Trends in Antimicrobial Susceptibility of Streptococcus pneumoniae in the Tohoku District of Japan: A Longitudinal Analysis from 1998 to 2007

Suzuki, Kazumasa; Nishimaki, Katsushi; Okuyama, Kaori; Katoh, Tadashi; Yasujima, Minoru; Chihara, Junichi; Suwabe, Akira; Shibata, Yoko; Takahashi, Choichiro; Takeda, Hiroaki; Ida, Shiro; Kaku, Mitsuo; Watanabe, Akira; Nukiwa, Toshihiro; Niitsuma, Kazunao; Kanemitsu, Keiji; Takayanagi, Motoaki; Ohno, Isao
January 2010
Tohoku Journal of Experimental Medicine;Jan2010, Vol. 220 Issue 1, p47
Academic Journal
Streptococcus pneumoniae is a common cause of respiratory tract infections (RTIs). The prevalence of Streptococcus pneumoniae strains with reduced susceptibility to antimicrobial agents has dramatically increased worldwide. Susceptibility to nine antimicrobial agents and serotypes were determined among 1,644 Streptococcus pneumoniae strains isolated from patients with RTIs in the Tohoku district of Japan from October to December every year from 1998 to 2007. The prevalence of penicillin G-nonsusceptible Streptococcus pneumoniae (PNSP) strains increased gradually from 48.5% in 1998, reached a statistical peak in 2004 (65.1%) and then decreased to 51.5% in 2007. Streptococcus pneumoniae strains with each serotype 3, 6, 19 and 23 were constantly detected, and the distribution of these serotypes in PNSP strains did not significantly change during the study period. A trend of Streptococcus pneumoniae strains nonsusceptible to other β-lactams tested was similar to that of PNSP strains, except for cefditoren, to which the resistance rate was < 20% throughout the analysis period. The prevalence of strains nonsusceptible to erythromycin and minocycline were consistently > 60%. Almost all penicillin G-resistant Streptococcus pneumoniae (PRSP) strains were resistant to both erythromycin and minocycline throughout the analysis period. The prevalence of strains resistant to fluoroquinolones tested were < 3% over the study period. Our longitudinal surveillance demonstrated for the first time that decreased prevalence of both β-lactam- and multidrug-resistant strains has been occurring since 2004 in a region of Japan. Careful monitoring of antimicrobial susceptibility of Streptococcus pneumoniae should be continued.


Related Articles

  • Antimicrobial Activity of Novel Synthetic Peptides Derived from Indolicidin and Ranalexin against Streptococcus pneumoniae. Jindal, Hassan Mahmood; Le, Cheng Foh; Mohd Yusof, Mohd Yasim; Velayuthan, Rukumani Devi; Lee, Vannajan Sanghiran; Zain, Sharifuddin Md; Isa, Diyana Mohd; Sekaran, Shamala Devi // PLoS ONE;Jun2015, Vol. 10 Issue 6, p1 

    Antimicrobial peptides (AMPs) represent promising alternatives to conventional antibiotics in order to defeat multidrug-resistant bacteria such as Streptococcus pneumoniae. In this study, thirteen antimicrobial peptides were designed based on two natural peptides indolicidin and ranalexin. Our...

  • Comparative antibacterial effects of moxifloxacin and levofloxacin on Streptococcus pneumoniae strains with defined mechanisms of resistance: impact of bacterial inoculum. Bowker, K. E.; Garvey, M. I.; Noel, A. R.; Tomaselli, S. G.; MacGowan, A. P. // Journal of Antimicrobial Chemotherapy (JAC);May2013, Vol. 68 Issue 5, p1130 

    Objectives We aim to further define the impact of the mechanism of fluoroquinolone resistance and inoculum load on the pharmacodynamic effects of levofloxacin and moxifloxacin on Streptococcus pneumoniae. Methods The antibacterial effects of and emergence of resistance (EoR) to moxifloxacin (400...

  • Macrolide Resistance from the Ribosome Perspective. Franceschi, F.; Kanyo, Z.; Sherer, E.C.; Sutcliffe, J. // Current Drug Targets - Infectious Disorders;Sep2004, Vol. 4 Issue 3, p177 

    Macrolides are important antibiotics used in treatment of respiratory tract infections in humans. Although some of these compounds have been in use for 50 years, it has not been until the last few years that their mechanism of action and the nature of ribosomal-based resistance could be more...

  • Clinical Pharmacokinetics of Telithromycin, the First Ketolide Antibacterial. Shi, Jun; Montay, Guy; Bhargava, Vijay O. // Clinical Pharmacokinetics;2005, Vol. 44 Issue 9, p915 

    Telithromycin is the first ketolide, which is a new class of antibacterial agents related to the macrolides that have structural modifications permitting dual binding to bacterial ribosomal RNA so that activity is retained against Streptococcus pneumoniae with...

  • The Clinical Relevance of Penicillin-Resistant Streptococcus pneumoniae: A New Perspective. File, Jr., Thomas M.; Tan, James S.; Boex, James R. // Clinical Infectious Diseases;3/15/2006, Vol. 42 Issue 6, p798 

    This article focuses on the clinical relevance of penicillin-resistant Streptococcus pneumoniae. Due to the emergence of several strains of Streptococcus pneumoniae that are resistant to penicillin and other antimicrobials, the approach to empirical therapy for community-acquired pneumonia has...

  • In This Issue.  // Clinical Infectious Diseases;10/1/2005, Vol. 41 Issue 7, pi 

    The article presents abstracts of the articles published in the October 2005 issue of the journal "Clinical Infectious Diseases." The article "Control of Penicillin-Nonsusceptible Streptococcus Pneumoniae (PNSP) Carriage" presents information about two intervention strategies to reduce...

  • Reduction of Antibiotic Use in the Community Reduces the Rate of Colonization with Penicillin G- Nonsusceptible Streptococcus pneumoniae. Guillemot, Didier; Varon, Emmanuelle; Bernède, Claire; Weber, Philippe; Henriet, Laurence; Simon, Sylvie; Laurent, Cécile; Lecoeur, Hervé; Carbon, Claude // Clinical Infectious Diseases;10/1/2005, Vol. 41 Issue 7, p930 

    Background. There is a lack of evidence documenting the impact of optimized antibiotic use on the rates of colonization with penicillin G-nonsusceptible Streptococcus pneumoniae (PNSP) in children. This study evaluates the effect of community-based intervention strategies on the prevalence of...

  • Limited Spread of Penicillin-Nonsusceptible Pneumococci, SkÃ¥ne County, Sweden. Melander, Eva; Hansson, Hans-Bertil; Mölstad, Sigvard; Persson, Kristina; Ringberg, Håkan // Emerging Infectious Diseases;Jun2004, Vol. 10 Issue 6, p1082 

    In response to increasing frequencies of penicillin-nonsusceptible pneumococci (PNSP), for which the MIC of penicillin was ≥0.12 mg/L, in Skåne County, southern Sweden, national recommendations were initiated in 1995 to limit the spread of pneumococci with high MICs (≥0.5 mg/L) of...

  • In Vivo Comparative Pharmacokinetics and Pharmacodynamics of Moxifloxacin and Levofloxacin in Human Neutrophils. Garraffo, Rodolphe; Lavrut, Thibaud; Durant, Jacques; Héripret, Laurence; Sérini, Marie-ange; Dunais, Brigitte; Dellamonica, Pierre // Clinical Drug Investigation;2005, Vol. 25 Issue 10, p643 

    Objective: Most of the newer fluoroquinolones are active against bacteria such as Streptococcus pneumoniae and Staphylococcus aureus, which are able to multiply inside polymorphonuclear leukocytes (PMNs). The aim of this study was to determine moxifloxacin and levofloxacin intracellular...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics