TITLE

Long-Term Metformin Use Is Associated With Decreased Risk of Breast Cancer

AUTHOR(S)
Bodmer, Michael; Meier, Christian; Krähenbühl, Stephan; Jick, Susan S.; Meier, Christoph R.
PUB. DATE
June 2010
SOURCE
Diabetes Care;Jun2010, Vol. 33 Issue 6, p1304
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
OBJECTIVE -- To evaluate whether use of oral hypoglycemic agents is associated with an altered breast cancer risk in women. RESEARCH DESIGN AND METHODS-- Using the U.K.-based General Practice Research Database, we conducted a nested case-control analysis among 22,621 female users of oral antidiabetes drugs with type 2 diabetes. We evaluated whether they had an altered risk of breast cancer in relation to use of various types of oral hypoglycemic agents. Case and control patients with a recorded diagnosis of type 2 diabetes were matched on age, calendar time, and general practice, and the multivariate conditional logistic regression analyses were further adjusted for use of oral antidiabetes drugs, insulin, estrogens, smoking BMI, diabetes duration, and HbA1c (A1C). RESULTS-- We identified 305 case patients with a recorded incident diagnosis of breast cancer. The mean ± SD age was 67.5 ± 10.5 years at the time of the cancer diagnosis. Long-term use of ≥40 prescriptions (>5 years) of metformin, based on 17 exposed case patients and 120 exposed control patients, was associated with an adjusted odds ratio of 0.44 (95% CI 0.24-0.82) for developing breast cancer compared with no use of metformin. Neither short-term metformin use nor use of sulfonylureas or other antidiabetes drugs was associated with a materially altered risk for breast cancer. CONCLUSIONS-- A decreased risk of breast cancer was observed in female patients with type 2 diabetes using metformin on a long-term basis.
ACCESSION #
52482716

 

Related Articles

  • Prolonged Nocturnal Hypoglycemia Is Common During 12 Months of Continuous Glucose Monitoring in Children and Adults With Type 1 Diabetes.  // Diabetes Care;May2010, Vol. 33 Issue 5, p1004 

    OBJECTIVE -- To characterize the amount of nocturnal hypoglycemia and evaluate factors associated with nocturnal hypoglycemia assessed with continuous glucose monitoring (CGM) in adults and children with type 1 diabetes who participated in the Juvenile Diabetes Research Foundation CGM...

  • Prevention of Nocturnal Hypoglycemia Using Predictive Alarm Algorithms and Insulin Pump Suspension. Buckingham, Bruce; Chase, H. Peter; Dassau, Eyal; Cobry, Erin; Clinton, Paula; Gage, Victoria; Caswell, Kimberly; Wilkinson, John; Cameron, Fraser; Lee, Hyunjin; Bequette, B. Wayne; Doyle III, Francis J. // Diabetes Care;May2010, Vol. 33 Issue 5, p1013 

    OBJECTIVE -- The aim of this study was to develop a partial closed-loop system to safely prevent nocturnal hypoglycemia by suspending insulin delivery when hypoglycemia is predicted in type 1 diabetes. RESEARCH DESIGN AND METHODS-- Forty subjects with type 1 diabetes (age range 12-39 years)...

  • Minerva.  // BMJ: British Medical Journal (International Edition);10/16/93, Vol. 307 Issue 6910, p1016 

    Reports developments related to medicine as of October 16, 1993. Development of a gene for the amyloid precursor protein into mice; Reduction in complications of diabetes in patients given intensive insulin treatment; Risk of breast cancer in women with relatives with the disease.

  • Left prostrate by the prostate. Sweet, Melissa // Bulletin with Newsweek;02/15/2000, Vol. 118 Issue 6211, p57 

    Presents health-related news items, compiled in the week of February 15, 2000. Impotence and incontinence caused by prostate surgery; Increase in breast cancer following hormone replacement therapy; Possibility that cognitive impairment may be the potential long-term outcome of diabetes.

  • Prescribing Pattern of Antidiabetic Drugs in Indore City Hospital. VENGURLEKAR, SUDHA; SHUKLA, PRERNA; PATIDAR, P.; BAFNA, R.; JAIN, S. // Indian Journal of Pharmaceutical Sciences;2008, Vol. 70 Issue 5, p637 

    Diabetes mellitus is a metabolic disorder characterized by hyperglycemia, glycosuria, and sometimes ketonemia. The present study was carried out to assess prescribing practice and general trend of diabetes among patients at the Bombay Hospital, Indore. Prescriptions and complete records of...

  • Antidiabetic activity of fruit pulp of Feronia elephantum Corr. Mishra, Anurag; Garg, Ganesh Prasad // Pharmacognosy Journal;Feb2011, Vol. 3 Issue 20, p27 

    Feronia elephantum Corr. Commonly known as Bela, Billin, Kath, is a commonly known herb in Indian system of medicine to treat various disorders including diabetes mellitus without any scientific evidences. Therefore this study was designed to investigate in vivo hypoglycemic and antidiabetic...

  • Management - Complications and Comorbidities.  // Current Medical Literature: Diabetes;2011, Vol. 28 Issue 1, p31 

    This article offers commentaries on several papers on the management of complications of diabetes. The first paper studies the fear of hypoglycemia in adults with diabetes. The second paper analyzes the effect of baseline renal function on the efficacy and safety of aliskiren. Another paper...

  • Motor Vehicle Crashes in Diabetic Patients with Tight Glycemic Control: A Population-based Case Control Analysis. Redelmeier, Donald A.; Kenshole, Anne B.; Ray, Joel G. // PLoS Medicine;Dec2009, Vol. 6 Issue 12, p1 

    Background Complications from diabetes mellitus can compromise a driver's ability to safely operate a motor vehicle, yet little is known about whether euglycemia predicts normal driving risks among adults with diabetes. We studied the association between glycosylated hemoglobin (HbA1c) and the...

  • Illuminating the Diabetes–Cancer Link. Brower, Vicki // JNCI: Journal of the National Cancer Institute;7/18/2012, Vol. 104 Issue 14, p1048 

    The article discusses the findings of a research on the link between diabetes and cancer. In a study delivered at the San Antonio Breast Cancer Symposium held in Texas in December 2011, women with diabetes above 60-years old were found to have higher risk of breast cancer than nondiabetics in...

Share

Read the Article

Courtesy of THE LIBRARY OF VIRGINIA

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics