TITLE

The pharmacology and toxicology of 'ecstasy' (MDMA) and related drugs

AUTHOR(S)
Kalant, Harold
PUB. DATE
October 2001
SOURCE
CMAJ: Canadian Medical Association Journal;10/2/2001, Vol. 165 Issue 7, p917
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
"ECSTASY" (MDMA) AND RELATED DRUGS ARE AMPHETAMINE DERIVATIVES that also have some of the pharmacological properties of mescaline. They have become popular with participants in "raves," because they enhance energy, endurance, sociability and sexual arousal. This vogue among teenagers and young adults, together with the widespread belief that "ecstasy" is a safe drug, has led to a thriving illicit traffic in it. But these drugs also have serious toxic effects, both acute and chronic, that resemble those previously seen with other amphetamines and are caused by an excess of the same sympathomimetic actions for which the drugs are valued by the users. Neurotoxicity to the serotonergic system in the brain can also cause permanent physical and psychiatric problems. A detailed review of the literature has revealed over 87 "ecstasy"-related fatalities, caused by hyperpyrexia, rhabdomyolysis, intravascular coagulopathy, hepatic necrosis, cardiac arrhythmias, cerebrovascular accidents, and drug-related accidents or suicide. The toxic or even fatal dose range overlaps the range of recreational dosage. The available evidence does not yet permit an accurate assessment of the size of the problem presented by the use of these drugs.
ACCESSION #
5262980

 

Related Articles

  • The Perils of Ecstasy. de Seve, Karen // Current Health 2;Feb2006, Vol. 32 Issue 6, p26 

    The article deals with the dangers of using ecstasy drug.

  • PILL KICK: THE PURSUIT OF "ECSTASY" AT TECHNO-EVENTS. Hitzler, Ronald // Journal of Drug Issues;Spring2002, Vol. 32 Issue 2, p459 

    Skimming through current publications about �Techno and Drugs� without looking into the more detailed distinctions between them, one gets the impression that the increase in the use of ecstasy (MDMA) and the growth of the Techno-scene, especially in the 1990s, are highly correlated. In...

  • Persistent Psychosis and Medical Complications After a Single Ingestion of MDMA "Ecstasy"--A Case Report and Review of the Literature. Potash, Mordecai N.; Gordon, Kimberly A.; Conrad, Kristy L. // Psychiatry (1550-5952);Jul2009, Vol. 6 Issue 7, p40 

    We describe a case report of persistent psychosis and severe medical complications in a previously healthy, 19-year-old African-American man after a single ingestion of what was purported to be "Ecstasy." We detail the psychiatric symptoms and medical complications that resulted in several weeks...

  • ROLLING BEYOND RAVES: ECSTASY USE OUTSIDE THE RAVE SETTING. Boeri, Miriam Williams; Sterk, Claire E.; Elifson, Kirk W. // Journal of Drug Issues;Fall2004, Vol. 34 Issue 4, p831 

    In this paper, we explore settings of ecstasy use other than those that are part of the rave scene. Little is known about its use in other settings. Data from young adult (18-25 years old) active ecstasy users were collected using surveys (N = 158) and qualitative in-depth interviews (N = 66)....

  • Further signs of MDMA making a comeback on the 'ecstasy' market.  // Drugnet Europe;Oct-Dec2012, Issue 80, p2 

    The article informs that 3,4 methylenedioxy-N-methylamphetamine (MDMA), the widely known member of the ecstasy group of drugs, has shown signs of returning in the market due to new alternative chemicals used by manufacturers.

  • Pill purity at 10-year high.  // Mixmag;Feb2015, Issue 285, p24 

    The article offers information on the composition of the psychoactive drug ecstasy (MDMA) in pills consumed at rave parties and its effect.

  • Israel decriminalises ecstasy.  // Drugs & Alcohol Today;Nov2004, Vol. 4 Issue 3, p5 

    Reports on the decision of the Justice Ministry of Israel to decriminalize ecstasy pills users effective November 2004.

  • the lure of ecstasy. Cloud, John; Buia, Carole; Fulton, Greg; Park, Alice; Shannon, Elaine; Thompson, Dick // Time International (South Pacific Edition);6/5/2000, Issue 22, p46 

    Reports on the growing use of the drug ecstasy in the United States in 2000. Role of biochemist Alexander Shulgin in first writing about the drug and its effects in 1978; Description of how ecstasy effects the brain; Indications that ecstasy is less dangerous than cocaine or heroine and the...

  • Level of use of 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) in humans correlates with EEG power and coherence. Dafters, R. I.; Duffy, Frances; O'Donnell, Patrick J.; Bouquet, Caroline // Psychopharmacology;1999, Vol. 145 Issue 1, p82 

    Abstract Rationale: Despite animal studies implicating 3,4-methylenedioxymethamphetamine (MDMA or Ecstasy) in serotonergic neurotoxicity, there is little direct evidence of changes in neural function in humans who use MDMA as a recreational drug. Objective: The present study investigated whether...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics