Cumulative exposure to air pollution and long term outcomes after first acute myocardial infarction: A population-based cohort study. Objectives and methodology

Gerber, Yariv; Myers, Vicki; Broday, David M.; Koton, Silvia; Steinberg, David M.; Drory, Yaacov
January 2010
BMC Public Health;2010, Vol. 10 Issue 1, p369
Academic Journal
Background: Cardiovascular disease is a leading cause of morbidity and mortality worldwide and epidemiological studies have consistently shown an increased risk for cardiovascular events in relation to exposure to air pollution. The Israel Study of First Acute Myocardial Infarction was designed to longitudinally assess clinical outcomes, psychosocial adjustment and quality of life in patients hospitalized with myocardial infarction. The current study, by introducing retrospective air pollution data, will examine the association between exposure to air pollution and outcome in myocardial infarction survivors. This report will describe the methods implemented and measures employed. The study specifically aims to examine the relationship between residential exposure to air pollution and long-term risk of recurrent coronary event, heart failure, stroke, cardiac and all-cause death in a geographically defined cohort of patients with myocardial infarction. Methods/Design: All 1521 patients aged ⩽65 years, admitted with first myocardial infarction between February 1992 and February 1993 to the 8 hospitals serving the population of central Israel, were followed for a median of 13 years. Data were collected on sociodemographic, clinical and environmental factors. Data from air quality monitoring stations will be incorporated retrospectively. Daily measures of air pollution will be summarised, allowing detailed maps to be developed in order to reflect chronic exposure for each participant. Discussion: This study addresses some of the gaps in understanding of the prognostic importance of air pollution exposure after myocardial infarction, by allowing a sufficient follow-up period, using a well-defined community cohort, adequately controlling for multiple and multilevel confounding factors and providing extensive data on various outcomes.


Related Articles

  • Trends in long-term survival following acute myocardial infarction and revascularization. Linden, Belinda // British Journal of Cardiac Nursing;Apr2009, Vol. 4 Issue 4, p196 

    A summary of the article "Long Term Survival After Evidence Based Treatment of Acute Myocardial Infarction and Revascularisation: Follow Up of Population Based Perth MONICA Cohort," from the journal "British Medical Journal" is presented. The long-term survival of three cohorts of patients...

  • Air pollution and emergency admissions in Boston, MA. Zanobetti, Antonella; Schwartz, Joel // Journal of Epidemiology & Community Health;Oct2006, Vol. 60 Issue 10, p890 

    Study Objective: Many studies have shown that ambient particulate air pollution (PM) is associated with increased risk of hospital admissions and deaths for cardiovascular or respiratory causes around the world. In general these have been analysed in association with PM10 and ozone, whereas PM25...

  • The Effect of Particulate Air Pollution on Emergency Admissions for Myocardial Infarction: A Multicity Case-Crossover Analysis. Zanobetti, Antonella; Schwartz, Joel // Environmental Health Perspectives;Aug2005, Vol. 113 Issue 8, p978 

    Recently, attention has focused on whether particulate air pollution is a specific trigger of myocardial infarction (MI). The results of several studies of single locations assessing the effects of ambient particular matter on the risk of MI have been disparate. We used a multicity...

  • Out-of-Hospital Cardiac Arrests and Outdoor Air Pollution Exposure in Copenhagen, Denmark. Wichmann, Janine; Folke, Fredrik; Torp-Pedersen, Christian; Lippert, Freddy; Ketzel, Matthias; Ellermann, Thomas; Loft, Steffen; Cate, Hugo ten // PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1 

    Cardiovascular disease is the number one cause of death globally and air pollution can be a contributing cause. Acute myocardial infarction and cardiac arrest are frequent manifestations of coronary heart disease. The objectives of the study were to investigate the association between 4 657...

  • Less clarity as the fog begins to lift. Shah, Anoop S. V.; Newby, David E. // Heart;Jul2014, Vol. 100 Issue 14, p1073 

    The author discusses the adverse health effects of air pollution on cardiovascular disease. He discusses the use of database Myocardial Ischaemia National Audit Project to identify patients admitted for myocardial infarction. He also mentions the role of coronary heart disease, cerebrovascular...

  • Renal physiology and kidney stones.  // Nephrology Dialysis Transplantation;May2013 Supplement, Vol. 28 Issue suppl_1, pi54 

    No abstract available.

  • Elevated Plasma Homocysteine Level Is an Independent Predictor of Coronary Heart Disease Events in Patients with Type 2 Diabetes Mellitus. Minna Soinio, Daniel; Rönnemaa, Tapani; Marniemi, Jukka; Markku Laakso; Seppo Lehto, Jukka // Annals of Internal Medicine;1/20/2004, Vol. 140 Issue 2, p94 

    Background: High plasma homocysteine level has been associated with increased risk for coronary heart disease (CHD) events in nondiabetic individuals, especially in those with previously diagnosed CHD. In persons with type 2 diabetes mellitus, the association between homocysteine level and...

  • Recalibration of the Framingham functions to the Chinese population improved coronary heart disease risk estimates.  // ACP Journal Club;Nov/Dec2004, Vol. 141 Issue 3, p81 

    The article addresses the question how the recalibration of the Framingham functions compares with the performance of the functions derived from the Chinese Multi-provincial Cohort Study [CMCS] for determining the absolute risk for coronary heart disease (CHD) in patients without CHD. The...

  • COMMENTARY: Recalibration of the Framingham functions to the Chinese population improved coronary heart disease risk estimates. Fodor, J. George // ACP Journal Club;Nov/Dec2004, Vol. 141 Issue 3, p81 

    The article presents a commentary on the study, which concluded that recalibration of the Framingham functions to the Chinese population improved coronary heart disease (CHD) risk estimates. The Framingham risk function is the gold standard of global CHD risk evaluation. During the past decade,...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics