TITLE

BDNF Val66Met polymorphism, energy intake and BMI: a follow-up study in schoolchildren at risk of eating disorders

AUTHOR(S)
Arija, Victoria; Ferrer-Barcala, Marta; Aranda, Nuria; Canals, Josepa
PUB. DATE
January 2010
SOURCE
BMC Public Health;2010, Vol. 10 Issue 1, p363
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Eating disorders (ED) have a multifactorial aetiology in which genetics play an important role. Several studies have found an association between the Val66Met (G196A) polymorphism of the Brain-Derived Neurotrophic Factor (BDNF) and Eating disorders. The aim of this study was to determine the association of the Val66Met (G196A) polymorphism of the BDNF gene and its effect on eating disorders (ED), energy intake and BMI in schoolchildren. Methods: Two-year cohort study (preadolescence to adolescence). From an initial sample of 1336 Caucasian children (mean age = 11.37 years), a group at risk of ED (n = 141) and a control group (n = 117) were selected using the Children's Eating Attitudes Test. Two years later, they were re-classified into an at-risk group (n = 41) and a control group (n = 159) using the Eating Attitudes Test. The diagnosis of the individuals at risk of ED was confirmed by means of the Diagnostic Interview for Children and Adolescents. BMI, energy intake and the Val66Met (G196A) polymorphism of the BDNF gene were analysed in the at-risk and control groups. Results: The frequency of genotypes of the Val66Met (G196A) polymorphism of the BDNF gene is 28.6% (95% CI: 22.4-34.9) in the heterozygous form (Val/Met) and 5% (95% CI: 2.4-9) in the homozygous form (Met/Met). We detected no association between Val66Met genotypes and the severity of ED. Over time, the carriers of the Met66 allele with a persistent risk of ED significantly restricted energy intake (507 Kcal/day; p = 0.033). Conclusion: We have not found an association between Val66Met (G196A) polymorphism of the BDNF and ED in schoolchildren from general population. The relationship found between this polymorphism and energy intake restriction in adolescents with a persistent risk of ED should be replicated in a larger sample.
ACCESSION #
52840022

 

Related Articles

  • Body Image and Body Change: Predictive Factors in an Iranian Population. Garrusi, Behshid; Garousi, Saeide; Baneshi, Mohammad R. // International Journal of Preventive Medicine;Aug2013, Vol. 4 Issue 8, p940 

    Background: Body concerns and its health consequences such as eating disorders and harmful body change activities are mentioned in Asian countries. This study evaluates factors contributing to body image/shape changes in an Iranian population. Methods: In this cross sectional study we focused on...

  • Orthorexia Nervosa and Adaptation of ORTO-11 into Turkish. Arusoğlu, Gülğan; Kabakçi, Elif; Köksal, Gülden; Merdol, Türkan Kutluay // Turkish Journal of Psychiatry;2008, Vol. 19 Issue 3, p1 

    Objective: Orthorexia pathological fixation about the consumption of healthy food.The present study aimed to reveal the psychometric properties of the Turkish version of ORTO-15, which was developed to evaluate orthorexia, and to investigate the relationship between orthorexia, and eating...

  • Preadolescent Disordered Eating Predicts Subsequent Eating Dysfunction. Combs, Jessica L.; Pearson, Carolyn M.; Zapolski, Tamika C. B.; Smith, Gregory T. // Journal of Pediatric Psychology;Jan/Feb2013, Vol. 38 Issue 1, p41 

    Objective This article tested whether disordered eating in the spring of sixth grade can be predicted by the behaviors of fifth grade elementary school children. Method Measurements of disordered eating were collected from 1906 children (mean age = 10.86 years) at Time 1 (spring of fifth grade),...

  • Psychological and anthropometrical risk factors in the appearance of eating disorders in 11 years old children in the prefecture of Ioannina, Greece. Angelopoulos, Peter; Tsitsas, George; Milionis, Haralambos; Blachaki, Chrisanthy; Manios, Yannis // Annals of General Psychiatry;2006 Supplement 1, Vol. 5, pS123 

    A conference paper about the relationships among eating disorders, obesity and psychological factors in primary school children in Greece is presented. Results reveal positive correlations between eating disorders and body mass index, waist circumference, hips circumference, left triceps...

  • Body mass index and breast size in women: same or different genes? Wade, Tracey D; Zhu, Gu; Martin, Nicholas G // Twin Research & Human Genetics;Oct2010, Vol. 13 Issue 5, p450 

    The objective of the current study was to investigate the heritability of breast size and the degree to which this heritability is shared with BMI. In a sample of 1010 females twins (mean age 35 years; SD = 2.1; range 28-40), self-report data pertaining to bra cup size and body mass index (BMI)...

  • Compulsory Treatment for Anorexia Nervosa: Compassion or Coercion? Tiller, Jane; Schmidt, Ulrike; Treasure, Janet // British Journal of Psychiatry;May93, Vol. 162, p679 

    The article examines whether the compulsory treatment for anorexia nervosa is "compassion" or coercion. " The author believes that compulsory treatment should not be entered into lightly, nor should it be reflexly dismissed. This type of treatment involves discussion between the patient, the...

  • Empty Inside.  // Current Health 2;Jan2005, Vol. 31 Issue 5, p19 

    Presents information on several eating disorders.

  • Night eating syndrome and related psychopathology.  // Healthy Weight Journal;Nov/Dec2001, Vol. 15 Issue 6, p82 

    Provides information on night eating disorder (NES). Clinical manifestations of NES; Correlation between NES and obesity.

  • Night Eating Syndrome. Gluck, Marci E. // Healthy Weight Journal;Mar/Apr2002, Vol. 16 Issue 2, p27 

    Presents information on night eating syndrome (NES). Method of diagnosing NES; Details of several studies conducted on NES; Factors that influence the development of NES.

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics