TITLE

Fasting Upregulates PPARα Target Genes in Brain and Influences Pituitary Hormone Expression in a PPARα Dependent Manner

AUTHOR(S)
König, Bettina; Rauer, Christine; Rosenbaum, Susann; Brandsch, Corinna; Eder, Klaus; Stangl, Gabriele I.
PUB. DATE
January 2009
SOURCE
PPAR Research;2009, Special section p1
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
PPARα is a lipid-activable transcription factor that mediates the adaptive response to fasting. Recent data indicate an important role of brain PPARα in physiological functions. However, it has not yet been shown whether PPARα in brain can be activated in the fasting state. Here we demonstrate that fasting of rats increased mRNA concentrations of typical PPARα target genes implicated in β-oxidation of fatty acids (acyl-CoA oxidase, carnitine palmitoyltransferase-1, medium chain acyl-CoA dehydrogenase) and ketogenesis (mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase) in pituitary gland and partially also in frontal cortex and diencephalon compared to nonfasted animals. These data strongly indicate that fasting activates PPARα in brain and pituitary gland. Furthermore, pituitary prolactin and luteinizing hormone-β mRNA concentrations were increased upon fasting in wild-type mice but not in mice lacking PPAR α. For proopiomelanocortin and thyrotropin-β, genotype-specific differences in pituitary mRNA concentrations were observed. Thus, PPARα seems to be involved in transcriptional regulation of pituitary hormones.
ACCESSION #
52485742

 

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics