TITLE

Changes in Lipid Profiles in Two Groups of HIV-1 Infected Patients in Cameroon on Two Treatment Regimens with Either Efavirenz or Nevirapine, in Association with Reverse Transcriptase Inhibitors

AUTHOR(S)
Nguemaïm, N. F.; Mbuagbaw, J.; Nkoa, T.; Této, G.; Njitchouang, G. R.; Pouomogne, D. J.; Samé-Ekobo, A.; Asonganyi, T.
PUB. DATE
March 2010
SOURCE
Journal of Medical Sciences;2010, Vol. 10 Issue 2, p25
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The aim of this study was to determine the effect of two antiretroviral therapy regimens on lipid profiles. Patients were allocated to two treatment regimens: Nevirapine (NVP) + Stavudine (d4T) + Lamivudine (3TC) (n = 197) or Efavirenz (EFV) + Stavudine (d4T) + Lamivudine (3TC) (n = 181). Serum was prepared from blood samples collected before the start of treatment (Month 0) and at 24 months. Lipids and lipoproteins were measured using colorimetric enzyme assays or by calculation. Overall, there was an increase in all lipid parameters in patients on both treatment regimens at 24 months, although there were individual differences with respect to each lipid parameter that affected the atherogenicity indices for both regimens. Increase of high density lipoprotein cholesterol (HDLC) (42.82%) was significantly larger in patients on the NVP than on EFV (24.03%) (p<0.001), as opposed to Total Cholesterol (TC), triglycerides (TG) And Low Density Lipoprotein Cholesterol (LDLC) that were significantly lower in patient on NVP than on EFV; TG, Very Low Density Lipoproteins (VLDL) and LDLC increased in both regimens. These changes were not much affected by changes in viral load and CD4 cell levels. The changes in the atherogenicity indices showed that the regimen with NVP seems to have less risk of coronary heart disease compared to EFV.
ACCESSION #
52416228

 

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