TITLE

Genetic Evidence Supports a Role for the Yeast CCR4-NOT Complex in Transcriptional Elongation

AUTHOR(S)
Denis, Clyde L.; Yueh-Chin Chiang; Yajun Cui; Junji Chen
PUB. DATE
June 2001
SOURCE
Genetics;Jun2001, Vol. 158 Issue 2, p627
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Examines the role of yeast CCR4-NOT complex in the regulation of gene expression. Genetic evidence for CCR4 involvement in transcriptional elongation; Synthetic interaction between ccr4 and rpb2, dst1 and spt16 defects; Allele-specific interactions between ccr4 and rpb1 allele.
ACCESSION #
5226300

 

Related Articles

  • A Probabilistic Approach to Study Yeast's Gene Regulatory Network. Pinto, F. R. // Journal of Computer Science & Systems Biology;Jan-Feb2009, Vol. 2 Issue 1, p44 

    Using only the transcription network structure information, a probabilistic model was developed that computes the probabilities with which a pair of genes responds simultaneously (SR) or differentially (DR) to a random network perturbation. Study of yeast's transcription regulatory network in...

  • Mechanisms of ethanol tolerance in Saccharomyces cerevisiae. Ma, Menggen; Liu, Z. // Applied Microbiology & Biotechnology;Jul2010, Vol. 87 Issue 3, p829 

    Saccharomyces cerevisiae is a superb ethanol producer, yet is also sensitive to higher ethanol concentrations especially under high gravity or very high gravity fermentation conditions. Ethanol tolerance is associated with interplay of complex networks at the genome level. Although significant...

  • Gene regulation: A reason for reading nonsense. Schmitt, Sabine; Paro, Renato // Nature;6/3/2004, Vol. 429 Issue 6991, p510 

    The process of transcribing DNA can itself regulate gene expression in yeast: In the case concerned it is the very act of reading the DNA, not the message produced, that carries out the regulatory job. Researcher J.A. Martens and colleagues show method by which RNA polymerase II transcribes DNA...

  • Rewiring yeast osmostress signalling through the MAPK network reveals essential and non-essential roles of Hog1 in osmoadaptation. Babazadeh, Roja; Takako Furukawa; Stefan Hohmann; Kentaro Furukawa // Scientific Reports;4/18/2014, p1 

    Mitogen-activated protein kinases (MAPKs) have a number of targets which they regulate at transcriptional and post-translational levels to mediate specific responses. The yeast Hog1 MAPK is essential for cell survival under hyperosmotic conditions and it plays multiple roles in gene expression,...

  • Genomic Insights into the Different Layers of Gene Regulation in Yeast. Pérez-Ortín, José E.; Medina, Daniel A.; Jordán-Pla, Antonio // Genetics Research International;2011, p1 

    The model organism Saccharomyces cerevisiae has allowed the development of new functional genomics techniques devoted to the study of transcription in all its stages. With these techniques, it has been possible to find interesting new mechanisms to control gene expression that act at different...

  • The Candida albicans-Specific Gene EED1 Encodes a Key Regulator of Hyphal Extension. Martin, Ronny; Moran, Gary P.; Jacobsen, Ilse D.; Heyken, Antje; Domey, Jenny; Sullivan, Derek J.; Kurzai, Oliver; Hube, Bernhard // PLoS ONE;2011, Vol. 6 Issue 4, p1 

    The extension of germ tubes into elongated hyphae by Candida albicans is essential for damage of host cells. The C. albicans-specific gene EED1 plays a crucial role in this extension and maintenance of filamentous growth. eed1D cells failed to extend germ tubes into long filaments and switched...

  • Loss of the Yeast SR Protein Npl3 Alters Gene Expression Due to Transcription Readthrough. Holmes, Rebecca K.; Tuck, Alex C.; Zhu, Chenchen; Dunn-Davies, Hywel R.; Kudla, Grzegorz; Clauder-Munster, Sandra; Granneman, Sander; Steinmetz, Lars M.; Guthrie, Christine; Tollervey, David // PLoS Genetics;12/22/2015, Vol. 11 Issue 12, p1 

    Yeast Npl3 is a highly abundant, nuclear-cytoplasmic shuttling, RNA-binding protein, related to metazoan SR proteins. Reported functions of Npl3 include transcription elongation, splicing and RNA 3’ end processing. We used UV crosslinking and analysis of cDNA (CRAC) to map precise RNA...

  • Rewiring the circuitry. Campbell, Nick // Nature Reviews Genetics;Jan2004, Vol. 5 Issue 1, p7 

    Reports on research done by Annie Tsong that compares the transcriptional circuits that regulate mating type in yeast species. Significance of transcriptional circuitry in the regulation of mating; Adaptation of regulatory-circuit elements as a viable means of adapting to new environments.

  • Identifying Neighborhoods of Coordinated Gene Expression and Metabolite Profiles. Hancock, Timothy; Wicker, Nicolas; Takigawa, Ichigaku; Mamitsuka, Hiroshi // PLoS ONE;Feb2012, Vol. 7 Issue 2, p1 

    In this paper we investigate how metabolic network structure affects any coordination between transcript and metabolite profiles. To achieve this goal we conduct two complementary analyses focused on the metabolic response to stress. First, we investigate the general size of any relationship...

Share

Other Topics