TITLE

Type 2 diabetes mellitus is associated with impaired cytokine response and adhesion molecule expression in human endotoxemia

AUTHOR(S)
Andreasen, Anne; Pedersen-Skovsgaard, Theis; Berg, Ronan M. G.; Svendsen, Kira Dynnes; Feldt-Rasmussen, Bo; Pedersen, Bente K.; Møller, Kirsten
PUB. DATE
September 2010
SOURCE
Intensive Care Medicine;Sep2010, Vol. 36 Issue 9, p1548
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Type 2 diabetes is associated with an increased risk of acquiring infectious diseases and developing sepsis. This may partly be due to immune dysfunction. We investigated the in vivo innate immune response of type 2 diabetic persons to an intravenous injection of E. coli lipopolysaccharide (LPS). After ethics approval, informed consent and a thorough physical examination, 19 type 2 diabetic patients and 23 healthy controls were included. LPS was given as an intravenous bolus injection of 0.3 ng/kg. Physiological variables, white blood cell count, and plasma concentrations of tumour necrosis factor (TNF), interleukin-6 (IL-6), interleukin-1 receptor antagonist (IL-1ra), and the adhesion molecules E-selectin, vascular adhesion molecule (VCAM)-1, and intracellular adhesion molecule (ICAM)-1 were measured hourly for 8 h. LPS injection induced a systemic inflammatory response with increases in neutrophils, temperature, heart rate and plasma concentrations of cytokines and adhesion molecules in healthy and type 2 diabetic volunteers. Type 2 diabetes was associated with less pronounced LPS-induced increases in TNF, IL-1ra, VCAM-1 and ICAM-1. There was a trend towards an attenuated upregulation of E-selectin in diabetics, even though the plasma concentration tended to be generally higher compared to healthy controls. Patients with type 2 diabetes exhibit an attenuated increase in plasma levels of TNF and IL-1ra, as well as an attenuated upregulation of VCAM-1 and ICAM-1 to LPS in vivo. This finding may provide a mechanistic explanation for the adverse outcome seen during infectious diseases in diabetic patients.
ACCESSION #
52858870

 

Related Articles

  • Involvement of sulfatide in beta cells and type 1 and type 2 diabetes. Buschard, K.; Blomqvist, M.; Osterbye, T.; Fredman, P. // Diabetologia;Oct2005, Vol. 48 Issue 10, p1957 

    Mammalian tissues express β-isoforms of glycosphingolipids and, among these, sulfatide (sulphated galactosylceramide) is present in the beta cells, and it is here that the short fatty acid chain (C16) isoform is predominately found. In vitro studies have shown that sulfatide preserves insulin...

  • Tuberculosis in Poorly Controlled Type 2 Diabetes: Altered Cytokine Expression in Peripheral White Blood Cells. Restrepo, Blanca I.; Fisher-Hoch, Susan P.; Pino, Paula A.; Salinas, Adrian; Rahbar, Mohammad H.; Mora, Francisco; Cortes-Penfield, Nicolas; McCormick, Joseph B. // Clinical Infectious Diseases;9/1/2008, Vol. 47 Issue 5, p634 

    Background. Although the biological basis for the increased susceptibility of diabetic patients to tuberculosis remains unclear, the world is undergoing a type 2 diabetes pandemic. We hypothesize that chronic hyperglycemia leads to immunocompromise that facilitates progression to active...

  • Interleukin-10 Prevents Diet-Induced Insulin Resistance by Attenuating Macrophage and Cytokine Response in Skeletal Muscle. Eun-Gyoung Hong; Hwi Jin Ko; You-Ree Cho; Hyo-Jeong Kim; Zhexi Ma; Yu, Tim Y.; Friedline, Randall H.; Kurt-Jones, Evelyn; Finberg, Robert; Fischer, Matthew A.; Granger, Erica L.; Norbury, Christopher C.; Hauschka, Stephen D.; Philbrick, William M.; Chun-Geun Lee; Elias, Jack A.; Kim, Jason K. // Diabetes;Nov2009, Vol. 58 Issue 11, p2525 

    OBJECTIVE--Insulin resistance is a major characteristic of type 2 diabetes and is causally associated with obesity. Inflammation plays an important role in obesity-associated insulin resistance, but the underlying mechanism remains unclear. Interleukin (IL)-10 is an anti-inflammatory cytokine...

  • Interleukin (IL)-10 Gene Polymorphisms Are Associated with Type 2 Diabetes With and Without Nephropathy: A Study of Patients from the Southeast Region of Iran. Kazemi Arababadi, Mohammad; Reza Mirzaei, Mohammad; Ali Sajadi, Seyed; Hassanshahi, Gholamhossein; Ahmadabadi, Behzad; Salehabadi, Vajihe; Derakhshan, Reza; Kennedy, Derek // Inflammation;Jun2012, Vol. 35 Issue 3, p797 

    The impact of several environmental and genetic factors on diabetes and its complications is well documented. It has also been established that cytokines play a key role in the regulation of immune responses which have been shown to be important in the pathogenesis of diabetes. Studies showed...

  • Role of Mindin in Diabetic Nephropathy. Murakoshi, Maki; Gohda, Tomohito; Tanimoto, Mitsuo; Funabiki, Kazuhiko; Horikoshi, Satoshi; Tomino, Yasuhiko // Experimental Diabetes Research;2011, Special section p1 

    A number of studies have shown that proinflammatory cytokines have important roles in determining the development of microvascular diabetic complications, including nephropathy. Inflammatory biomarkers should be useful for diagnosis or monitoring of diabetic nephropathy. Mindin (spondin 2) is a...

  • Inhibition of TNF-α Improves the Bladder Dysfunction That Is Associated With Type 2 Diabetes. Zongwei Wang; Zhiyong Cheng; Cristofaro, Vivian; Jijun Li; Xingyuan Xiao; Gomez, Pablo; Ge, Rongbin; Gong, Edward; Strle, Klemen; Sullivan, Maryrose P.; Adam, Rosalyn M.; White, Morris F.; Olumi, Aria F. // Diabetes;Aug2012, Vol. 61 Issue 8, p2134 

    Diabetic bladder dysfunction (DBD) is common and affects 80% of diabetic patients. However, the molecular mechanisms underlying DBD remain elusive because of a lack of appropriate animal models. We demonstrate DBD in a mouse model that harbors hepatic-specific insulin receptor substrate 1 and 2...

  • Human Endotoxemia as a Model of Systemic Inflammation. Andreasen, A. S.; Krabbe, K. S.; Krogh-Madsen, R.; Taudorf, S.; Pedersen, B. K.; M�ller, K. // Current Medicinal Chemistry;2008, Vol. 15 Issue 17, p1697 

    Systemic inflammation is a pathogenetic component in a vast number of acute and chronic diseases such as sepsis, trauma, type 2 diabetes, atherosclerosis, and Alzheimer's disease, all of which are associated with a substantial morbidity and mortality. However, the molecular mechanisms and...

  • Chemokine antagonism in chronic hepatitis C virus infection. Charles, Edgar D.; Dustin, Lynn B. // Journal of Clinical Investigation;Jan2011, Vol. 121 Issue 1, p25 

    Immune responses to hepatitis C virus (HCV) fail to clear the virus in most individuals. Why patients who are less likely to clear HCV infection have high plasma levels of CXCL10 (also known as IP-10), a chemokine that directs T cells to sites of infection, has long been unclear. In this issue...

  • Is Reduced First-Phase Insulin Release the Earliest Detectable Abnormality in Individuals Destined to Develop Type 2 Diabetes? Gerich, John E. // Diabetes;Feb2002 Supplement, Vol. 51, pS117 

    Insulin is released from the pancreas in a biphasic manner in response to a square-wave increase in arterial glucose concentration. The first phase consists of a brief spike lasting ∼10 min followed by the second phase, which reaches a plateau at 2–3 h. It is widely thought that...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics