3-[[sup 123] I]Iodo-α-methyl-L-tyrosine uptake in cerebral gliomas: relationship to histological grading and prognosis

Schmidt, Daniela; Gottwald, Ullrich; Langen, Karl-Josef; Weber, Friedrich; Hertel, Anja; Floeth, Frank; Felsberg, Jörg; Reifenberger, Guido; Coenen, Heinz H.; Müller-Gärtner, Hans-Wilhelm
July 2001
European Journal of Nuclear Medicine;2001, Vol. 28 Issue 7, p855
Academic Journal
3-[[sup 123] I]Iodo-α-methyl-L-tyrosine (IMT) is employed clinically as a tracer of amino acid transport in brain tumours using single-photon emission tomography (SPET). This study investigates the role of IMT SPET in the non-invasive histological grading and prognostic evaluation of cerebral gliomas. The files of patients investigated by IMT SPET in our clinic between 1988 and 1996 were evaluated retrospectively. Complete follow-up was available for 58 patients with cerebral gliomas investigated by IMT SPET shortly after tumour diagnosis. Seventeen patients had low-grade gliomas (WHO grade II), 14 had anaplastic gliomas (WHO grade III) and 27 had glioblastomas (WHO grade IV). Thirty-six cases were primary tumours and 22 cases, recurrences. Maximal and mean tumour-to-brain (T/B) ratios of IMT uptake at the first IMT SPET investigation were related to histological grading and survival time. Patients with low-grade gliomas showed significantly longer survival than patients with high-grade (grade III or IV) tumours. Gliomas without contrast enhancement on computed tomography or magnetic resonance imaging scans were associated with longer patient survival than tumours with contrast enhancement. The T/B ratios of IMT SPET showed no differences in relation to histological grading [WHO grade II: 1.73±0.59; WHO grade III: 1.74±0.38; WHO grade IV: 1.59±0.35, (mean±SD, T/B ratios of mean tumour uptake)]. The median survival time of patients with a high T/B ratio on IMT SPET was not significantly different from that of patients with a low T/B ratio (T/B ratio <1.6, 14.8 months; T/B ratio ≥1.6, 13.0 months). Thus, no evidence could be found for a relationship between IMT uptake in cerebral gliomas and either histological grading or survival time. Nevertheless, IMT SPET constitutes a useful method for the detection of primary and recurrent gliomas, determination of tumour extent and individual follow-up.


Related Articles

  • Non-invasive grading of primary brain tumours: results of a comparative study between SPET with [sup 123] I-α-methyl tyrosine and PET with [sup 18] F-deoxyglucose. Woesler, Burkhard; Kuwert, Torsten; Morgenroth, Carlo; Matheja, Peter; Palkovic, Stefan; Schäfers, Michael; Vollet, Bernhard; Schäfers, Klaus; Lerch, Hartmut; Brandau, Wolfgang; Samnick, Samuel; Wassmann, Hansdetlef; Schober, Otmar // European Journal of Nuclear Medicine;1997, Vol. 24 Issue 4, p428 

    Use of iodine-123-α-methyl tyrosine ([sup 123]IIMT) allows investigation of the amino acid transport rate in gliomas. It was the aim of this study to compare the value of measurement of glucose metabolism with that of measurement of [sup 123]I-IMT uptake for the non-invasive grading of brain...

  • Localisation of motor areas in brain tumour patients: a comparison of preoperative [[sup 18] F]FDG-PET and intraoperative cortical electrostimulation. Schreckenberger, Mathias; Spetzger, Uwe; Sabri, Osama; Meyer, Philipp T.; Zeggel, Thomas; Zimny, Michael; Gilsbach, Joachim; Buell, Udalrich // European Journal of Nuclear Medicine;2001, Vol. 28 Issue 9, p1394 

    Assessment of the exact spatial relation between tumour and adjacent functionally relevant brain areas is a primary tool in the presurgical planning in brain tumour patients. The purpose of this study was to compare a preoperative fluorine-18 fluorodeoxyglucose positron emission tomography...

  • Preoperative mapping of cortical language areas in adult brain tumour patients using PET and individual non-normalised SPM analyses. Meyer, Philipp T.; Sturz, Laszlo; Schreckenberger, Mathias; Spetzger, Uwe; Meyer, Georg F.; Setani, Keyvan S.; Sabri, Osama; Buell, Udalrich // European Journal of Nuclear Medicine & Molecular Imaging;2003, Vol. 30 Issue 7, p951 

    In patients scheduled for the resection of perisylvian brain tumours, knowledge of the cortical topography of language functions is crucial in order to avoid neurological deficits. We investigated the applicability of statistical parametric mapping (SPM) without stereotactic normalisation for...

  • Brain tumour imaging with carbon-11 choline: comparison with FDG PET and gadolinium-enhanced MR imaging. Ohtani, Toshiyuki; Kurihara, Hideyuki; Ishiuchi, Shogo; Saito, Nobuhito; Oriuchi, Noboru; Inoue, Tomio; Sasaki, Tomio // European Journal of Nuclear Medicine;2001, Vol. 28 Issue 11, p1664 

    The purpose of this study was to assess the clinical potential of methyl-[sup 11] C-choline ([sup 11] C-choline) in the diagnosis of brain tumours. To this end, the results of [sup 11] C-choline positron emission tomography (PET) in 22 patients suspected of having brain tumours were compared...

  • Relationship between thallium-201 kinetics and proliferative activity assessed by monoclonal antibody MIB-1 in brain tumours. Motoyama, K.; Suga, K.; Kume, N.; Hara, A.; Ishikawa, Y.; Matsunaga, N.; Nishizaki, T. // European Journal of Nuclear Medicine;2001, Vol. 28 Issue 10, p1471 

    To clarify the relationship between thallium-201 chloride kinetics and proliferative activity in brain tumours, a single-photon emission tomographic (SPET) study was performed and the results correlated with monoclonal antibody MIB-1 staining of the tumour tissue. [sup 201] Tl SPET was performed...

  • PET/CT Frequently Changes Brain Tumor Treatment.  // Radiology Today;Mar2012, Vol. 13 Issue 3, p49 

    The article discusses the research conducted by Johannes Czernin and fellow researchers that proves the benefits of using positron emission tomography/ computerized tomography (PET/CT) for imaging amino acid transporters in patients with brain tumors. The study proves that images obtained by...

  • High uptake of L-3-[[sup 123] I]iodo-α-methyl tyrosine in pilocytic astrocytomas. Weckesser, Matthias; Matheja, Peter; Rickert, Christian H.; Sträter, Ronald; Palkovic, Stefan; Löttgen, Jan; Kurlemann, Gerd; Paulus, Werner; Wassmann, Hansdetlef; Schober, Otmar // European Journal of Nuclear Medicine;2001, Vol. 28 Issue 3, p273 

    Abstract. Despite a favourable prognosis, pilocytic astrocytomas may exhibit signs of malignancy on various neuroimaging modalities. This retrospective analysis was conducted to determine whether scintigraphic features of malignancy are also found on single-photon emission tomography (SPET)...

  • Imaging F-fluorodeoxy glucose/C-methionine uptake decoupling for identification of tumor cell infiltration in peritumoral brain edema. Kinoshita, Manabu; Goto, Tetsu; Arita, Hideyuki; Okita, Yoshiko; Isohashi, Kayako; Kagawa, Naoki; Fujimoto, Yasunori; Kishima, Haruhiko; Shimosegawa, Eku; Saitoh, Youichi; Hatazawa, Jun; Hashimoto, Naoya; Yoshimine, Toshiki // Journal of Neuro-Oncology;Jan2012, Vol. 106 Issue 2, p417 

    Discriminating tumor infiltrative and vasogenic brain edema in malignant gliomas is important although challenging in clinical settings. This study challenged this issue by performing voxel-wise analysis of F-fluorodeoxy glucose (FDG) and C-methionine positron emission tomography (PET) in...

  • 11C-Acetate PET in the Evaluation of Brain Glioma: Comparison with 11C-Methionine and 18F-FDG-PET. Y. Yamamoto; Y. Nishiyama; N. Kimura; R. Kameyama; N. Kawai; T. Hatakeyama; M. Kaji; M. Ohkawa // Molecular Imaging & Biology;Sep2008, Vol. 10 Issue 5, p281 

    Abstract Purpose  The aim of the study is to retrospectively investigate the usefulness of 11C-acetate (ACE)-positron emission tomography (PET) for evaluation of brain glioma, in comparison with 11C-methionine (MET) and 2-deoxy-2-18F-fluoro-d-glucose (FDG). ...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics