The switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of cognitive deficits. A pilot study in individuals with schizophrenia

Selva-Vera, Gabriel; Balanzá-Martínez, Vicent; Salazar-Fraile, José; Sánchez-Moreno, José; Martinez-Aran, Anabel; Correa, Patricia; Vieta, Eduard; Tabarés-Seisdedos, Rafael
January 2010
BMC Psychiatry;2010, Vol. 10, p47
Academic Journal
Background: Atypical antipsychotics provide better control of the negative and affective symptoms of schizophrenia when compared with conventional neuroleptics; nevertheless, their heightened ability to improve cognitive dysfunction remains a matter of debate. This study aimed to examine the changes in cognition associated with longterm antipsychotic treatment and to evaluate the effect of the type of antipsychotic (conventional versus novel antipsychotic drugs) on cognitive performance over time. Methods: In this naturalistic study, we used a comprehensive neuropsychological battery of tests to assess a sample of schizophrenia patients taking either conventional (n = 13) or novel antipsychotics (n = 26) at baseline and at two years after. Results: Continuous antipsychotic treatment regardless of class was associated with improvement on verbal fluency, executive functions, and visual and verbal memory. Patients taking atypical antipsychotics did not show greater cognitive enhancement over two years than patients taking conventional antipsychotics. Conclusions: Although long-term antipsychotic treatment slightly improved cognitive function, the switch from conventional to atypical antipsychotic treatment should not be based exclusively on the presence of these cognitive deficits.


Related Articles

  • Remediation of memory disorders in schizophrenia. A. MEDALIA; N. REVHEIM; M. CASEY // Psychological Medicine;Nov2000, Vol. 30 Issue 6, p1451 

    No abstract available.

  • The lifetime outcome and involuntary movements of schizophrenia never treated with neuroleptic drugs. Four rare cases in Ireland. Waddington, John L.; Youssef, Hanafy A.; Waddington, J L; Youssef, H A // British Journal of Psychiatry;Jan90, Vol. 156, p106 

    Four elderly schizophrenic patients who had never been treated with neuroleptics, and a fifth patient who had received only the briefest exposure to such drugs, had retained their distinct clinical characteristics. Involuntary orofacial movements and cognitive dysfunction were found more...

  • Neuroleptic dosing in chronic schizophrenia: a 10-year follow-up. Remington, Gary J.; Prendergast, Peter; Bezchlibnyk-Butler, Kalyna Z.; Remington, G J; Prendergast, P; Bezchlibnyk-Butler, K Z // Canadian Journal of Psychiatry;Feb1997, Vol. 42 Issue 1, p53 

    Objective: To evaluate neuroleptic dosing patterns in individuals with schizophrenia over a 10-year interval.Method: Changes in neuroleptic dosing between 1980 and 1990 were followed in 65 patients with a diagnosis of chronic schizophrenia.Results:...

  • Effects of long-term prolactin-raising antipsychotic medication on bone mineral density in patients with schizophrenia. Meaney, A. M.; Smith, S.; Howes, O. D.; O'Brien, M.; Murray, R. M.; O'Keane, V. // British Journal of Psychiatry;Jun2004, Vol. 184, p503 

    Background: High rates of osteoporosis in schizophrenia may result from the prolactin-raising effects of some antipsychotic medication. Aims To examine bone mineral density in relation to relevant endocrine variables in patients with schizophrenia taking prolactin-raising...

  • Non-adherence to antipsychotic medication regimens: associations with resource use and costs. Knapp, Martin; King, Derek; Pugner, Klaus; Lapuerta, Pablo // British Journal of Psychiatry;Jun2004, Vol. 184, p509 

    Background: Several factors are thought to influence resource use and costs in treating schizophrenia.Aims: To assess the relative impact of non-adherence and other factors associated with resource use and costs incurred by people with schizophrenia.Method:...

  • Extrastriatal and striatal D2 dopamine receptor blockade with haloperidol or new antipsychotic drugs in patients with schizophrenia. Xiberas, X.; Martinot, J. L.; Mallet, L.; Artiges, E.; Loc'h, C.; Maziere, B.; Paillère-Martinot, M. L. // British Journal of Psychiatry;Dec2001, Vol. 179, p503 

    Background Both traditional and atypical antipsychotics have been hypothesised to be effective in schizophrenia through fimbic and cortical D2 dopamine receptor blockade. Aims To investigate this hypothesis with the D2/D3-selective positron emission tomography (PET) probe [76Br]-FLB457. Method...

  • Quantitative EEG in Schizophrenic Patients before and during Pharmacotherapy. Begić, Dražen; Hotujac, Ljubomir; Jokić-Begić, Nataša // Neuropsychobiology;2000, Vol. 41 Issue 3, p166 

    The aim of the study was to determine the possible differences in quantitative EEG parameters of schizophrenic patients before and during therapy with neuroleptics. First EEG recordings were obtained from schizophrenic patients (n = 50) who had not been taking any medicaments during the...

  • The Nithsdale Schizophrenia Survey. VII. Does relatives' high expressed emotion predict relapse? McCreadie, R. G.; Phillips, K. // British Journal of Psychiatry;Apr88, Vol. 152, p477 

    A review of all known schizophrenic people living in Nithsdale in South-West Scotland identified long-stay in-patients, patients living on their own and those living with relatives showing low or high expressed emotion (EE). A prospective 12-month follow-up identified relapsing patients, defined...

  • COGNITIVE IMPAIRMENTAND PERCEIVED STRESS IN SCHIZOPHRENIC INPATIENTS WITH POST-TRAUMATIC STRESS DISORDER. Pollice, R.; Bianchini, V.; Conti, C. M.; Mazza, M.; Roncone, R.; Casacchia, M. // European Journal of Inflammation (BIOLIFE, s.a.s.);Sep-Dec2010, Vol. 8 Issue 3, p211 

    The rate of lifetime traumas in the general population is high and a great deal of evidence suggests that persons with severe mental illness (SMI) show an even higher degree of vulnerability to trauma throughout their lives. Recent studies report between 13 and 29% of comorbid Post-Traumatic...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics