Mouse Connexin 45: Genomic Cloning and Exon Usage
- Cloning, Characterization, and Genomic Structure of the Mouse Ikbkap Gene. Cuajungco, Math P.; Leyne, Maire; Mull, James; Gill, Sandra P.; Gusella, James F.; Slaugenhaupt, Susan A. // DNA & Cell Biology;Sep2001, Vol. 20 Issue 9, p579
Our laboratory recently reported that mutations in the human I-?B kinase-associated protein (IKBKAP) gene are responsible for familial dysautonomia (FD). Interestingly, amino acid substitutions in the IKAP correlate with increased risk for childhood bronchial asthma. Here, we report the cloning...
- Dolly, you're history. Lemonick, Michael D.; Gibson, Helen; Park, Alice // Time International (South Pacific Edition);8/3/1998, Issue 31, p52
Reports on how scientists are taking cloning one step further in 1998. How Teruhiko Wakayama successfully cloned mice; The number of cloned mice created in the laboratory through the use of a system called Cumulina; Details of the mice; Possible applications of such findings.
- Functional annotation of a full-length mouse cDNA collection. Kawai, J.; Shinagawa, A.; Shibata, K.; Yoshino, M.; Itoh, M.; Ishii, Y.; Arakawa, T.; Hara, A.; Fukunishi, Y.; Konno, H.; Adachi, J.; Fukuda, S.; Aizawa, K.; Izawa, M.; Nishi, K.; Kiyosawa, H.; Kondo, S.; Yamanaka, I.; Saito, T.; Okazaki, Y. // Nature;2/8/2001, Vol. 409 Issue 6821, p685
Presents a study from Japan's RIKEN Mouse Gene Encyclopaedia Project, which is working systematically to determine the full coding potential of the mouse genome. Description of the first RIKEN clone collection; Annotation and analysis of these cDNAs; Strategies; cDNAs which represent metabolic...
- Cumulina and her sisters. Caldwell, Mark // Discover;Jan1999, Vol. 20 Issue 1, p56
Reports on the successful cloning of a mouse in 1998. Difference of the cloned mouse from previous cloning efforts; Overview of the cloning technique.
- Dolly has company. G.S.; Stover, Dawn // Popular Science;Nov98, Vol. 253 Issue 5, p32
Reports on the successful cloning of a mice from adult cells. Technique used in cloning; Use of the mice as a model for cloning.
- Copying a multitude of mice. Sobel, Rachel K. // U.S. News & World Report;08/03/98, Vol. 125 Issue 5, p52
Reports that researchers cloned three generations of healthy mice. Research by Ryuzo Yanagimachi, University of Hawaii; Use of a new technique; Confirmation that Dolly the sheep was cloned; Feasibility of human cloning.
- Human clones a step closer. Borntrager, Dan; Fillon, Mike; Shuldiner, Herb; Weissler, Paul; Wilson, Ashley // Popular Mechanics;Oct98, Vol. 175 Issue 10, p20
Focuses on the successful cloning of an adult mouse by scientists at the University of Hawaii. Cells used in cloning; Difference of the cloning technique used in the sheep Dolly; Implications of the cloning results.
- A New Transgenic Mouse Model of Dominant Connexin 26 Mutation Indicates That Differential Intracellular Processing of Mutant Connexins Produces Distinct Phenotypes in Vivo. // Journal of Medical Genetics;Sep2004 Supplement, Vol. 41, pS63
Presents an abstract of the study entitled "A New Transgenic Mouse Model of Dominant Connexin 26 Mutation Indicates That Differential Intracellular Processing of Mutant Connexins Produces Distinct Phenotypes in Vivo," by Geoege Bakirtzis, T. Aasen, S. Bryson, S. Forrow, L. Tetley, M. E. Finbow,...
- miR-125b Inhibits Connexin43 and Promotes Glioma Growth. Jin, Zheng; Xu, Songbai; Yu, Hongquan; Yang, Boyu; Zhao, Hongguang; Zhao, Gang // Cellular & Molecular Neurobiology;Nov2013, Vol. 33 Issue 8, p1143
MicroRNA is strongly associated with tumor growth and development. This study examined the potential roles of miR-125b in glioma growth. We found that miR-125b promotes glioma cell line growth and clone formation, and protects the glioma cells from apoptosis in vitro. The miR-125b-transfected...