TITLE

Modeling the sustained release of lipophilic drugs from liposomes

AUTHOR(S)
Like Zeng; Xiaoyi Wu
PUB. DATE
August 2010
SOURCE
Applied Physics Letters;8/16/2010, Vol. 97 Issue 7, p073701
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The bilayered structure of liposomes enables the encapsulation of lipophilic drugs in their lipid bilayers and water-soluble molecules in the interior aqueous compartments. We develop a convection-driven drug release model that considers the structural characteristics of liposomes and reversible drug-lipid interaction. An analytical solution to the model is obtained. The solution agrees well with experimental data on the sustained release of lipophilic anticancer drugs from liposomes. The model provides a useful tool for the rational design of liposomal drug delivery systems.
ACCESSION #
52997951

 

Related Articles

  • DESIGN AND CHARACTERIZATION OF LONG CIRCULATING LYOPHILIZED VESICULAR DRUG DELIVERY SYSTEM FOR ANTINEOPLASTIC AGENTS. GOJE, ARJUN; DOIJAD, RAJENDRA C.; SOMPUR, C. K. // International Journal of Pharma & Bio Sciences;Jul-Sep2011, Vol. 2 Issue 3, pP.238 

    Gemcitabine is an antineoplastic agent commonly used to treat some types of leukemia as well as cancers. In the present study, long circulating liposomal drug delivery system for Gemcitabine was developed, which will increase the efficacy and reduce the toxicity and target the organs (RES). Long...

  • PCL/PEG Copolymeric Nanoparticles: Potential Nanoplatforms for Anticancer Agent Delivery. MaLing Gou; XiaWei Wei; Ke Men; BiLan Wang; Feng Luo; Xia Zhao; YuQuan Wei; ZhiYong Qian // Current Drug Targets;Jul2011, Vol. 12 Issue 8, p1131 

    No abstract available.

  • A REVIEW ON POLYMERIC MICELLAR NANOCARRIERS. DHEMBRE, G. N.; MOON, R. S.; KSHIRSAGAR, R. V. // International Journal of Pharma & Bio Sciences;Apr-Jun2011, Vol. 2 Issue 2, pP.109 

    Micelles, self-assembling nanosized (5-100 nm) colloidal particles with a hydrophobic core and hydrophilic shell are currently successfully used as pharmaceutical carriers for waterinsoluble drugs and demonstrate a series of attractive properties as drug carriers. These polymeric miscellar...

  • Caleosin-based nanoscale oil bodies for targeted delivery of hydrophobic anticancer drugs. Chiang, Chung-Jen; Lin, Li-Jen; Chen, Chih-Jung // Journal of Nanoparticle Research;Dec2011, Vol. 13 Issue 12, p7127 

    Nanoscale artificial oil bodies (NOBs) could be assembled from plant oil, phospholipids (PLs), and oleosin (Ole) as previously reported. NOBs have a lipid-based structure that contains a central oil space enclosed by a monolayer of Ole-bound PLs. As an oil structural protein, Ole functions to...

  • Preparation of PEG functionalized nanoparticles for drug delivery to cancer cells. Yan Liu; Jie Ren; Junzhao Leng; Jianbo Li; Li Deng // Advanced Materials Research;2014, Issue 893, p194 

    Nanosized calcium phosphate was prepared by a reverse microemulsion method, with a 20~40 nm diameter, which is pH-responsive, nontoxic and colloidally stable in physiological solution. Polyethylene glycol modified calcium phosphate nanoparticles shifted the zeta potential to a neutral charge,...

  • DEVELOPMENT OF INNOVATIVE NANOTECHNOLOGY-BASED DRUG DELIVERY SYSTEMS FOR CANCER THERAPY. Moutinho, Carla; Matos, Carla; Balcão, Victor // Revista da Faculdade de Ciências da Saúde;2007, Issue 4, p94 

    Controlled drug delivery systems are not a new subject in the biomedical field. The continuously increasing need for the improvement of health care services has been the driving force for both search and development of such systems. Among these, micro- and nano-sized vehicles (e.g. nanocapsules,...

  • Formulation and Evaluation of Celastrol-Loaded Liposomes. Jie Song; Feng Shi; Zhenhai Zhang; Fenxia Zhu; Jing Xue; Xiaobin Tan; Luyong Zhang; Xiaobin Jia // Molecules;Sep2011, Vol. 16 Issue 9, p7880 

    The main purpose of this study was to evaluate the intestinal absorption and the antineoplastic effect of the poorly water-soluble drug celastrol when liposomes were used as oral drug delivery system. Liposomes were prepared by the ethanol-injection method. An optimized liposome formulation...

  • Vincristine Liposomal - INEX: Lipid-Encapsulated Vincristine, Onco TCS, Transmembrane Carrier System – Vincristine, Vincacine, Vincristine Sulfate Liposomes for Injection, VSLI. Adis International Limited // Drugs in R&D;2004, Vol. 5 Issue 2, p119 

    INEX Pharmaceuticals is developing a liposomal formulation of vincristine [Onco TCS, vincacine, VSLL Vincris tine sulfate liposomes for injection] for the treatment of relapsed aggressive non-Hodgkin's lymphoma (NHL) and other cancers. It is being developed using INEX' s proprietary...

  • Panacea. Crow, James Mitchell // New Scientist;4/27/2013, Vol. 218 Issue 2914, p40 

    The article discusses research into the development of smart drugs able to deliver active ingredients to the specific disease target within the body without any side effects on healthy tissues. Particular focus is given to the anticancer drug Doxil, which used polyethylene glycol (PEG) coated...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics