TITLE

Design of the Anti-tuberculosis Drugs induced Adverse Reactions in China National Tuberculo

AUTHOR(S)
Yin Yin Xia; Dai Yu Hu; Fei Ying Liu; Xiao Meng Wang; Yan Li Yuan; De Hua Tu; Yi Xin Chen; Lin Zhou; Li Zhen Zhu; Wei Wei Gao; Hong Yuan Wang; Da Fang Chen; Li Yang; Ping Ping He; Xiao Ting Li; Ying Jian He; Feng Sun; Si Yan Zhan
PUB. DATE
January 2010
SOURCE
BMC Public Health;2010, Vol. 10, p267
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: More than 1 million tuberculosis (TB) patients are receiving the standard anti-TB treatment provided by China National Tuberculosis Prevention and Control Scheme (CNTS) in China every year. Adverse reactions (ADRs) induced by anti-TB drugs could both do harm to patients and lead to anti-TB treatment failure. The ADACS aimed to explore ADRs' incidences, prognoses, economical and public health impacts for TB patients and TB control, and build a DNA bank of TB patients. Methods/Design: Multiple study designs were adopted. Firstly, a prospective cohort with 4488 sputum smears positive pulmonary tuberculosis patients was established. Patients were followed up for 6-9 months in 52 counties of four regions. Those suspected ADRs should be checked and confirmed by Chinese State Food and Drug Administration (SFDA). Secondly, if the suspected ADR was anti-TB drug induced liver injury (ATLI), a nested case-control study would be performed which comprised choosing a matched control and doing a plus questionnaire inquiry. Thirdly, health economical data of ADRs would be collected to analyze financial burdens brought by ADRs and cost-effectiveness of ADRs' treatments. Fourthly, a drop of intravenous blood for each patient was taken and saved in FTA card for DNA banking and genotyping. Finally, the demographic, clinical, environmental, administrative and genetic data would be merged for the comprehensive analysis. Discussion: ADACS will give an overview of anti-TB drugs induced ADRs' incidences, risk factors, treatments, prognoses, and clinical, economical and public health impacts for TB patients applying CNTS regimen in China, and provide suggestions for individualized health care and TB control policy.
ACCESSION #
52038686

 

Related Articles

  • Ethionamide.  // Reactions Weekly;7/6/2013, Issue 1460, p22 

    The article presents a case study of a 38-year-old man who developed gynaecomastia while receiving ethionamide and antituberculars for the treatment of pulmonary tuberculosis.

  • Prevalence of multidrug resistance among retreatment pulmonary tuberculosis cases in a tertiary care hospital, Hyderabad, India. Kandi, Subhakar; Prasad, Surapaneni Venkateswara; Navaneeth Sagar Reddy, P.; Kishore Reddy, Vennaposa Chenna; Laxmi, Rajya; Kopuu, Dhanamurthy; Kondapaka, Kiran Kumar; Sreenivas Rao, M. S.; Vishnu, P. H. // Lung India; 

    Background: India is one of the high tuberculosis (TB) burden countries in the world. India ranks second in harboring multi drug resistant (MDR)-TB cases. About 50,000 of MDR cases are recorded in retreatment pulmonary TB cases. This study was conducted in a tertiary care facility (Government...

  • Anti-Tuberculosis Drug Resistance among New and Previously Treated Sputum Smear-Positive Tuberculosis Patients in Uganda: Results of the First National Survey. Lukoye, Deus; Adatu, Francis; Musisi, Kenneth; Kasule, George William; Were, Willy; Odeke, Rosemary; Kalamya, Julius Namonyo; Awor, Ann; Date, Anand; Joloba, Moses L. // PLoS ONE;Aug2013, Vol. 8 Issue 8, p1 

    Background: Multidrug resistant and extensively drug resistant tuberculosis (TB) have become major threats to control of tuberculosis globally. The rates of anti-TB drug resistance in Uganda are not known. We conducted a national drug resistance survey to investigate the levels and patterns of...

  • Antituberculosis drug resistance patterns in two regions of Turkey: a retrospective analysis. Kart, Levent; Altin, Remzi; Tor, Meltem; Gulmez, Inci; Oymak, Sema F.; Atmaca, Hulusi M.; Erdem, Funda // Annals of Clinical Microbiology & Antimicrobials;2002, Vol. 1, p6 

    Backround: The emergence of Mycobacterium tuberculosis strains resistant to antituberculosis agents has recently received increased attention owing largely to the dramatic outbreaks of multi drug resistance tuberculosis (MDR-TB). Methods: Patients residing in Zonguldak and Kayseri provinces of...

  • Tuberculous meningitis and resistance to isoniazid. Blomberg, Bjørn; Langeland, Nina // BMJ: British Medical Journal (Overseas & Retired Doctors Edition;9/18/2010, Vol. 341 Issue 7773, p565 

    The authors comment on the study "Isoniazid resistance and death in patients with tuberculous meningitis: retrospective cohort study," by C. Vinnard et al, published within the issue. A brief background on tuberculous meningitis is offered. Findings of the study showed the strong association...

  • Is bronchodilation required routinely before diagnostic sputum induction? Evidence from studies with tuberculosis.  // Thorax;May2008, Vol. 63 Issue 5, p473 

    A letter to the editor is presented which is concerned with research which investigated whether bronchodilation is routinely required before diagnostic sputum induction in patients with tuberculosis.

  • Prueba de cosintropina en tuberculosis activa grave. Casanova-Cardiel, Luis Javier; Flores-Barrientos, Oscar Israel; Schabib-Hany, Muslim; Miranda-Ruiz, Rogelio; Castañón-González, Jorge Alberto // Cirugia y Cirujanos;jul/ago2008, Vol. 76 Issue 4, p305 

    Background: Frequency of adrenal insufficiency in patients with tuberculosis varies from 0 to 58%. Our objective was to investigate adrenal insufficiency with the low-dose cosyntropin test in patients with severe active tuberculosis. Methods: From two large university affiliated hospitals, 18...

  • Multifocal tuberculosis of the nose and lymph nodes without pulmonary involvement: A case report. Kamath, M. Panduranga; Bhojwani, Kiran M.; Prabhu, Shivananda; Naik, Ramdas; Ninan, Geo P.; Chakravarthy, Yeshwanth // ENT: Ear, Nose & Throat Journal;May2007, Vol. 86 Issue 5, p284 

    Tuberculosis of the nose is very rare. When it does occur, it almost always arises secondary to primary pulmonary tuberculosis. Nasal tuberculosis is most common in women older than 20 years. We report the case of a 16-year-old girl who presented with epistaxis, fever, submental swelling, and...

  • Modernizing Surveillance of Antituberculosis Drug Resistance: From Special Surveys to Routine Testing. Zignol, Matteo; van Gemert, Wayne; Falzon, Dennis; Jaramillo, Ernesto; Blanc, L�opold; Raviglione, Mario // Clinical Infectious Diseases;Apr2011, Vol. 52 Issue 7, p901 

    Availability of new diagnostic tools and global commitment towards universal access to tuberculosis care will accelerate capacity of resource-limited countries to monitor anti-tuberculosis drug resistance. Special surveys will be replaced by routine surveillance of drug resistance linked to...

Share

Read the Article

Courtesy of VIRGINIA BEACH PUBLIC LIBRARY AND SYSTEM

Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics