TITLE

Chapter 16: Synthesis of New Reactivators of Cholinesterase

AUTHOR(S)
Petrova, Iskra; Samnaliev, Ivan; Dishovsky, Christophor
PUB. DATE
January 2010
SOURCE
Journal of Medical Chemical, Biological & Radiological Defense;2010, Vol. 8, p115
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Irrespective of the fact that the main mechanism of toxicity of the nerve agents (tabun, sarin, soman, cyclosarin, VX) - inhibition of acetylcholinesterse (AChE) in peripheral and central nervous systems is very well known there are some unresolved problems related to the antidote treatment of this type of poisoning. One of the most important question is that many studies have shown that none of the currently available reactivators of cholinesterase, such as 2-PAM, obidoxime (toxogonin), HI-6 and trimedoxime is able to reactivate AChE inhibited by all compounds belonging to the nerve agents. That is way a lot of new cholinesterase reactvators with different chemical structure have been synthesized and tested by using in vitro or in vivo methods for their antidote activity. In our study we describe the synthesis of some new reacrivators of ChE and the results obtained for their therapeutic efficacy in rats poisoned with soman and tabun. Our date have shown that two of compounds - BT-05 and BT-07 4M combined with atropine demonstrated very good effectiveness against tabun.
ACCESSION #
52490799

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics