Estimated birth weight and adult cardiovascular risk factors in a developing southern Chinese population: a cross sectional study

Schooling, C. M.; Jiang, C. Q.; Lam, T. H.; Cowling, B. J.; Yeung, S. L. Au; Zhang, W. S.; Cheng, K. K.; Leung, G. M.
January 2010
BMC Public Health;2010, Vol. 10 Issue 1, p270
Academic Journal
Background: Birth weight is negatively associated with cardiovascular diseases and diabetes, but the associations are less well-established in developing populations where birth weight is often unavailable. We studied the association of birth weight and cardiovascular risk, using birth rank as an instrumental variable, in Southern China. Methods: We used published data on birth weight by birth rank from an appropriate population and baseline data from the Guangzhou Biobank Cohort Study phases 2 & 3 (2005-8) to examine the adjusted associations, using instrumental variable analysis, of birth weight with clinically measured cardiovascular risk factors and the metabolic syndrome in older (⩾ 50 years) men (n = 5,051) and women (n = 13,907). Results: Estimated birth weight was associated with lower blood pressure (systolic -0.25 mm Hg 95% confidence interval (CI), -0.53 to 0.03 and diastolic -0.33 mm Hg 95% CI -0.48 to -0.18 per standard deviation higher birth weight), but had little association with glucose, lipids, waist-hip ratio, body mass index or the metabolic syndrome, adjusted for age, sex, early environment and number of offspring. Conclusion: Birth weight may impact blood pressure; however associations of birth weight with other cardiovascular risk factors may not be related to foetal exposures, but speculatively could be an historical co-incidence, with corresponding implications for prevention.


Related Articles

  • Birth weight, hypertension and ‘white coat’ hypertension: size at birth in relation to office and 24-h ambulatory blood pressure. Koupil, I.; Leon, D. A; Byberg, L. // Journal of Human Hypertension;Aug2005, Vol. 19 Issue 8, p635 

    We investigated the association of size at birth with hypertensive status defined by office blood pressure (BP) and 24-h ambulatory BP monitoring in a historical cohort study of 736 men born 1920–1924 and examined at age 70 years. Office BP was measured after 10-min supine rest with a...

  • Clusters of metabolic risk factors predict cardiovascular events in hypertension with target-organ damage: the LIFE study. de Simone, G.; Olsen, M. H.; Wachtell, K.; Hille, D. A.; Dahlöf, B.; Ibsen, H.; Kjeldsen, S. E.; Lyle, P. A.; Devereux, R. B. // Journal of Human Hypertension;Aug2007, Vol. 21 Issue 8, p625 

    The relation of metabolic syndrome (MetS) with cardiovascular outcome may be less evident when preclinical cardiovascular disease is present. We explored, in a post hoc analysis, whether MetS predicts cardiovascular events in hypertensive patients with electrocardiographic left ventricular...

  • Prevalence of Metabolic Syndrome in a Venezuelan Population by ATPIII vs IDF Criteria Which Were Compared and Associated to Other Cardiovascular Risk Factors. Imperia, E.; Brajkovich, M.; Risquez, Alejandro; Khawan, Rania; Cevallos, Jose Luis; Millan, Angel; Aris-Mendi, Zulay; Benedetti, Paola; Escudero, Pedro; Escuriza, Marian; España, Maria; Gonzalez, Rosalyn; Terrones, Orlando; Olmos, Jose; Urdaneta, Luis; Vergara, Karol; Peña, Naomi; Suarez, Maria; Garcia, Saladina // Diabetes;Jun2007 Supplement 1, Vol. 56, pA636 

    Recognition of the metabolic syndrome (MS) is important to identify individuals who have increased metabolic/cardiovascular risk. Few data about prevalence of Metabolic Syndrome (MS) has been published in Venezuela. This study aims to determine the prevalence of MS and assess concordance between...

  • Relationships of Birthweight and Postnatal Growth with Metabolic Risk Factors in Junior School Children in Korea. Kyoung Ae Kong; Hye Ah Lee; Bo Hyun Park; Jeong Wan Seo; Jee Young Oh; Namsoo Chang; Sun Hwa Lee; Eun Hee Ha; Young Sun Hong; Hyesook Park // Current Hypertension Reviews;Nov2011, Vol. 7 Issue 3, p153 

    We investigated the relationships of birthweight and postnatal growth with the components of metabolic syndrome and their clustering in young schoolchildren in Korea. The subjects comprised 261 children aged 7--9 years who were recruited from an elementary school. Information on birthweight was...

  • Should low birth-weight be considered a relevant risk factor for rise in pulse pressure among adult overweight-obese subjects? Fedi, Anna; Cipollini, Franco; Arcangeli, Enrica; Fabbri, Gianna; Policardo, Laura; Seghieri, Marta; Seghieri, Giuseppe // Italian Journal of Medicine;2015, Vol. 9 Issue 3, p273 

    Low birth-weight (BW) is related to rise in blood pressure (BP) later in life. Aim of this study is investigating whether presence of overweight-obesity modifies this relationship, independently from any additional correlate of metabolic syndrome. We studied 535 (216 M/319 F) otherwise healthy...

  • Salt sensitivity of blood pressure: developmental and sex-related effects. Wesseling, Sebastiaan; Koeners, Maarten P.; Joles, Jaap A. // American Journal of Clinical Nutrition;Dec2011 Supplement, Vol. 94 Issue 6S, p1928S 

    Epidemiologic studies have shown convincingly that drastically reducing salt intake in the community is accompanied by blood pressure reductions that are comparable to those achieved by antihypertensive medication. Moreover, many subjects with hypertension are salt sensitive. This implies that,...

  • Is the Metabolic Syndrome a 'Small Baby' Syndrome?: The Bogalusa Heart Study. Harville, Emily W.; Srinivasan, Sathanur; Chen, Wei; Berenson, Gerald S. // Metabolic Syndrome & Related Disorders;Dec2012, Vol. 10 Issue 6, p413 

    Background: Metabolic syndrome has been called a 'small baby syndrome,' but other analyses suggest that postnatal growth is more important than birthweight, or that large babies are also at risk. The aim of this analysis was to examine whether there was a relationship between both low and high...

  • Relationship of Low Birth Weight to Pulsatile Arterial Function in Asymptomatic Younger Adults: The Bogalusa Heart Study. Bhuiyan, Azad R.; Wei Chen; Srinivasan, Sathanur R.; Azevedo, Mario J.; Berenson, Gerald S. // American Journal of Hypertension;Feb2010, Vol. 23 Issue 2, p168 

    BackgroundLow birth weight, an indictor of intrauterine growth restriction, is associated with adult cardiovascular (CV) disease, type 2 diabetes, and adverse levels of CV risk factors. Impaired pulsatile arterial function is also an independent predictor of early vascular damage and related CV...

  • Growth in utero, blood pressure in childhood and adult life, and mortality from cardiovascular disease. Barker, D.J.P.; Osmond, C.; Golding, J.; Kuh, D.; Wadsworth, M.E.J. // BMJ: British Medical Journal (International Edition);3/4/89, Vol. 298 Issue 6673, p564 

    Reports the relation of systolic blood pressure to birth weight. Details on the influence of intrauterine environment; Discussion on the geographical differences in average blood pressure and mortality from cardiovascular disease; Persistence of geographical differences in the childhood...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics