TITLE

Evaluation of Phytochemical standards and In Vitro Antioxidant Activity of tannins rich fraction of Stem Bark of Bridelia retusa (Li)

AUTHOR(S)
Tatiya, A. U.; Saluja, A. K.
PUB. DATE
January 2010
SOURCE
International Journal of PharmTech Research;Jan-Mar2010, Vol. 2 Issue 1, p649
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Bridelia retusa syn:Bridelia airy shawii Li. bark is known to have various medicinal properties. Plants containing polyphenols have been reported to possess strong antioxidant properties. The bark of Bridelia retusa was screened for estimation of phytochemical standards like: phenolic, flavonoid, tannins, carbohydrates and mucilage content. In addition to its acetone fraction (ACE) i.e. tannins rich fraction, are also subjected to in vitro antioxidant activity using standard procedures. Results of Phytochemical standards analysis of B.retusa revealed the presence of bioactive components comprising Phenolics (2.92-3 g of GAE/100 g of dry sample), total tannins (33-43 % w/w as tannic acid equivalence), proanthocyanidin content (2.98-4 % w/w as catechin equivalent), ellagic acid (0.135 % w/w), mucilage (3-4 % w/w), flavonoids (257 mg of Rutin equivalence/100 g dry plant) and carbohydrates. (7 - 7.1g /100g of plant). The ACE exhibited IC50 values of 47.20, 110.76, 48.81 44.15 and 50.42 μg/ml, respectively in DPPH, ALP, hydroxyl, hydrogen peroxide and nitric oxide radical inhibition assays while ACE had effective reducing power. These values were compared with ascorbic acid and BHA used as internal standard. These results suggest strong antioxidant potentials of the ACE of Bridelia retusa. These bioactive compounds may be responsible for antioxidant properties of B.retusa that form the basis of their use in herbal medicine in India,
ACCESSION #
52445593

 

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