Relja, Maja
June 2009
Rad Hrvatske Akademije Znanosti i Umjetnosti. Medicinske Znanost;Jun2009, Vol. 501 Issue 33, p123
Academic Journal
Since its development for clinical use in 1980s botulinum toxin, the most potent biological toxin known to man has become a useful drug in various field of medicine. It was initially used to treat neurological disorders characterized by excessive muscle contractions. Since many patients report alleviation of pain before the muscle relaxing effect of botulinum toxin type-A has started, a direct analgesic action of Botulinum toxin has been discussed. There have been a number of recent investigations concerning the efficacy of botulinum toxin type-A applications for treatment of headache and chronic pain. Most of the known effect of botulinum toxin has been attributed to its ability to inhibit the release of acetylcholine from cholinergic nerve terminal. However, this effect alone does not explain the apparent antinociceptive effect of botulinum toxin. Other peripheral and central neurogenic effect should be considered. Current data suggest that Botulinum toxin is safe and effective in headache and pain treatment if used in specialist centres by experienced doctors.


Related Articles

  • Promise seen for Botox in studies focusing on headache treatment. PEDERSEN, AMANDA // Biomedical Business & Technology;Oct2008, Vol. 31 Issue 10, p35 

    The article talks about the pursuit by Allergan of botulinum toxin type A or Botox therapy to treat headaches and migraines. Allergan said it has completed a top-line analysis of its two Phase III trials exploring the use of Botox for the prophylactic treatment of headache in adults suffering...

  • Clinical Profile of Botulinum Toxin A in Patients with Chronic Headaches and Cervical Dystonia: A Prospective, Open-Label, Longitudinal Study Conducted in a Naturalistic Clinical Practice Setting. Dowson, Andrew J; Kilminster, Shaun G; Salt, Rebecca // Drugs in R&D;2008, Vol. 9 Issue 3, p147 

    BACKGROUND AND OBJECTIVES: Some evidence for the efficacy of botulinum toxin A as a preventive treatment for chronic primary headaches has been reported in randomized, controlled clinical studies. This study investigated the clinical profile of botulinum toxin A in a naturalistic clinical...

  • Pain management in the pharmacy: headaches. Whittaker, C. // South African Pharmacist's Assistant;Autumn2011, Vol. 11 Issue 1, p14 

    The article focuses on the management of headache. It notes that headache is a common medical ailment among patients who ask for medications in the pharmacy, urging pharmacist's assistants to educate patients on how to safely use over-the-counter (OTC) drugs. It mentions that 90 percent of...

  • TENSION HEADACHE. Silver, Nicholas // Pulse;2/11/2009, Vol. 69 Issue 4, p32 

    The article discusses the symptoms, prevention and treatment for tension-type headache (TTH). TTH is characterized by pain in bilateral location with mild or moderate intensity, pressure or constriction that is patchy and pain that may last for hours or days. Possible drugs for prevention and...

  • Head case. van Ogtrop, Kristin // Vogue;Oct99, Vol. 189 Issue 10, p286 

    Focuses on the treatment of tension-type headaches. Increase in headache-related research and societies; Difference between tension-type headaches and migraine; Causes of tension-type headaches; Cure for severe headaches; Drawback to the overuse of pain medications; Medications to relieve...

  • Mehanizam djelovanja i terapija botulinum toksinom. Alajbegović, Azra; Alajbegović, Salem; HalimaResić // Medical Archives / Medicinski Arhiv;2008, p53 

    Botulinum neurotoxin (BoNT) is produced by Clostridium botulinum as a complex of proteins containing the neurotoxin itself and other nontoxic proteins. Activation of the neurotoxin occurs upon proteolytic cleavage into the heavy and light chains. This di-chain moiety is essential for neurotoxin...

  • Headache and botulinum toxin. Porta, Mauro; Camerlingo, Massimo // Journal of Headache & Pain;Sep2005, Vol. 6 Issue 4, p325 

    The authors discuss clinical and international experience about botulinum toxins (BTX types A and B) in headache treatment. Data from literature suggest good results for the treatment of tensiontype headache, migraine and chronic tension–type headache. In the present paper mechanisms of...

  • head hurting? Warren, Emily Kate // Cosmo Girl;Nov2007, Vol. 9 Issue 9, p71 

    The article offers information on the causes of and treatment for the most common types of headaches. A migraine is caused by dehydration or a drop in hormone levels when women have their menstrual period. A sinus headache is usually accompanied by green mucus and a fever. Giving one's self a...

  • AÄŸrılı Durumlarda Botulinum Toksini. ERTAŞ, Mustafa // Archives of Neuropsychiatry / Noropsikiatri Arsivi;Dec2010, Vol. 47 Issue 4, p52 

    After the first observations that botulinum toxin used for cosmetic aims also relieved coexisting migraine, its effectiveness have been studied in migraine and tension-type headache without reaching a clear conclusion because of controversial results. Further studies revealed stronger...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics