TITLE

The genetics of African trypanosomes

AUTHOR(S)
TAIT, A.
PUB. DATE
March 2009
SOURCE
Onderstepoort Journal of Veterinary Research;Mar2009, Vol. 76 Issue 1, p33
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The article examines the sexual cycle of Trypanosoma brucei in Africa. It illustrates how genetic analysis can be used as a tool to identify genes of relevance to the disease, as well as its transmission and treatment. It also determines the role of the process in the generation of diversity in the field by considering populations of the three sub-species of Trypanosoma brucei and the availability of genome sequence data.
ACCESSION #
52874052

 

Related Articles

  • Whole Genome Sequence Analysis of Cryptococcus gattii from the Pacific Northwest Reveals Unexpected Diversity. Gillece, John D.; Schupp, James M.; Balajee, S. Arunmozhi; Harris, Julie; Pearson, Talima; Yan, Yongpan; Keim, Paul; DeBess, Emilio; Marsden-Haug, Nicola; Wohrle, Ron; Engelthaler, David M.; Lockhart, Shawn R. // PLoS ONE;2011, Vol. 6 Issue 12, p1 

    A recent emergence of Cryptococcus gattii in the Pacific Northwest involves strains that fall into three primarily clonal molecular subtypes: VGIIa, VGIIb and VGIIc. Multilocus sequence typing (MLST) and variable number tandem repeat analysis appear to identify little diversity within these...

  • Genomics: Three deadly trypanosomatids decoded. Skipper, Magdalena // Nature Reviews Genetics;Sep2005, Vol. 6 Issue 9, p665 

    Discusses researches which investigated the characteristics of the genomes of Trypanosoma cruzi, Leishmania major and Trypanosoma brucei. Information on the haploid genomes of the parasites; Ability of the parasites to encode proteins with RNA-binding motifs; Importance of the research to...

  • TrypanoCyc -- a metabolic pathway database for Trypanosoma brucei. Chukualim, Bridget; Peters, Nick; Fowler, Christiane Hertz; Berriman, Matthew // BMC Bioinformatics;2008 Supplement 10, Vol. 9, Special section p1 

    Background Trypanosoma brucei (T. brucei) is a single celled parasite, subspecies of which are causative agents of African sleeping sickness in humans and nagana in domestic animals. Sleeping sickness is endemic in about 36 countries in Sub- Saharan Africa and is threatening over 60 million...

  • The Molecular Control of Antigenic Variation in Trypanosoma brucei. Horn, David // Current Molecular Medicine;Sep2004, Vol. 4 Issue 6, p563 

    The African trypanosome, Trypanosoma brucei, is a protozoan that causes sleeping sickness in humans and N'gana in livestock. These flagellated parasites are directly exposed to immune defences as they circulate in the mammalian host bloodstream but they maintain persistent infections by...

  • Tandem gene arrays in Trypanosoma brucei: Comparative phylogenomic analysis of duplicate sequence variation. Jackson, Andrew P. // BMC Evolutionary Biology;2007, Vol. 7, p1 

    Background: The genome sequence of the protistan parasite Trypanosoma brucei contains many tandem gene arrays. Gene duplicates are created through tandem duplication and are expressed through polycistronic transcription, suggesting that the primary purpose of long, tandem arrays is to increase...

  • A Genome-Wide Analysis of Genetic Diversity in Trypanosoma cruzi Intergenic Regions. Panunzi, Leonardo G.; Agüero, Fernán // PLoS Neglected Tropical Diseases;May2014, Vol. 8 Issue 5, p1 

    Background: Trypanosoma cruzi is the causal agent of Chagas Disease. Recently, the genomes of representative strains from two major evolutionary lineages were sequenced, allowing the construction of a detailed genetic diversity map for this important parasite. However this map is focused on...

  • The exopolyphosphatase TbrPPX1 of Trypanosoma brucei. Luginbuehl, Edith; Kunz, Stefan; Wentzinger, Laurent; Freimoser, Florian; Seebeck, Thomas // BMC Microbiology;2011, Vol. 11 Issue 1, p1 

    Background: Exopolyphosphatases and pyrophosphatases play important but still incompletely understood roles in energy metabolism, and also in other aspects of cell biology such as osmoregulation or signal transduction. Earlier work has suggested that a human exopolyphosphatase, Prune, might...

  • Variant Surface Glycoprotein gene repertoires in Trypanosoma brucei have diverged to become strain-specific. Hutchinson, O Clyde; Picozzi, Kim; Jones, Nicola G; Mott, Helen; Sharma, Reuben; Welburn, Susan C; Carrington, Mark // BMC Genomics;2007, Vol. 8, p1 

    Background: In a mammalian host, the cell surface of African trypanosomes is protected by a monolayer of a single variant surface glycoprotein (VSG). The VSG is central to antigenic variation; one VSG gene is expressed at any one time and there is a low frequency stochastic switch to expression...

  • A Minimal Anaphase Promoting Complex/Cyclosome (APC/C) in Trypanosoma brucei. Bessat, Mohamed; Knudsen, Giselle; Burlingame, Alma L.; Wang, Ching C. // PLoS ONE;Mar2013, Vol. 8 Issue 3, p1 

    The anaphase-promoting complex/cyclosome (APC/C) is a multi-subunit E3 ubiquitin ligase that initiates chromosome segregation and mitotic exit by targeting critical cell-cycle regulators for proteolytic destruction. Previously, seven APC/C subunit homologues were identified in the genome of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics