Effectiveness of hygienic-dietary recommendations as enhancers of antidepressant treatment in patients with Depression: Study protocol of a randomized controlled trial

Garcia-Toro, Mauro; Ibarra, Olga; Gili, Margalida; Salva, Joan; Monzón, Saray; Vives, Margalida; Serrano, Maria J; Garcia-Campayo, Javier; Roca, Miquel
January 2010
BMC Public Health;2010, Vol. 10 Issue 1, p404
Academic Journal
Background: In recent years some studies have been published supporting the efficacy of light exposure, physical activity, sleep control and a Mediterranean diet pattern on the improvement or prevention of Depression. However, to our knowledge, there have been no studies using all these measures together as an adjuvant antidepressant strategy. Methods: Multicenter, randomized, controlled, two arm-parallel, clinical trial. Eighty depressed patients undergoing standard antidepressant treatment will be advised to follow four additional hygienic-dietary recommendations about exercise, diet, sunlight exposure and sleep. Outcome measures will be assessed before and after the 6 month intervention period. Discussion: We expect the patients in the active recommendations group to experience a greater improvement in their depressive symptoms. If so, this would be a great support for doctors who might systematically recommend these simple and costless measures, especially in primary care. Trial Registration: ISRCTN59506583


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