2D and 3D Ultrasound Prediction of Homozygous α0-Thalassemia

Leung, K. Y.; Cheong, K. B.; Tang, M. H. Y.
April 2010
Donald School Journal of Ultrasound in Obstetrics & Gynecology;Apr-Jun2010, Vol. 4 Issue 2, p123
Academic Journal
Conventionally, prenatal diagnosis is achieved by an invasive procedure followed by DNA analysis or hematological study. With experienced hand and a good ultrasound machine, a noninvasive approach consisting of serial two-dimensional ultrasound examinations of cardiothoracic ratio and placenta thickness can effectively reduce the need for invasive testing in the majority of unaffected pregnancies. Although middle cerebral artery peak systolic velocity (MCAPSV) is a well-established sonographic marker for predicting fetal anemia due to Rhesus isoimmunization, it is not clear whether MCAPSV is useful in the prediction of affected pregnancies. Preliminary studies have been performed to investigate the use of 3D ultrasound in the prediction of pregnancies affected by homozygous α0-thalassemia. It seems that 3D is not superior to 2D ultrasound prediction of affected pregnancies.


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