In Search of Safer NSAIDs: Which Cause the Least Risk of Upper GI Bleeding?

Scherger, Joseph E.
August 2010
Internal Medicine Alert;8/15/2010, Vol. 32 Issue 15, p115
A systematic review of 9 studies showed that the COX-2 inhibitor celecoxib and ibufrofen cause less upper GI bleeding than other NSAIDs. Diclofenac meloxicam, ketoprofen, indomethacin, and naproxen have intermediate risk. Piroxicam and ketorolac have the highest risk. In general, drugs that have a long half-life or slow-release formulation have the greatest risk of GI bleeding.


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