Rola adipokin w przewlekłych chorobach wątroby

Piekarska, Anna; Wójcik, Kamila
March 2010
Gastroenterologia Polska / Gastroenterology;2010, Vol. 17 Issue 2, p138
Academic Journal
Adipose tissue secretes a number of cytokines which are called adipokines. They regulate metabolic, immunologic, and inflammatory processes: Abnormalities in adipokine secretion contribute to insulin resistance and metabolic syndrome. Here we review the structure and physiological roles of such adipokines as leptin, adiponectin, resistin, visfatin, and retinol-binding protein 4 (RBP-4). The pathogenesis of nonalcoholic fatty liver disease (NAFLD) based on insulin resistance is associated with adipokine secretion and oxidative stress leading to the production of proinflammatory cytokines. Adipokines, especially adiponectin, resistin, visfatin, leptin, TNF-α, and IL-6, play a crucial role in the development of NAFLD. The core protein of HCV causes significant metabolic abnormalities, with interference in lipid metabolism and the expression and activity of adipokines. The influence of these substances and diet supplements on adipokine profile and the sustained viral response in patients with chronic hepatitis C remains questionable and seems to be a promising therapeutic option.


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