Increase in transforming growth factor β-1, laminin, and hyaluronic acid serum concentrations in advanced chronic pancreatitis

Adrych, Krystian
March 2010
Gastroenterologia Polska / Gastroenterology;2010, Vol. 17 Issue 2, p98
Academic Journal
Introduction and aim of the study: Studies indicate that transforming growth factor β-1 (TGF-β-1) may play an important role in pancreatic fibrosis during the course of chronic pancreatitis. Thus it can be expected that chronic pancreatitis may be associated with an increase in serum TGF-β1 and markers of extracellular matrix proliferation. The aim of this study was to test this hypothesis. Material and methods: Twenty-three nondiabetic male patients with a history of chronic alcoholic pancreatitis and 16 healthy subjects were examined. Serum TGF-β1, laminin, and hyaluronic acid concentrations were determined by ELISA. Results: The patients with advanced chronic pancreatitis had significantly higher serum TGF-β1 concentrations than the control subjects. The concentrations of both serum laminin and hyaluronic acid (considered to be markers of extracellular matrix proliferation in pancreatic fibrosis) were also elevated in the patients with chronic pancreatitis. Conclusions: These results provide further evidence that TGF-β1 may play an important role in pancreatic fibrosis during the course of chronic pancreatitis. Moreover, it can be supposed that the measurement of serum hyaluronic acid, laminin, and TGF-β1 could be useful for the noninvasive detection of pancreatic fibrosis during the course of chronic pancreatitis.


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