TITLE

Mass spectral imaging and profiling of neuropeptides at the organ and cellular domains

AUTHOR(S)
Ruibing Chen; Lingjun Li
PUB. DATE
August 2010
SOURCE
Analytical & Bioanalytical Chemistry;Aug2010, Vol. 397 Issue 8, p3185
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry (MS) is a rapid and sensitive analytical method that is well suited for determining molecular weights of peptides and proteins from complex samples. MALDI-MS can be used to profile the peptides and proteins from single-cell and small tissue samples without the need for extensive sample preparation. Furthermore, the recently developed MALDI imaging technique enables mapping of the spatial distribution of signaling molecules in tissue samples. Several examples of signaling molecule analysis at the single-cell and single-organ levels using MALDI-MS technology are highlighted followed by an outlook of future directions. [Figure not available: see fulltext.]
ACCESSION #
52532535

 

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