TITLE

Characterization of sensing capability of optofluidic ring resonator biosensors

AUTHOR(S)
Hao Li; Xudong Fan
PUB. DATE
July 2010
SOURCE
Applied Physics Letters;7/5/2010, Vol. 97 Issue 1, p011105
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
The sensing capability of the capillary-based optofluidic ring resonator in bulk refractive index (RI) detection and label-free small molecule detection is investigated. In bulk RI detection, a sensitivity of 570 nm/refractive index units (RIU) is achieved with a Q-factor of 1.2×105. A change of 2.8×10-7 RIU is observed with the noise equivalent detection limit (NEDL) of 3.8×10-8 RIU. In small molecule detection, 10 nM biotin is detected with surface mass density of 1.6 pg/mm2. The NEDL is approximately 0.14 pg/mm2. These results set the benchmark for ring resonator sensing performance and compare very favorably with those obtained with other label-free optical sensors.
ACCESSION #
52060136

 

Related Articles

  • Reflection-mode sensing using optical microresonators. Koch, Barry; Yi, Yasha; Zhang, Jun-Ying; Znameroski, Stephen; Smith, Terry // Applied Physics Letters;11/16/2009, Vol. 95 Issue 20, p201111 

    The authors present an approach for applying optical microring resonators to sensing. The approach relies on the interaction of the resonator with a nanoparticle taggant, which can induce coupling between forward and backward propagating traveling-wave resonant modes of the device. In the...

  • Refractometric sensors based on microsphere resonators. Hanumegowda, Niranjan M.; Stica, Caleb J.; Patel, Bijal C.; White, Ian; Xudong Fan // Applied Physics Letters;11/14/2005, Vol. 87 Issue 20, p201107 

    We have developed a highly sensitive refractometric sensor based on fused silica microsphere resonators. The spectral position of the whispering gallery mode (WGM) of a sphere shifts in response to the refractive index change in the surrounding medium. The strong light-matter interaction due to...

  • Localized optical resonances in low refractive index rolled-up microtube cavity for liquid-core optofluidic detection. Bolaños Quiñones, Vladimir A.; Ma, Libo; Li, Shilong; Jorgensen, Matthew; Kiravittaya, Suwit; Schmidt, Oliver G. // Applied Physics Letters;10/8/2012, Vol. 101 Issue 15, p151107 

    Spatially localized high order axial resonant modes are observed in a SiO/SiO2-based microtube cavity rolled-up from a prestrained nanomembrane. A diameter variation of the tube structure is revealed which provides localized axial confinement. Optofluidic detection is demonstrated by filling the...

  • High-Sensitivity Refractive Index Sensor Based on D-Shaped Photonic Crystal Fiber with Rectangular Lattice and Nanoscale Gold Film. An, Guowen; Li, Shuguang; Qin, Wei; Zhang, Wan; Fan, Zhenkai; Bao, Yajie // Plasmonics;Dec2014, Vol. 9 Issue 6, p1355 

    We propose and investigate a D-shaped photonic fiber refractive index sensor with rectangular lattice based on surface plasmon resonance. In such sensor, the nanoscale gold metal film is deposited on the flat surface where it is side polished. Numerical results show that the average sensitivity...

  • Optical Sensors Based on Whispering Gallery Modes in Fluorescent Microbeads: Size Dependence and Influence of Substrate. Francois, Alexandre; Michael Himmelhaus // Sensors (14248220);2009, Vol. 9 Issue 9, p6836 

    Whispering gallery modes in surface-fixated fluorescent polystyrene microbeads are studied in view of their capability of sensing changes in the refractive index of the beads' environment by exposing them to water/glycerol mixtures of varying composition. The mode positions are analyzed by...

  • Toward Automatic Label-Free Whispering Gallery Modes Biodetection with a Quantum Dot-Coated Microsphere Population. Charlebois, M.; Paquet, A.; Verret, L. S.; Boissinot, K.; Boissinot, M.; Bergeron, M. G.; Allen, C. Nì // Nanoscale Research Letters;Mar2010, Vol. 5 Issue 3, p524 

    We explore a new calibration-free approach to biodetection based on whispering gallery modes (WGMs) without a reference measure and relative shifts. Thus, the requirement to keep track of the sensor position is removed, and a freely moving population of fluorophore-doped polystyrene microspheres...

  • Label Free Detection of CD4+ and CD8+ T Cells Using the Optofluidic Ring Resonator. Gohring, John T.; Xudong Fan // Sensors (14248220);2010, Vol. 10 Issue 6, p5798 

    We have demonstrated label free detection of CD4+ and CD8+ T-Lymphocyte whole cells and CD4+ T-Lymphocyte cell lysis using the optofluidic ring resonator (OFRR) sensor. The OFRR sensing platform incorporates microfluidics and photonics in a setup that utilizes small sample volume and achieves a...

  • Integrated silicon optofluidic ring resonator. Testa, Genni; Huang, Yujian; Sarro, Pasqualina M.; Zeni, Luigi; Bernini, Romeo // Applied Physics Letters;9/27/2010, Vol. 97 Issue 13, p131110 

    The feasibility of an integrated silicon optofluidic ring resonator is demonstrated. Liquid core antiresonant reflecting optical waveguides are used to realize a rectangular ring resonator with a multimode interference liquid core coupler between the ring and the bus waveguide. In this...

  • Material Limitations on the Detection Limit in Refractometry. Skafte-Pedersen, Peder; Nunes, Pedro S.; Sanshui Xiao; Mortensen, Niels Asger // Sensors (14248220);2009, Vol. 9 Issue 11, p8382 

    We discuss the detection limit for refractometric sensors relying on high-Q optical cavities and show that the ultimate classical detection limit is given by min {Δn} ≳ η, with n + iη being the complex refractive index of the material under refractometric investigation. Taking...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics