Characterization of sensing capability of optofluidic ring resonator biosensors

Hao Li; Xudong Fan
July 2010
Applied Physics Letters;7/5/2010, Vol. 97 Issue 1, p011105
Academic Journal
The sensing capability of the capillary-based optofluidic ring resonator in bulk refractive index (RI) detection and label-free small molecule detection is investigated. In bulk RI detection, a sensitivity of 570 nm/refractive index units (RIU) is achieved with a Q-factor of 1.2×105. A change of 2.8×10-7 RIU is observed with the noise equivalent detection limit (NEDL) of 3.8×10-8 RIU. In small molecule detection, 10 nM biotin is detected with surface mass density of 1.6 pg/mm2. The NEDL is approximately 0.14 pg/mm2. These results set the benchmark for ring resonator sensing performance and compare very favorably with those obtained with other label-free optical sensors.


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