TITLE

Merkel Cell Carcinoma: Important Aspects of Diagnosis and Management

AUTHOR(S)
Linjawi, Ayman; Jamison, W. Bruce; Meterissian, Sarkis
PUB. DATE
October 2001
SOURCE
American Surgeon;Oct2001, Vol. 67 Issue 10, p943
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Merkel cell carcinoma (MCC) is a highly aggressive primary neuroendocrine tumor. It is suggested in the literature that postoperative radiotherapy may decrease local recurrence and improve overall survival. The purpose of this retrospective review was to determine our experience and review the literature on this aggressive malignancy. Charts of ten patients with MCC seen between 1985 and 1997 were reviewed to obtain clinicopathological data. Eight patients were male with a mean age of 72 years (range 49-90). The head and neck was the most common site, affecting 50 per cent of patients. All patients had primary excisions with documented negative margins. Pathological size ranged from 10 to 40 mm. Initial pathological diagnosis was lymphoma in three cases requiring immunohistochemistry for cytokeratin and neuron-specific enolase for definitive diagnosis. Lymphatic invasion was noted in three patients but only one of these patients had clinical lymph node involvement. The mean follow-up was 54 months (range 6-114) with an 80 per cent one-year survival and 30 per cent 2-year survival. Postoperative radiotherapy was administered to five patients. Of these three died with evidence of both local and distant recurrence. This small retrospective review highlights important points in the management of MCC including pathological diagnosis and benefits of adjuvant radiation therapy.
ACCESSION #
5331203

 

Related Articles

  • Adjuvant prophylactic regional radiotherapy versus observation in stage I Merkel cell carcinoma: a multicentric prospective randomized study. Jouary, T.; Leyral, C.; Dreno, B.; Doussau, A.; Sassolas, B.; Beylot-Barry, M.; Renaud-Vilmer, C.; Guillot, B.; Bernard, P.; Lok, C.; Bedane, C.; Cambazard, F.; Misery, L.; Estève, E.; Dalac, S.; Machet, L.; Grange, F.; Young, P.; Granel-Brocard, F.; Truchetet, F. // Annals of Oncology;Apr2012, Vol. 23 Issue 4, p1074 

    Background: The treatment of stage I Merkel cell carcinoma (MCC) usually includes wide local excision (WLE) combined with irradiation of the tumor bed (ITB). No randomized study has ever been conducted in MCC. The purpose of this study was to assess the efficacy and safety of prophylactic...

  • Radiotherapy for Metastatic Merkel Cell Carcinoma: A Review of the Literature. Khan, Luluel; Barnes, Elizabeth A. // Journal of Skin Cancer;2012, p1 

    Introduction. Merkel cell carcinoma is a rare form of non-melanoma skin cancer of neuroendocrine origin. Optimal management of patients is controversial and the role of radiotherapy is unclear. Purpose. The purpose of this study was to review the efficacy of RT in the treatment of both local and...

  • Scarce data impedes MCC treatment. Sheldon, Nina // Dermatology Times;May2005, Vol. 26 Issue 5, p72 

    The article focuses on the scarce data available for the disease Merkel cell carcinoma (MCC) and discusses the available treatment for the disease. It states that because the disease is rare there has been very little data available for experts to come up with clinical decisions. It further...

  • Bcl-2 Antisense Oligonucleotides (G3139) Inhibit Merkel Cell Carcinoma Growth in SCID Mice. Schlagbauer-Wadl, Hermine; Klosner, Gabriele; Heere-Ress, Elisabeth; Waltering, Stefan; Moll, Ingrid; Wolff, Klaus; Pehamberger, Hubert; Jansen, Burkhard // Journal of Investigative Dermatology;Apr2000, Vol. 114 Issue 4, p725 

    Summary Merkel cell carcinoma was first described in 1972 by Toker and is an aggressive neuroendocrine skin tumor with a high metastatic potential. Merkel cell carcinoma is thought to derive from the neuroendocrine (Merkel) cells of the skin, although in contrast to fetal and especially adult...

  • Response to Shuda et al. Angermeyer, Sabrina; Hesbacher, Sonja; Becker, Jürgen C; Schrama, David; Houben, Roland // Journal of Investigative Dermatology;May2014, Vol. 134 Issue 5, p1481 

    A reply to a letter to the editor is presented in response to an article on Merkel cell polyoma virus (MCV).

  • Characterization of a Merkel Cell Polyomavirus-Positive Merkel Cell Carcinoma Cell Line CVG-1. Velásquez, Celestino; Amako, Yutaka; Harold, Alexis; Toptan, Tuna; Chang, Yuan; Shuda, Masahiro // Frontiers in Microbiology;4/11/2018, p1 

    Merkel cell polyomavirus (MCV) plays a causal role in 80% of Merkel cell carcinomas (MCC). MCV is clonally integrated into the MCC tumor genome, which results in persistent expression of large T (LT) and small T (sT) antigen oncoproteins encoded by the early locus. In MCV-positive MCC tumors, LT...

  • Merkel-cell Carcinoma in Behçet's Disease. Satolli, Francesca; Venturi, Caterina; Vescovi, Veronica; Morrone, Pietro; De Panfilis, Giuseppe // Acta Dermato-Venereologica;Jan2005, Vol. 85 Issue 1, p79 

    Presents a letter to the editor regarding the case of a patient with Behcet's disease who subsequently developed a Merkel cell carcinoma.

  • Deep excision necessary for merkel cell carcinoma. Helwick, Caroline // Dermatology Times;Sep2002, Vol. 23 Issue 9, p50 

    Discusses the importance of deep excision for merkel cell carcinoma in the U.S. Rarity of the condition; Awareness of the disease by physicians; Details on the clinical presentation of the cancer.

  • Merkel Cell Polyomavirus Is More Frequently Present in North American than Australian Merkel Cell Carcinoma Tumors. Garneski, Kelly M; Warcola, Ashley H; Feng, Qinghua; Kiviat, Nancy B; Leonard, J Helen; Nghiem, Paul // Journal of Investigative Dermatology;Jan2009, Vol. 129 Issue 1, p246 

    A letter to the editor is presented concerning the Merkel cell polyomavirus (MCPyV) in North American and Australian Merkel cell carcinoma tumors.

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics