TITLE

The Decline of Pneumococcal Resistance after Cessation of Mass Antibiotic Distributions for Trachoma

AUTHOR(S)
Haug, Sara; Lakew, Takele; Habtemariam, Gabremaskal; Alemayehu, Wondu; Cevallos, Vicky; Zhaoxia Zhou; House, Jenafir; Ray, Kathryn; Porco, Travis; Rutar, Tina; Keenan, Jeremy; Lietman, Thomas M.; Gaynor, Bruce D.
PUB. DATE
September 2010
SOURCE
Clinical Infectious Diseases;9/1/2010, Vol. 51 Issue 5, p571
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
After 6 biannual mass distributions of oral azithromycin for trachoma in Ethiopian communities, 76.8% (95% confidence interval [CI], 66.3%-85.1%) of nasopharyngeal Streptococcus pneumoniae isolates from children aged 1-5 years were resistant to macrolides. Twelve and 24 months after the last azithromycin treatment, resistance decreased to 30.6% (95% CI, 18.8%-40.4%; P < .001) and 20.8% (95% CI, 12.7%-30.7%; P < .001), respectively. Macrolide resistance decreases after antibiotic pressure is removed.
ACCESSION #
52937994

 

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