TITLE

Determination of chemical elements in biological fluids and diagnostic substrates from children by inductively coupled plasma mass spectrometry

AUTHOR(S)
Seregina, I.; Lanskaya, S.; Okina, O.; Bol’shov, M.; Lyapunov, S.; Chugunova, O.; Foktova, A.
PUB. DATE
September 2010
SOURCE
Journal of Analytical Chemistry;Sep2010, Vol. 65 Issue 9, p964
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Inductively coupled plasma mass spectrometry was used to analyze diagnostic substrates from newborns and primary school-aged children. We studied urine and blood samples of children aged from several days to 2 months and hair samples of primary school-aged children. Methods for the collection of blood and urine sample were investigated using various medical instruments and different procedures for sample preparation. We studied the effect of sample macrocomponents on the signals from analytes. It was found that sulfur had the largest effect on the intensity of the analytical signal. Methods for assessing matrix effects were considered, that is, the internal standard method and the addition of a matrix component to calibration solutions. The accuracy of the results was confirmed by analyzing certified reference materials and using the standard addition method.
ACCESSION #
53361509

 

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