Przypuszczalny związek adherentno-inwazyjnych szczepów Escherichia coil (AlEC) z chorobą Leśniowskiego-Crohna

Sobieszczańska, Beata Magdalena; Mokracka-Latajka, Grażyna
March 2010
Gastroenterologia Polska / Gastroenterology;2010, Vol. 17 Issue 2, p116
Academic Journal
Many papers describing the unknown mechanism of Leśniowski-Crohn disease implicate bacteria as a possible factor inducing immunological disorders in the intestinal mucosa. Many species of bacteria are considered to be responsible for the immunological disorders in Leśniowski-Crohn's disease, but Escherichia coil bacilli and Mycobacterium paratuberculosis are the most commonly investigated species. E. coli are the most prevalent among microaerophilic and anaerobic bacteria in the bowels of patients with chronic as well as early Leśniowski-Crohn disease. Antigens of E. coli have been detected in 70% of samples obtained from mucosa of patients with Leśniowski-Crohn disease. The bacilli were also isolated from macrophages residing in the lamina propria of intestinal mucosa of patients with the disease. Serological investigations have revealed that E. coli specific antibodies are present at higher levels in patients with Leśniowski-Crohn than in healthy controls.


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