TITLE

High prevalence of CTX-M β-lactamase-producing Enterobacteriaceae in stool specimens obtained from healthy individuals in Thailand

AUTHOR(S)
Sasaki, Tadahiro; Hirai, Itaru; Niki, Marie; Nakamura, Tatsuya; Komalamisra, Chalit; Maipanich, Wanna; Kusolsuk, Teera; Sa-nguankiat, Surapol; Pubampen, Somchit; Yamamoto, Yoshimasa
PUB. DATE
April 2010
SOURCE
Journal of Antimicrobial Chemotherapy (JAC);Apr2010, Vol. 65 Issue 4, p666
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Objectives: To determine the prevalence of CTX-M β-lactamase-producing Enterobacteriaceae in stool specimens obtained from healthy individuals in a rural area of Thailand. Methods: Bacteria in stool specimens were screened for extended-spectrum β-lactamase (ESBL) production on McConkey agar with cefotaxime and confirmed by the double-disc synergy test. Genetic detection and genotyping of CTX-M-type ESBL was performed by PCR with bacterial DNA extracted from isolates. Results: A markedly high number (82 of 141, 58.2%) of the specimens showed the presence of CTX-M β-lactamase-producing Enterobacteriaceae, as confirmed by both phenotypic and genetic examinations. The majority of the CTX-M b-lactamase-producing bacteria were Escherichia coli (85.1%). Conclusions: The study revealed the wide dissemination of CTX-M β-lactamase-producing Enterobacteriaceae in the healthy population.
ACCESSION #
53297943

 

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