description of the model of continuum percolation; Definition of the vacant and occupied regions.

  • A Boolean Approach to Linear Prediction for Signaling Network Modeling. Eduati, Federica; Corradin, Alberto; Di Camillo, Barbara; Toffolo, Gianna // PLoS ONE;2010, Vol. 5 Issue 9, p1 

    The task of the DREAM4 (Dialogue for Reverse Engineering Assessments and Methods) ''Predictive signaling network modeling'' challenge was to develop a method that, from single-stimulus/inhibitor data, reconstructs a cause-effect network to be used to predict the protein activity level in...

  • Enzymatic Logic Gates with Noise-Reducing Sigmoid Response. Pedrosa, Valber; Melnikov, Dmitriy; Pita, Marcos; HalĂ©mek, Jan; Privman, Vladimir; Simonian, Aleksandr; Katz, Evgeny // International Journal of Unconventional Computing;2010, Vol. 6 Issue 6, p451 

    Biochemical computing is an emerging field of unconventional computing that attempts to process information with biomolecules and biological objects using digital logic. In this work we survey filtering in general, in biochemical computing, and summarize the experimental realization of an AND...

  • Maximum Correlation Analysis of Nonlinear Combining Functions in Stream Ciphers. Muxiang Zhang // Journal of Cryptology;2000, Vol. 13 Issue 3, p301 

    The maximum correlation of a Boolean function to all Boolean functions of a subset of its input variables is investigated. A relationship is derived between the maximum correlation and the mutual information between the output of a balanced Boolean function and a subset of its random input...

  • On Polynomial Approximation of the Discrete Logarithm and the Diffie--Hellman Mapping. Coppersmith, Don; Shparlinski, Igor // Journal of Cryptology;2000, Vol. 13 Issue 3, p339 

    We obtain several lower bounds, exponential in terms of lg p, on the degrees of polynomials and algebraic functions coinciding with values of the discrete logarithm modulo a prime p at sufficiently many points; the number of points can be as little as p[sup1/2+e]. We also obtain improved lower...

  • Gaps in the Cardinalities of Row Spaces of Boolean Matrices. Hong Shaofang // Semigroup Forum;1998, Vol. 56 Issue 2, p158 

    In this paper we study the cardinalities of row spaces of Boolean matrices. We obtain the following main results: For the cardinalities of row spaces of Boolean matrices of order n, if n =8; then 2[supn 1] - k, where k = 1,2,3, are gaps; if n = 7, then 2[supn 1] -k, where k = 1,3, are gaps. This...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics