CLINICAL REPORTS. Pattern of clopidogrel use in hospitalized patients receiving percutaneous coronary interventions

Dean, Bonnie B.; Yu, Hsing-Ting; Bae, Jay P.; Fiske, Suzanne; Meadows, Eric; Xiong, Yan; Emons, Matthew F.
September 2010
American Journal of Health-System Pharmacy;9/1/2010, Vol. 67 Issue 17, p1430
Academic Journal
Purpose. The pattern of clopidogrel loading in patients who had undergone percutaneous coronary intervention (PCI) was studied in a retrospective analysis of clinical records. Methods. A database of deidentified electronic medical records from hospitals and hospital-affiliated outpatient facilities throughout the United States was analyzed for PCI patients with or without a diagnosis of acute coronary syndrome (ACS) who received clopidogrel loading doses of ≥300 mg between 48 hours before and 6 hours after PCI. A high dose was defined as ≥600 mg, and pretreatment was defined as more than 6 hours before PCI for 300--599 mg and 2 or more hours before PCI for ≥600 mg. Results. Among 6253 PCI patients who met the criteria, there were 2331 with a diagnosis of ACS (ACS-PCI) and 3922 without an ACS diagnosis (elective PCI). Of the ACS-PCI patients, 1359 had ST-segment elevation myocardial infarction (STEMI) and 972 had unstable angina (UA) or non-ST-segment elevation myocardial infarction (NSTEMI). A majority of ACS-PCI patients (57%) received a ≥600-mg loading dose, 34% received a 300-mg loading dose, and the rest received a loading dose between 300 and 600 mg. Loading consisted of a single bolus in 75% of patients, two doses in 21.5%, and three or more doses in 3.1%. The first dose was during or after PCI in 56% of the UA/NSTEMI group and in 71% of both the elective PCI and STEMI groups. Among the UA/NSTEMI group, only 33% met criteria for pretreatment. Conclusion. Reported practice patterns of clopidogrel administration before PCI for UA/NSTEMI were not consistent with evidence generated from published clinical trials and guidelines. Recommended pretreatment with clopidogrel was frequently not practiced.


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