TITLE

Seasonal Influenza Vaccine and Protection against Pandemic (H1N1) 2009-Associated Illness among US Military Personnel

AUTHOR(S)
Johns, Matthew C.; Eick, Angelia A.; Blazes, David L.; Seung-eun Lee; Perdue, Christopher L.; Lipnick, Robert; Vest, Kelly G.; Russell, Kevin L.; DeFraites, Robert F.; Sanchez, Jose L.
PUB. DATE
May 2010
SOURCE
PLoS ONE;2010, Vol. 5 Issue 5, p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Introduction: A novel A/H1N1 virus is the cause of the present influenza pandemic; vaccination is a key countermeasure, however, few data assessing prior seasonal vaccine effectiveness (VE) against the pandemic strain of H1N1 (pH1N1) virus are available. Materials and Methods: Surveillance of influenza-related medical encounter data of active duty military service members stationed in the United States during the period of April-October 2009 with comparison of pH1N1-confirmed cases and location and date-matched controls. Crude odds ratios (OR) and VE estimates for immunized versus non-immunized were calculated as well as adjusted OR (AOR) controlling for sex, age group, and history of prior influenza vaccination. Separate stratified VE analyses by vaccine type (trivalent inactivated [TIV] or live attenuated [LAIV]), age groups and hospitalization status were also performed. For the period of April 20 to October 15, 2009, a total of 1,205 cases of pH1N1-confirmed cases were reported, 966 (80%) among males and over one-half (58%) under 25 years of age. Overall VE for service members was found to be 45% (95% CI, 33 to 55%). Immunization with prior season's TIV (VE = 44%, 95% CI, 32 to 54%) as well as LAIV (VE = 24%, 95% CI, 6 to 38%) were both found to be associated with protection. Of significance, VE against a severe disease outcome was higher (VE = 62%, 95% CI, 14 to 84%) than against milder outcomes (VE = 42%, 95% CI, 29 to 53%). Conclusion: A moderate association with protection against clinically apparent, laboratory-confirmed Pandemic (H1N1) 2009-associated illness was found for immunization with either TIV or LAIV 2008-09 seasonal influenza vaccines. This association with protection was found to be especially apparent for severe disease as compared to milder outcome, as well as in the youngest and older populations. Prior vaccination with seasonal influenza vaccines in 2004-08 was also independently associated with protection.
ACCESSION #
52682309

 

Related Articles

  • Influenza vax coverage still low in many countries.  // PharmacoEconomics & Outcomes News;5/28/2011, Issue 629, p7 

    The article discusses three studies on seasonal and pandemic influenza vaccines. One of the studies discovered that the acceptance of pediatric H1N1 influenza vaccination among minority parents of children six months to 18 years in the U.S. is low. A study that examined influenza vaccine...

  • Induction of Heterosubtypic Cross-Protection against Influenza by a Whole Inactivated Virus Vaccine: The Role of Viral Membrane Fusion Activity. Budimir, Natalija; Huckriede, Anke; Meijerhof, Tjarko; Boon, Louis; Gostick, Emma; Price, David A.; Wilschut, Jan; de Haan, Aalzen // PLoS ONE;Jan2012, Vol. 7 Issue 1, p1 

    Background: The inability of seasonal influenza vaccines to effectively protect against infection with antigenically drifted viruses or newly emerging pandemic viruses underlines the need for development of cross-reactive influenza vaccines that induce immunity against a variety of virus...

  • Influenza cases build across country.  // American Nurse;Jan/Feb2015, Vol. 47 Issue 1, p5 

    The article reports that widespread influenza activity was recorded in 44 U.S. states in January 2015 according to the Centers for Disease Control and Prevention (CDC), and mentions topics including CDC recommendations to avoid flu complications, H3N2 viruses, and flu-associated pediatric deaths.

  • Influence of the H1N1 Pandemic on University Students' Knowledge of Influenza. Schlenker, Evelyn H.; Tschetter, Rachel L.; Straub, Holly R. // South Dakota Medicine;Nov2013, Vol. 66 Issue 11, p449 

    Background Avoidance of influenza among college students requires understanding the risks for falling ill, outcomes of this disease, and utilizing methods to prevent developing influenza. We hypothesized that the behavior and knowledge of college students in the midst of a pandemic situation...

  • The flu shot remains a vital healthcare tool. Sanders, Lori // Clinical Advisor;Dec2015, Vol. 18 Issue 12, p91 

    No abstract available.

  • Live Attenuated Influenza Vaccine (Fluenzâ„¢): A Guide to its Use in the Prevention of Seasonal Influenza in Children in the EU. Scott, Lesley J.; Carter, Natalie J.; Curran, Monique P. // Pediatric Drugs;8/1/2012, Vol. 14 Issue 4, p271 

    Live attenuated influenza vaccine (LAIV) [Fluenzâ„¢] has a convenient intranasal route of administration. In the EU, it is indicated for the prevention of influenza disease caused by the influenza virus strains contained in the vaccine in children and adolescents aged 2 years to <18 years....

  • Cross Sectional Survey of Influenza Antibodies before and during the 2009 Pandemic in Shenzhen, China. Chun-Li Wu; Juan Lu; Wang, Maggie Haitian; Xing Lv; Ying Chen; Hsiang-fu Kung; Zee, Benny; Xiao-wen Cheng; Ming-Liang He // PLoS ONE;Jan2013, Vol. 8 Issue 1, Special section p1 

    Much information is available for the 2009 H1N1 influenza immunity response, but little is known about the antibody change in seasonal influenza before and during the novel influenza A pandemic. In this study, we conducted a cross-sectional serological survey of 4 types of major seasonal...

  • The Lao Experience in Deploying Influenza A(H1N1)pdm09 Vaccine: Lessons Made Relevant in Preparing for Present Day Pandemic Threats. Xeuatvongsa, Anonh; Mirza, Sara; Winter, Christian; Feldon, Keith; Vongphrachanh, Phengta; Phonekeo, Darouny; Denny, Justin; Khanthamaly, Viengphone; Kounnavong, Bounheuang; Lylianou, Doualy; Phousavath, Sisouphane; Norasingh, Sisouveth; Boutta, Nao; Olsen, Sonja; Bresee, Joseph; Moen, Ann; Corwin, Andrew // PLoS ONE;Apr2015, Vol. 10 Issue 4, p1 

    The Lao PDR, as did most countries of the Mekong Region, embarked on a pandemic vaccine initiative to counter the threat posed by influenza A(H1N1)pdm09. Overall, estimated vaccine coverage of the Lao population was 14%, with uptake in targeted health care workers and pregnant women 99% and 41%,...

  • Registry-Based Surveillance of Influenza-Associated Hospitalisations during the 2009 Influenza Pandemic in Denmark: The Hidden Burden on the Young. Widgren, Katarina; Nielsen, Jens; Mølbak, Kåre // PLoS ONE;2010, Vol. 5 Issue 11, p1 

    Background: To follow the impact of the 2009 influenza pandemic in Denmark, influenza surveillance was extended with a system monitoring potentially influenza-associated hospitalisations. Methodology/Principal Findings: National administrative data from 2004-2010 from the automatic reporting of...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics