TITLE

Rola adipokin w przewlekłych chorobach wątroby

AUTHOR(S)
Piekarska, Anna; Wójcik, Kamila
PUB. DATE
March 2010
SOURCE
Gastroenterologia Polska / Gastroenterology;2010, Vol. 17 Issue 2, p138
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Adipose tissue secretes a number of cytokines which are called adipokines. They regulate metabolic, immunologic, and inflammatory processes: Abnormalities in adipokine secretion contribute to insulin resistance and metabolic syndrome. Here we review the structure and physiological roles of such adipokines as leptin, adiponectin, resistin, visfatin, and retinol-binding protein 4 (RBP-4). The pathogenesis of nonalcoholic fatty liver disease (NAFLD) based on insulin resistance is associated with adipokine secretion and oxidative stress leading to the production of proinflammatory cytokines. Adipokines, especially adiponectin, resistin, visfatin, leptin, TNF-α, and IL-6, play a crucial role in the development of NAFLD. The core protein of HCV causes significant metabolic abnormalities, with interference in lipid metabolism and the expression and activity of adipokines. The influence of these substances and diet supplements on adipokine profile and the sustained viral response in patients with chronic hepatitis C remains questionable and seems to be a promising therapeutic option.
ACCESSION #
52678430

 

Related Articles

  • HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice. Joyce, Michael A.; Walters, Kathie-Anne; Lamb, Sue-Ellen; Yeh, Mathew M.; Lin-Fu Zhu; Kneteman, Norman; Doyle, Jason S.; Katze, Michael G.; Tyrrell, D. Lorne // PLoS Pathogens;Feb2009, Vol. 5 Issue 2, p1 

    Hepatitis C virus (HCV) is a blood-borne pathogen and a major cause of liver disease worldwide. Gene expression profiling was used to characterize the transcriptional response to HCV H77c infection. Evidence is presented for activation of innate antiviral signaling pathways as well as induction...

  • Hepatitis C Virus, Oxidative Stress and Steatosis: Current Status and Perspectives. González-Gallego, J.; García-Mediavilla, M. V.; Sánchez-Campos, S. // Current Molecular Medicine;Jul2011, Vol. 11 Issue 5, p373 

    Reactive oxygen and nitrogen species (ROS/RNS), whether produced endogenously as a consequence of normal cell functions or derived from external sources, pose a constant threat to cells living in an aerobic environment. When the production of ROS/RNS overrides the antioxidant capability of the...

  • A crucial role for adipose tissue p53 in the regulation of insulin resistance. Minamino, Tohru; Orimo, Masayuki; Shimizu, Ippei; Kunieda, Takeshige; Yokoyama, Masataka; Ito, Takashi; Nojima, Aika; Nabetani, Akira; Oike, Yuichi; Matsubara, Hisahiro; Ishikawa, Fuyuki; Komuro, Issei // Nature Medicine;Sep2009, Vol. 15 Issue 9, p1082 

    Various stimuli, such as telomere dysfunction and oxidative stress, can induce irreversible cell growth arrest, which is termed 'cellular senescence'. This response is controlled by tumor suppressor proteins such as p53 and pRb. There is also evidence that senescent cells promote changes related...

  • Nutrient sensor links obesity with diabetes risk. Patti, Mary-Elizabeth; Kahn, Barbara B. // Nature Medicine;Oct2004, Vol. 10 Issue 10, p1049 

    Reports on the finding that a component of the mTOR nutrient signaling pathway now bridges the mechanistic gap between obesity and insulin resistance. Development of insulin resistance and diabetes due to overeating; Role for altered lipid metabolism in impaired insulin signaling; Recognition...

  • Global Gene Expression Profiles of Subcutaneous Adipose and Muscle From Glucose-Tolerant, Insulin-Sensitive, and Insulin-Resistant Individuals Matched for BMI. Elbein, Steven C.; Kern, Philip A.; Rasouli, Neda; Yao-Borengasser, Aiwei; Sharma, Neeraj K.; Das, Swapan K. // Diabetes;Mar2011, Vol. 60 Issue 3, p1019 

    OBJECTIVE--To determine altered gene expression profiles in subcutaneous adipose and skeletal muscle from nondiabetic, insulin-resistant individuals compared with insulin-sensitive individuals matched for BMI. RESEARCH DESIGN AND METHODS--A total of 62 nondiabetic individuals were chosen for...

  • White Adipose Tissue Resilience to Insulin Deprivation and Replacement. Hadji, Lilas; Berger, Emmanuelle; Soula, Hédi; Vidal, Hubert; Géloën, Alain // PLoS ONE;Aug2014, Vol. 9 Issue 8, p1 

    Introduction: Adipocyte size and body fat distribution are strongly linked to the metabolic complications of obesity. The aim of the present study was to test the plasticity of white adipose tissue in response to insulin deprivation and replacement. We have characterized the changes of adipose...

  • Hepatitis C and hepatic steatosis. Patel, J. H.; Cobbold, J. F. L.; Thomas, H. C.; Taylor-Robinson, S. D. // QJM: An International Journal of Medicine;May2010, Vol. 103 Issue 5, p293 

    Hepatic steatosis is commonly seen in patients with chronic hepatitis C infection, and the two together have a greater association than by chance alone. Hepatitis C virus is closely associated with lipid metabolism throughout its lifecycle. Hepatic steatosis is more common in genotype 3...

  • Leptin administration restores the altered adipose and hepatic expression of aquaglyceroporins improving the non-alcoholic fatty liver of ob/ob mice. Rodríguez, Amaia; Méndez-Giménez, Leire; Becerril, Sara; Catalán, Victoria; Gómez-Ambrosi, Javier; Moreno, Natalia R.; Balaguer, Inmaculada; Portincasa, Piero; Calamita, Giuseppe; Soveral, Graça; Malagón, María M.; Frühbeck, Gema // Scientific Reports;7/10/2015, p12067 

    Glycerol is an important metabolite for the control of lipid accumulation in white adipose tissue (WAT) and liver. We aimed to investigate whether exogenous administration of leptin improves features of non-alcoholic fatty liver disease (NAFLD) in leptin-deficient ob/ob mice via the regulation...

  • DJ-1 contributes to adipogenesis and obesity-induced inflammation. Jung-Min Kim; Hyun-Jun Jang; Soo Youn Choi; Soo-Ah Park; Il Shin Kim; Yong Ryoul Yang; Yong Hwa Lee; Sung Ho Ryu; Pann-Ghill Suh // Scientific Reports;6/13/2014, p1 

    Adipose tissue functions as an endocrine organ, and the development of systemic inflammation in adipose tissue is closely associated with metabolic diseases, such as obesity and insulin resistance. Accordingly, the fine regulation of the inflammatory response caused by obesity has therapeutic...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics