TITLE

FORMULATION AND EVALUATION OF CETIRIZINE DIHYDROCHLORIDE ORODISPERSIBLE TABLET

AUTHOR(S)
Subramanian, S.; Sankar, V.; Manakadan, Asha Asokan; Ismail, Sareena; Andhuvan, G.
PUB. DATE
April 2010
SOURCE
Pakistan Journal of Pharmaceutical Sciences;Apr2010, Vol. 23 Issue 2, p232
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Cetirizine orodispersible tablets were prepared to achieve quick onset of action and for maximum bioavailability. Tablets were prepared using cetirizine along with camphor and mannitol in the proportion of 1:1:1, 1:1:3, and 1:1:6. The flow property of granules was found to be good for the formulation CZ2 (1:1:3). The hardness and friability of all the formulations were found to be within the standard limit for orodispersible tablets. Disintegration time was found to be rapid in formulation CZ2 (1:1:3).The in vitro dissolution time was found to be 100% in 11 minutes for the formulation CZ2 (1:1:3).
ACCESSION #
52292258

 

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