TITLE

THYMOQUINONE SUPPLEMENTATION AMELIORATES ACUTE ENDOTOXEMIA-INDUCED LIVER DYSFUNCTION IN RATS

AUTHOR(S)
Helal, Gouda K.
PUB. DATE
April 2010
SOURCE
Pakistan Journal of Pharmaceutical Sciences;Apr2010, Vol. 23 Issue 2, p131
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Endotoxemia caused by lipopolysaccharide (LPS) produced an inflammatory condition contributing to multiple organ failure. This study was carried out to investigate the effects of thymoquinone (TQ), the main constituent of Nigella sativa seeds, against LPS-induced hepatotoxicity. The obtained data revealed that LPS markedly depleted liver reduced glutathione (GSH) and significantly increased the level of malondialdehyde (MDA) and the activity of caspase-3 enzyme in the liver. Serum tumour necrosis factor-alpha (TNF-α) and bilirubin levels and the activities of alkaline phosphatase (ALP) and gamma-glutamyl transferase (γ-GT) enzymes were markedly increased in LPS-treated rats. TQ supplementation resulted in normalization of liver GSH and decreases in the levels of MDA and caspase-3 activity in the liver with reduction of serum TNF-α, serum total bilirubin and the actvities of ALP and γ-GTenzymes. Histopathological examination revealed that TQ administration improved LPS-induced pathological abnormalities in liver tissues. The present study conclude that TQ reduced acute endoxemia-induced liver dysfunction at least in part by its anti-inflammatory, antiapoptotic and antioxidant activities.
ACCESSION #
52292241

 

Related Articles

  • Low dose endotoxin priming is accountable for coagulation abnormalities and organ damage observed in the Shwartzman reaction. A comparison between a single-dose endotoxemia model and a double-hit endotoxin-induced Shwartzman reaction. Slofstra, Sjoukje H.; Cate, Hugo Ten; Spek, C. Arnold // Thrombosis Journal;2006, Vol. 4, p13 

    The clinical response of sepsis to a systemic inflammatory infection may be complicated by disseminated intravascular coagulation or DIC. In order to experimentally study the syndrome of DIC, we aimed for a severe sepsis model complicated by disseminated coagulation. Most - simplified-...

  • Antioxidant Effects of Nigella Sativa in the Treatment of Experimentally Induced Rhinosinusitis. Yoruk, Ozgur; Gur, Fatma Ozabacigil; Uyanik, Hamidullah; Yasar, Murat; Mutlu, Vahit; Altas, Enver; Baysal, Elif; Taysi, Seyithan // Macedonian Journal of Medical Sciences;6/1/2010, Vol. 3 Issue 2, p132 

    Aim. The objective of this study was to investigate the effect of Nigella sativa (NS) in experimental bacterial rhinosinusitis. Material and Methods. Bacterial rhinosinusitis was induced with Staphylococcus aureus. Rabbits were divided into control, NS 50, NS 100 and NS 200 mg/kg/d groups. NS...

  • LPS pretreatment ameliorates multiple organ injuries and improves survival in a murine model of polymicrobial sepsis. Shi, Dong-Wei; Zhang, Jing; Jiang, Hong-Ni; Tong, Chao-Yang; Gu, Guo-Rong; Ji, Yuan; Summah, Hanssa; Qu, Jie-Ming // Inflammation Research;Sep2011, Vol. 60 Issue 9, p841 

    Objective: The endotoxin tolerance phenotype is characterized with decreased inflammation and increased phagocytosis. We hypothesized that endotoxin tolerance would provide protective effects on experimental sepsis with multiple organ injuries induced by cecal ligation and puncture (CLP)....

  • BREATH BETTER.  // American Herb Association Quarterly Newsletter;Fal2011, Vol. 26 Issue 4, pp13 

    The article discusses research being done on black cumin which references the study on its antiasthmatic effect and the review of 18 Iranian herbs.

  • Etanercept protects remote organ damage in a rat model of thermal injury. Şehirli, Özer; Ünlü, Burcu; Çetinel, Şule; Tetik, Şermin; Şener, Emre; Şener, Göksel // Marmara Pharmaceutical Journal;Sep2011, Vol. 15 Issue 3, p118 

    Thermal injury may lead to systemic inflammatory response, and multiple organ failure. This study was designed to determine the possible protective effect of etanercept treatment against oxidative damage in the lung tissue induced by burn injury. Under ether anaesthesia, the shaved dorsum of...

  • Circulaci�n espl�cnica y choque s�ptico. Un acercamiento fisiopatol�gico. Mote, Jes�s Duarte; Salvador D�az Meza; Castro, V�ctor Lee Eng; D�az, Ver�nica Vel�squez; L�pez, Marco Antonio Ord��ez // Medicina Interna de Mexico;jul/ago2007, Vol. 23 Issue 4, p330 

    Despite major improvements in patients' management with severe sepsis, many of them will develop multiple organ failure and will subsequently die. Infection, trauma, burns, surgery and cardiac compromise may increase the metabolic rate by 20%, resulting in higher oxygen utilization. Injury to...

  • N-Acetylcysteine Ameliorates Lipopolysaccharide-Induced Organ Damage in Conscious Rats. Bang Gee Hsu; Fwu Lin Yang; Ru Ping Lee; Tai Chu Peng; Horng Jyh Harn; Hsing I. Chen // Journal of Biomedical Science;Mar/Apr2004, Vol. 11 Issue 2, p152 

    Lipopolysaccharide is strongly associated with septic shock, leading to multiple organ failure. It can activate monocytes and macrophages to release proinflammatory mediators such as tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and nitric oxide (NO). The present...

  • Physiological and Chemical Indicators for Early and Late Stages of Sepsis in Conscious Rats. Ru Ping Lee; Wang, David; Nien Tsung Lin, David; Chen, Hsing I. // Journal of Biomedical Science;2002, Vol. 9 Issue 6, p613 

    Endotoxin shock is a major cause of death in patients with septicemia. Endotoxin induces nitric oxide (NO) production and causes tissue damage. In addition, the release of oxygen free radicals has also been observed in endotoxin shock and was found to be responsible for the occurrence of...

  • Clinical Study on Therapy of Clearing Hallow Viscera in Treating Critical Patients with Gastro-enteric Function Disorder. Yang Sheng-lan; Li Dao-ben // Chinese Journal of Integrative Medicine;Jun2006, Vol. 12 Issue 2, p122 

    Objective: To explore the clinical affect of therapy of clearing hallow viscera in treating critical patients with gastro-enteric function disorder (GEFD). Methods: Retrospective analysis was carried out on 96 critical patients. They were 48 patients in the treated group treated with Dachengqi...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics