TITLE

Recombination facilitates neofunctionalization of duplicate genes via originalization

AUTHOR(S)
Cheng Xue; Ren Huang; Shu-Qun Liu; Yun-Xin Fu
PUB. DATE
January 2010
SOURCE
BMC Genetics;2010, Vol. 11, p46
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Recently originalization was proposed to be an effective way of duplicate-gene preservation, in which recombination provokes the high frequency of original (or wild-type) allele on both duplicated loci. Because the high frequency of wild-type allele might drive the arising and accumulating of advantageous mutation, it is hypothesized that recombination might enlarge the probability of neofunctionalization (Pneo) of duplicate genes. In this article this hypothesis has been tested theoretically. Results: Results show that through originalization recombination might not only shorten mean time to neofunctionalizaiton, but also enlarge Pneo. Conclusions: Therefore, recombination might facilitate neofunctionalization via originalization. Several extensive applications of these results on genomic evolution have been discussed: 1. Time to nonfunctionalization can be much longer than a few million generations expected before; 2. Homogenization on duplicated loci results from not only gene conversion, but also originalization; 3. Although the rate of advantageous mutation is much small compared with that of degenerative mutation, Pneo cannot be expected to be small.
ACCESSION #
52798508

 

Related Articles

  • Selective constraint, background selection, and mutation accumulation variability within and between human populations. Hodgkinson, Alan; Casals, Ferran; Idaghdour, Youssef; Grenier, Jean-Christophe; Hernandez, Ryan D.; Awadalla, Philip // BMC Genomics;2013, Vol. 14 Issue 1, p1 

    Background: Regions of the genome that are under evolutionary constraint across multiple species have previously been used to identify functional sequences in the human genome. Furthermore, it is known that there is an inverse relationship between evolutionary constraint and the allele frequency...

  • Redistribution of Gene Frequency and Changes of Genetic Variation Following a Bottleneck in Population Size. Xu-Sheng Zhang; Jinliang Wang; Hill, William G. // Genetics;Jul2004, Vol. 167 Issue 3, p1475 

    Although the distribution of frequencies of genes influencing quantitative traits is important to our understanding of their genetic basis and their evolution, direct information from laboratory experiments is very limited. In theory, different models of selection and mutation generate different...

  • Mutational load analysis of unrelated individuals. Howrigan, Daniel P.; Simonson, Matthew A.; Kamens, Helen M.; Stephens, Sarah H.; Wills, Amanda G.; Ehringer, Marissa A.; Keller, Matthew C.; McQueen, Matthew B. // BMC Proceedings;2011 Supplement 9, Vol. 5 Issue Suppl 9, p1 

    Evolutionary genetic models predict that the cumulative effect of rare deleterious mutations across the genome-known as mutational load burden-increases the susceptibility to complex disease. To test the mutational load burden hypothesis, we adopted a two-tiered approach: assessing the impact of...

  • Weak Selection and Protein Evolution. Akashi, Hiroshi; Osada, Naoki; Ohta, Tomoko // Genetics;Sep2012, Vol. 192 Issue 1, p15 

    The "nearly neutral" theory of molecular evolution proposes that many features of genomes arise from the interaction of three weak evolutionary forces: mutation, genetic drift, and natural selection acting at its limit of efficacy. Such forces generally have little impact on allele frequencies...

  • Estimating Mutation Parameters, Population History and Genealogy Simultaneously From Temporally Spaced Sequence Data. Drummond, Alexei J.; Nicholls, Geoff K.; Rodrigo, Allen G.; Solomon, Wiremu // Genetics;Jul2002, Vol. 161 Issue 3, p1308 

    Investigates the process of estimating mutation parameters, population history and genealogy simultaneosly from temporally spaced sequence data. Application of the Bayesian statistical approach of estimation of mutation rate; Use of the Kingman coalescent model to describe the time element;...

  • Whole-Genome Sequencing in a Patient with Charcot�Marie�Tooth Neuropathy. Lupski, James R.; Reid, Jeffrey G.; Gonzaga-Jauregui, Claudia; Deiros, David Rio; Chen, David C. Y.; Nazareth, Lynne; Bainbridge, Matthew; Dinh, Huyen; Chyn Jing; Wheeler, David A.; McGuire, Amy L.; Feng Zhang; Stankiewicz, Pawel; Halperin, John J.; Yang, Chengyong; Gehman, Curtis; Guo, Danwei; Irikat, Rola K.; Tom, Warren; Fantin, Nick J. // New England Journal of Medicine;4/1/2010, Vol. 362 Issue 13, p1181 

    Background: Whole-genome sequencing may revolutionize medical diagnostics through rapid identification of alleles that cause disease. However, even in cases with simple patterns of inheritance and unambiguous diagnoses, the relationship between disease phenotypes and their corresponding genetic...

  • Bambino: a variant detector and alignment viewer for next-generation sequencing data in the SAM/BAM format. Edmonson, Michael N.; Zhang, Jinghui; Yan, Chunhua; Finney, Richard P.; Meerzaman, Daoud M.; Buetow, Kenneth H. // Bioinformatics;Mar2011, Vol. 27 Issue 6, p865 

    Summary: Bambino is a variant detector and graphical alignment viewer for next-generation sequencing data in the SAM/BAM format, which is capable of pooling data from multiple source files. The variant detector takes advantage of SAM-specific annotations, and produces detailed output suitable...

  • A Comprehensive Map of Mobile Element Insertion Polymorphisms in Humans. Stewart, Chip; Kural, Deniz; Strömberg, Michael P.; Walker, Jerilyn A.; Konkel, Miriam K.; Stütz, Adrian M.; Urban, Alexander E.; Grubert, Fabian; Lam, Hugo Y. K.; Lee, Wan-Ping; Busby, Michele; Indap, Amit R.; Garrison, Erik; Huff, Chad; Xing, Jinchuan; Snyder, Michael P.; Jorde, Lynn B.; Batzer, Mark A.; Korbel, Jan O.; Marth, Gabor T. // PLoS Genetics;Aug2011, Vol. 7 Issue 8, Special section p1 

    As a consequence of the accumulation of insertion events over evolutionary time, mobile elements now comprise nearly half of the human genome. The Alu, L1, and SVA mobile element families are still duplicating, generating variation between individual genomes. Mobile element insertions (MEI) have...

  • Climbing Mount Probable: Mutation as a Cause of Nonrandomness in Evolution. Stoltzfus, Arlin; Yampolsky, Lev Y. // Journal of Heredity;Sep/Oct2009, Vol. 100 Issue 5, p637 

    The classic view of evolution as "shifting gene frequencies" in the Modern Synthesis literally means that evolution is the modulation of existing variation ("standing variation"), as opposed to a "new mutations" view of evolution as a 2-step process of mutational origin followed by...

Share

Other Topics