Blood flow velocity imaging of malignant melanoma by micro multipoint laser Doppler velocimetry

Ishida, H.; Andoh, T.; Akiguchi, S.; Shirakawa, H.; Kobayashi, D.; Kuraishi, Y.; Hachiga, T.
September 2010
Applied Physics Letters;9/6/2010, Vol. 97 Issue 10, p103702
Academic Journal
We have developed a laser Doppler velocimeter to measure blood flow, the micromultipoint laser Doppler velocimeter (μ-MLDV). This equipment can measure absolute velocity and, based on this, can display the course of blood vessels. In this study, we attempted to perform blood flow velocity imaging of malignant melanoma transplanted to the mouse ear. We found that blood flow velocity of the formed blood vessels originating in the melanoma was much greater than that of the capillary vessels in normal skin. Furthermore, the form of the tumor was clearly visible from the blood flow velocity image. These experimental results suggest that μ-MLDV has potential as a diagnostic method for distinguishing benign nevi from malignant melanomas.


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