TITLE

Nervous System Effects of Antituberculosis Therapy

AUTHOR(S)
Kass, Joseph S.; Shandera, Wayne X.
PUB. DATE
August 2010
SOURCE
CNS Drugs;2010, Vol. 24 Issue 8, p655
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Nervous system toxicity with current antituberculosis pharmacotherapy is relatively uncommon, although the frequency of the usage of anti-tuberculosis therapy requires that physicians be aware of such toxicity. Anti-tuberculosis therapy manifests both central and peripheral nervous system effects, which may compromise patient compliance. Among the traditional forms of first-line antituberculosis therapy, isoniazid is most often associated with nervous system effects, most prominently peripheral neuropathy, psychosis and seizures. Adverse events are reported with other antituberculosis therapies, the most prominent being optic neuropathy with ethambutol and ototoxicity and neuromuscular blockade with aminoglycosides. The second-line agent with the most adverse effects is cycloserine, with psychosis and seizures, the psychosis in particular limiting its usage. Fluoroquinolones are rare causes of seizures and delirium, Newer forms of therapy are under development, but to date no significant neurotoxicity is documented with these agents. Future needs include the development of surveillance mechanisms to increase recognition of nervous system toxicities. It is also hoped that the development of new pharmacogenomic assays will help with the identification of patients at risk for these toxicities.
ACCESSION #
53791206

 

Related Articles

  • Personal View. O'Riordan, J.E.G. // British Medical Journal (Clinical Research Edition);6/4/1988, Vol. 296 Issue 6636, p1599 

    Relates the experience of the author with the neurological disorder called spasmodic torticollis. Symptoms of the disease; Absence of definite explanation on the cause of spasmodic torticollis; Determination of the author to undergo treatment despite limited success of previous medications.

  • Understanding schizophrenia. Rigby, Paul; Alexander, James // Nursing Standard;3/19/2008, Vol. 22 Issue 28, p49 

    This article provides an introduction to schizophrenia, outlining its signs and symptoms, causes and possible prognosis for patients. It also considers a range of therapeutic approaches to treatment.

  • Fatal toxicity of drugs used in the treatment of psychotic illnesses. Buckley, Nicholas; McManus, Peter; Buckley, N; McManus, P // British Journal of Psychiatry;Jun98, Vol. 172, p461 

    The authors reflect on the importance of the calculation of fatal toxicity index (FTI) of drugs in the treatment of psychotic illnesses. They state that knowing the FTI of drugs such as antidepressants and benzodiazepines could help minimize the risk of self-poisoning and suicide. They stress...

  • Isoniazid- and ethambutol-induced psychosis. R., Prasad; Garg, Rajiv; Verma, Sanjay Kumar // Annals of Thoracic Medicine;Oct2008, Vol. 3 Issue 4, p149 

    Most cases of antituberculous agent-associated psychoses were caused by isoniazid (INH), with ethambutol (EMB)-induced psychosis being rare. The concomitant occurrence of INH- and EMB- induced psychosis and in a single individual is extremely uncommon. We report a case of 28-year-old male who...

  • Antituberculars.  // Reactions Weekly;Feb2015, Vol. 1540 Issue 1, p40 

    The article presents a case study of a 42-year-old man who developed psychosis and peripheral neuropathy, during treatment with antitubercular agents, including cycloserine, ethambutol, and levofloxacin, for multidrug-resistant tuberculosis (MDR-TB).

  • Continuing Education Course #3: Current Practices and Future Trends in Neuropathology Assessment for Developmental Neurotoxicity Testing. Bolon, Brad; Garman, Robert H.; Gundersen, Hans Jørgen G.; Allan Johnson, G.; Kaufmann, Wolfgang; Krinke, Georg; Little, Peter B.; Makris, Susan L.; Mellon, R. Daniel; Sulik, Kathleen K.; Jensen, Karl // Toxicologic Pathology;1/1/2011, Vol. 39 Issue 1, p289 

    The continuing education course on Developmental Neurotoxicity Testing (DNT) was designed to communicate current practices for DNT neuropathology, describe promising innovations in quantitative analysis and noninvasive imaging, and facilitate a discussion among experienced neuropathologists and...

  • Pharmacovigilance and tuberculosis: applying the lessons of thioacetazone. Falzon, Dennis; Hill, Geraldine; Pal, Shanthi N.; Suwankesawong, Wimon; Jaramillo, Ernesto // Bulletin of the World Health Organization;Dec2014, Vol. 92 Issue 12, p918 

    In this article the authors discuss pharmacovigilance and its relationship to tuberculosis. They are supportive of monitoring the production and utilization of newly developed tuberculosis drugs which are designed to fight against drug-resistant tuberculosis to ensure public safety and avoid...

  • Three allele combinations associated with Multiple Sclerosis. Favorova, Olga O; Favorov, Alexander V; Boiko, Alexey N; Andreewski, Timofey V; Sudomoina, Marina A; Alekseenkov, Alexey D; Kulakova, Olga G; Gusev, Eugenyi I; Parmigiani, Giovanni; Ochs, Michael F // BMC Medical Genetics;2006, Vol. 7, p63 

    Background: Multiple sclerosis (MS) is an immune-mediated disease of polygenic etiology. Dissection of its genetic background is a complex problem, because of the combinatorial possibilities of gene-gene interactions. As genotyping methods improve throughput, approaches that can explore...

  • Diseases of the nervous system: patient's aetiological beliefs. Croquelois, A.; Assal, G.; Annoni, J-M.; Staub, F.; Gronchi, A.; Bruggimann, L.; Dieguez, S.; Bogousslavsky, J. // Journal of Neurology, Neurosurgery & Psychiatry;Apr2005, Vol. 76 Issue 4, p582 

    Background: Patients' opinions about the aetiology of their disease and the implications for compliance have not been well documented at this time. Objective: To investigate prospectively aetiological beliefs of a cohort of neurological inpatients. Methods: Within two days of admission, patients...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics