TITLE

Burden of paediatric Rotavirus Gastroenteritis (RVGE) and potential benefits of a universal Rotavirus vaccination programme with a pentavalent vaccine in Spain

AUTHOR(S)
Diez-Domingo, Javier; Suriñach, Nuria Lara; Alcalde, Natalia Malé; Betegón, Lourdes; Largeron, Nathalie; Trichard, Mélanie
PUB. DATE
January 2010
SOURCE
BMC Public Health;2010, Vol. 10, p469
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Rotavirus is the most common cause of gastroenteritis in young children worldwide. The aim of the study was to assess the health outcomes and the economic impact of a universal rotavirus vaccination programme with RotaTeq, the pentavalent rotavirus vaccine, versus no vaccination programme in Spain. Methods: A birth cohort was followed up to the age of 5 using a cohort model. Epidemiological parameters were taken from the REVEAL study (a prospective epidemiological study conducted in Spain, 2004-2005) and from the literature. Direct and indirect costs were assessed from the national healthcare payer and societal perspectives by combining health care resource utilisation collected in REVEAL study and unit costs from official sources. RotaTeq per protocol efficacy data was taken from a large worldwide rotavirus clinical trial (70,000 children). Health outcomes included home care cases, General Practioner (GP)/Paediatrician, emergency department visits, hospitalisations and nosocomial infections. Results: The model estimates that the introduction of a universal rotavirus vaccination programme with RotaTeq (90% coverage rate) would reduce the rotavirus gastroenteritis (RVGE) burden by 75% in Spain; 53,692 home care cases, 35,187 GP/Paediatrician visits, 34,287 emergency department visits, 10,987 hospitalisations and 2,053 nosocomial infections would be avoided. The introduction of RotaTeq would avoid about 76% of RVGE-related costs from both perspectives: ϵ22 million from the national health system perspective and ϵ38 million from the societal perspective. Conclusions: A rotavirus vaccination programme with RotaTeq would reduce significantly the important medical and economic burden of RVGE in Spain.
ACCESSION #
53413073

 

Related Articles

  • Rotavirus is top cause of child gastroenteritis. Mayor, Susan // GP: General Practitioner;5/18/2007, p12 

    The article reports on the findings of the European study, which examined 2,846 children who required medical treatment for acute gastroenteritis in primary care, emergency departments and hospital settings. The study found that most cases of gastroenteritis in children are caused by rotavirus....

  • Incidence of rotavirus infection in children with gastroenteritis attending Jos university teaching hospital, Nigeria. Junaid, Surajudeen A.; Umeh, Chijioke; Olabode, Atanda O.; Banda, Jim M. // Virology Journal;2011, Vol. 8 Issue 1, p1 

    This study was conducted to determine the incidence of rotavirus infection in children with gastroenteritis attending Jos university teaching hospital, Plateau State. A total of 160 children with acute diarrhea were selected by random sampling. Stool samples were obtained and assayed for...

  • Rotavirus Vaccine RIX4414 (Rotarix). Keating, Gillian M. // Pediatric Drugs;2006, Vol. 8 Issue 6, p389 

    â–´ RIX4414 is a human, live attenuated rotavirus vaccine containing a rotavirus strain of G1P[8] specificity; it is administered orally using a two-dose schedule. â–´ RIX4414 showed good immunogenicity in healthy infants in several well designed trials in terms of both seroconversion...

  • EVALUATION OF A ROTAVIRUS ACUTE GASTROENTERITIS SEVERITY SCORE IN HOSPITALIZED CHILDREN OVER A TEN YEAR PERIOD IN A CLINIC OF INFECTIOUS DISEASES, SKOPJE, R. MACEDONIA. Stojkovska, Snezana; Joksimovic, Blagica; Vidinic, Ivan; Trajkovska-Dokic, Elena // Contributions of Macedonian Academy of Sciences & Arts;Sep2013, Vol. 34 Issue 2, p23 

    Rotavirus infection is the most common viral infection of the gastrointestinal tract in children with the most severe clinical manifestations and rapidly progressive dehydration, especially in infancy and early childhood. Due to its characteristics of high contagiousness and being widespread in...

  • Evaluación del impacto económico de la vacuna antirrotavírica en Venezuela. Constela, Dagna; Pérez-Schael, Irene; Rheingans, Richard D.; Antil, Lynn; Salas, Hans; Yarzábal, Juan Pablo // Revista Panamericana de Salud Publica;Oct2006, Vol. 20 Issue 4, p213 

    Objective. To assess the cost of medical care for rotavirus gastroenteritis and the cost-effectiveness of the antiretroviral vaccine in Venezuelan children under five. Methods. We used an economic model that comprises epidemiologic information, vaccine efficacy, and the cost of medical care in...

  • Primary care-based surveillance to estimate the burden of rotavirus gastroenteritis among children aged less than 5 years in six European countries. Diez-Domingo, Javier; Baldo, Jose-Maria; Patrzalek, Marian; Pazdiora, Petr; Forster, Johannes; Cantarutti, Luigi; Pirçon, Jean-Yves; Soriano-Gabarró, Montse; Meyer, Nadia // European Journal of Pediatrics;Feb2011, Vol. 170 Issue 2, p213 

    This observational, prospective study was undertaken to estimate the burden of rotavirus (RV) gastroenteritis (GE) leading to general practitioner (GP)/family paediatrician (FP) visits among children aged <5 years in Czech Republic, Germany, Italy, Poland, Spain and the UK. Children aged <5...

  • Norovirus identification important as vaccination reduces rotavirus disease burden.  // Infectious Diseases in Children;Aug2009, Vol. 22 Issue 8, p36 

    The article discusses research on norovirus, which is considered the second most common agent that causes acute sporadic episodes of gastroenteritis in children younger than 5 years old, referencing a study by C. G. Junquera and colleagues published in a 2009 issue of the "Pediatric Infectious...

  • Clinical Manifestations and Treatment Outcomes of Eosinophilic Gastroenteritis in Children. Jong Sub Choi; Shin Jie Choi; Kyung Jae Lee; Ahlee Kim; Jung Kyung Yoo; Hye Ran Yang; Jin Soo Moon; Ju Young Chang; Jae Sung Ko; Gyeong Hoon Kang // Pediatric Gastroenterology, Hepatology & Nutrition;Dec2015, Vol. 18 Issue 4, p253 

    Purpose: The aim of the present study was to investigate the clinical features and outcome of eosinophilic gastroenteritis (EGE) in children. Methods: Our study enrolled 24 children who were diagnosed with EGE from 1993 to 2014 at the Department of Pediatrics, Seoul National University...

  • The Effects of Infant Feeding on Rotavirus-induced Gastroenteritis: A Prospective Study. Duffy, Linda C.; Byers, Tim E.; Marie Riepenhoff-Talty; Leonard J. La Scolea; Maria Zielezny; Ogra, Pearay L. // American Journal of Public Health;Mar86, Vol. 76 Issue 3, p259 

    Abstract: The relationship between feeding method and risk of rotavirus infection was studied by following a cohort of 197 infants from low income households through the winter diarrhea season of 1983-84. Fecal specimens were systematically collected and tested for the presence of rotavirus...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics