Changes of Inflammatory Mediators in Obese Patients After Laparoscopic Cholecystectomy

Vita, Gaetano Di; Patti, Rosalia; Famà, Fausto; Balistreri, Carmela Rita; Candore, Giuseppina; Caruso, Calogero
September 2010
World Journal of Surgery;Sep2010, Vol. 34 Issue 9, p2045
Academic Journal
Obesity is associated with the impairment of immunological functions. The aim of this study was to analyze some inflammatory mediators in obese subjects who underwent laparoscopic cholecystectomy. Seventeen consecutive female patients with a BMI ranging from 35 to 45 kg/m2 (obese) and 17 consecutive female patients with BMI ranging from 20 to 25 kg/m2 (nonobese) were included in the study. All patients were affected by symptomatic gallbladder stone disease and underwent laparoscopic cholecystectomy. Changes in levels of leukocytes, neutrophils, IL-6, IL-10, leptin, and adiponectin were evaluated. We observed a significant increase in leukocyte and neutrophil levels in the obese subjects compared to the nonobese subjects. The serum levels of leptin and IL-6 were higher in the postoperative period (compared to the baseline values in both groups), and always higher in the obese. Both adiponectin and IL-10 increased in the postoperative period in nonobese subjects and was always higher than in the obese. Obese patients have a stronger acute inflammatory response than do nonobese subjects in reaction to surgical stress.


Related Articles

  • Central adiposity, regional fat distribution, and the risk of cholecystectomy in women. Tsai, C.-I.; Leitzmann, M. F.; Willett, W. C.; Giovannucci, E. L. // Gut;May2006, Vol. 55 Issue 5, p708 

    Purpose: Whether central adiposity contributes independently of total adiposity to the risk for gall stones is inconclusive. We examined prospectively indicators of central adiposity in relation to the occurrence of gall stone disease. Methods: We evaluated the relationship between abdominal...

  • The impact of body mass index on outcomes after laparoscopic cholecystectomy. Farkas, Daniel; Moradi, Dovid; Moaddel, David; Nagpal, Kamal; Cosgrove, John // Surgical Endoscopy;Apr2012, Vol. 26 Issue 4, p964 

    Background: Laparoscopic cholecystectomy (LC) is the standard of care for gallstone disease. Some cases will be converted to open surgery and others will have complications, both leading to worse outcomes. The purpose of this study was to evaluate whether an increased body mass index (BMI) is...

  • The quality of cholecystectomy in Denmark: outcome and risk factors for 20,307 patients from the national database. Harboe, Kirstine Moll; Bardram, Linda // Surgical Endoscopy;May2011, Vol. 25 Issue 5, p1630 

    Background: Laparoscopic cholecystectomy is the standard treatment for symptomatic gallstones. The quality of the procedure frequently is included in quality improvement programs, but outcome values have not been described to define the standard of care for a general population. This study...

  • Scarless Cholecystectomy with Standard Laparoscopic Instruments in Selected Patients. Aminian, Ali; Mishra, R. K.; Mirsharifi, Rasoul // World Journal of Laparoscopic Surgery;Sep-Dec2011, Vol. 4 Issue 3, p129 

    Laparoscopic cholecystectomy is a gold standard for treatment of gallstone-related diseases. We have now modified this technique and introduced scarless cholecystectomy with standard laparoscopic instruments. Patients with normal body mass index and with no previous history of acute...

  • Robotic Single- and Multisite Cholecystectomy in Children. Ahn, Nicholas; Signor, Gary; Singh, Tejinder Paul; Stain, Steven; Whyte, Christine // Journal of Laparoendoscopic & Advanced Surgical Techniques;Dec2015, Vol. 25 Issue 12, p1033 

    Background: Elective cholecystectomy is a high-volume, simple procedure, well suited for the development of a pediatric robotic surgery program. Surgical robot software, by "reversing" the surgeon's hands, simplifies single-site cholecystectomy through a single incision at the...

  • Obesity Not Necessary, Risk of Symptomatic Cholelithiasis Increases as a Function of BMI. KHARGA, BIKRAM; SHARMA, BARUN KUMAR; NISHANT, KUMAR; SINGH, VARUN KUMAR; BHUTIA, PHUCHUNGLA; TAMANG, ROSHAN; JAIN, NITIN // Journal of Clinical & Diagnostic Research;Oct2016, Vol. 10 Issue 10, p28 

    Introduction: Obesity is a well-established risk factor for cholelithiasis. But most of the studies have actually tried to establish the risk of cholelithiasis in overweight and obese people. Very few studies have addressed the issue of cholelithiasis in patients with otherwise normal Body Mass...

  • A Case of Duodenal Obstruction and Pancreatitis Due to Intragastric Balloon. Öztürk, Alaattin; Yavuz, Yunus; Atalay, Talha // Balkan Medical Journal;2015, Vol. 32 Issue 3, p323 

    Background: Intragastric balloons have several advantages such as easy placement and low complication rates over other bariatric procedures. It is very rare for intragastric balloons to dislodge and give rise to pancreatitis. In this article, we present a case of duodenal obstruction caused by a...

  • Is esophagogastroduodenoscopy essential prior to the elective surgical therapy of symptomatic cholelithaisis? Mozafar, Mohamad; Sobhiyeh, Mohamad Reza; Heibatollahi, Motahare // Gastroenterology & Hepatology from Bed to Bench;Apr2010, Vol. 3 Issue 2, p77 

    Aim: To determine the co-incidence of gallstones with upper GI disease in patients who were candidate for elective cholecystectomy. Background: Typical pain of gallstones frequently cause special pattern which can usually be distinguished from symptoms of other organic and functional diseases....

  • Factors predicting difficult laparoscopic cholecystectomy: a single-institution experience. Dhanke, Prashant S.; Ugane, Subodh P. // International Journal of Students' Research;2014, Vol. 4 Issue 1, p3 

    Introduction: Cholelithiasis is the most common biliary pathology, with prevalence of 10-15%. In 1992, National Institute of Health consensus development stated that laparoscopic cholecystectomy "provides a safe and effective treatment for most patients with symptomatic gallstones" and it is the...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics