Glycaemic fluctuation predicts mortality in critically ill patients

July 2010
Anaesthesia & Intensive Care;Jul2010, Vol. 38 Issue 4, p695
Academic Journal
The article discusses a study that evaluated the predictors of glycaemic fluctuation and its relation to critical care outcomes. It describes a nested-cohort study within a clinical trial in which medical surgical intensive care patients were randomized to either intensive insulin therapy or conventional insulin therapy. The mean difference between the highest and lowest daily blood glucose is used as the benchmark for glycaemic fluctuation. Glycaemic fluctuation is identified as a predictor of intensive care unit mortality and hospital mortality.


Related Articles

  • Permissive underfeeding versus target enteral feeding in adult critically ill patients (PermiT Trial): a study protocol of a multicenter randomized controlled trial. Arabi, Yaseen M.; Haddad, Samir H.; Aldawood, Abdulaziz S.; Al-Dorzi, Hasan M.; Tamim, Hani M.; Sakkijha, Maram; Jones, Gwynne; McIntyre, Lauralyn; Mehta, Sangeeta; Solaiman, Othman; Sadat, Musharaf; Afesh, Lara; Sami, Bushra // Trials;2012, Vol. 13 Issue 1, p191 

    Background: Nutritional support is an essential part of the management of critically ill patients. However, optimal caloric intake has not been systematically evaluated. We aim to compare two strategies of enteral feeding: permissive underfeeding versus target feeding. Method/Design: This is an...

  • Effect of an Intensive Glucose Management Protocol on the Mortality of Critically Ill Adult Patients. Krinsley, James Stephen // Mayo Clinic Proceedings;Aug2004, Vol. 79 Issue 8, p992 

    OBJECTIVE: To assess the effect of an Intensive glucose management protocol In a heterogeneous population of critically III adult patients. PATIENTS AND METHODS: This study consisted of 800 consecutive patients admitted after Institution of the protocol (treatment group, between February 1,...

  • Duration of Time on Intensive Insulin Therapy Predicts Severe Hypoglycemia in the Surgically Critically Ill Population. Mowery, Nathan; Gunter, Oliver; Kauffmann, Rondi; Diaz, Jose; Collier, Bryan; May, Addison // World Journal of Surgery;Feb2012, Vol. 36 Issue 2, p270 

    Background: Hypoglycemia has emerged as a barrier to the practice of intensive insulin therapy. Current literature suggests that hypoglycemia occurs at variable rates and has different effects on outcomes in surgical and medical populations. We sought to determine the incidence, independent...

  • Intensive versus Conventional Glucose Control in Critically Ill Patients.  // New England Journal of Medicine;3/26/2009, Vol. 360 Issue 13, p1283 

    The article presents a randomized, controlled trial that tested the effects of intensive versus conventional glucose control in critically ill patients. Adult medical and surgical patients expected to require treatment in the intensive care unit on three or more consecutive days were eligible...

  • Influence of Individual Characteristics on Outcome of Glycemic Control in Intensive Care Unit Patients With or Without Diabetes Mellitus. Rady, Mohamed Y.; Johnson, Daniel J.; Patel, Bhavesh M.; Larson, Joel S.; Helmers, Richard A. // Mayo Clinic Proceedings;Dec2005, Vol. 80 Issue 12, p1558 

    OBJECTIVE: To clarify the relationship of patient and critical illness characteristics (including any history of diabetes mellitus) to glycemic control with insulin and hospital mortality. PATIENTS AND METHODS: A case-control descriptive study was performed of patients admitted to a...

  • Tight Blood Glucose Control With Insulin in "Real-Life" Intensive Care. Van den Berghe, Greet // Mayo Clinic Proceedings;Aug2004, Vol. 79 Issue 8, p977 

    Editorial. Comments on J.S. Krinsley and colleagues' study of the effect of an intensive glucose management protocol on the mortality of critically ill adult patients. Clinical outcome of patients before and after implementing the standard of care, tighter insulin-titrated glycemic control;...

  • Does glycemic control with insulin therapy play a role for critically ill patients in hospital? Patel, Arpita H.; Pittas, Anastassios G. // CMAJ: Canadian Medical Association Journal;3/28/2006, Vol. 174 Issue 7, p917 

    Analyzes the significance of glycemic control to critically ill hospital patients. Use of insulin therapy to control hyperglycemia; Overview of studies on the clinical importance of glycemic control; Mechanisms that explain the benefits of insulin therapy and glycemic control in critically ill...

  • Introducing Critical Care Outreach: a ward-randomised trial of phased introduction in a general hospital. Priestley, George; Watson, Wendy; Rashidian, Arash; Mozley, Caroline; Russell, Daphne; Wilson, Jonathan; Cope, Judith; Hart, Dianne; Kay, Diana; Cowley, Karen; Pateraki, Jayne // Intensive Care Medicine;Jul2004, Vol. 30 Issue 7, p1398 

    Objective: The purpose of the study was to investigate the effects of introducing a critical care outreach service on in-hospital mortality and length of stay in a general acute hospital.Design: A pragmatic ward-randomised trial design was used, with intervention...

  • The use of propofol for medium and long-term sedation in critically ill adult patients: a meta-analysis. Ho, Kwok; Ng, Joseph // Intensive Care Medicine;Nov2008, Vol. 34 Issue 11, p1969 

    To investigate the effects of using propofol for medium and long-term sedation on mortality and length of intensive care unit (ICU) stay of critically ill adult patients. Randomised controlled studies comparing propofol with an alternative sedative agent in critically ill adult patients were...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics