A European project on incidence, treatment, and outcome of sarcoma

Mastrangelo, Giuseppe; Fadda, Emanuela; Cegolon, Luca; Montesco, Maria C.; Ray-Coquard, Isabel; Buja, Alessandra; Fedeli, Ugo; Frasson, Alvise; Spolaore, Paolo; Rossi, Carlo R.
January 2010
BMC Public Health;2010, Vol. 10 Issue 1, p188
Academic Journal
Background: Sarcomas are rare tumors (1-2% of all cancers) of mesenchymal origin that may develop in soft tissues and viscera. Since the International Classification of Disease (ICD) attributes visceral sarcomas (VS) to the organ of origin, the incidence of sarcoma is grossly underestimated. The rarity of the disease and the variety of histological types (more than 70) or locations account for the difficulty in acquiring sufficient personal experience. In view of the above the European Commission funded the project called Connective Tissues Cancers Network (CONTICANET), to improve the prognosis of sarcoma patients by increasing the level of standardization of diagnostic and therapeutic procedures through a multicentre collaboration. Methods/Design: Two protocols of epidemiological researches are here presented. The first investigation aims to build the population-based incidence of sarcoma in a two-year period, using the new 2002 WHO classification and the "second opinion" given by an expert regional pathologist on the initial diagnosis by a local pathologist. A three to five year survival rate will also be determined. Pathology reports and clinical records will be the sources of information. The second study aims to compare the effects on survival or relapse-free period - allowing for histological subtypes, clinical stage, primary site, age and gender - when the disease was treated or not according to the clinical practice guidelines (CPGs). Discussion: Within CONTICANET, each group was asked to design a particular study on a specific objective, the partners of the network being free to accept or not the proposed protocol. The first protocol was accepted by the other researchers, therefore the incidence of sarcoma will be assessed in three European regions, Rhone-Alpes and Aquitaine (France) and Veneto (Italy), where the geographic distribution of sarcoma will be compared after taking into account age and gender. The conformity of the clinical practice with the recommended guidelines will be investigated in a French (Rhone Alps) and Italian (Veneto) region since the CPGs were similar in both areas.


Related Articles

  • Two relatives female patients with primary malignant phyllodes sarcoma and primary stromal sarcoma of breast - A clinical case. Strashilov, Strahil; Yordanov, Angel Danchev; Slavchev, Stanislav; Nanev, Vasil; Ivanova, Denislava; Ivanov, Momchil; Ivanov, Ivan // Australasian Medical Journal;2019, Vol. 12 Issue 9, p251 

    The primary sarcoma of breast is a rare malignant tumour, which develops from the mesenchymal tissue of the mammary gland. It represents less than 1 per cent of all malignant diseases of the breast. The incidence is about 17 new cases per 1 000 000 women. The aetiology of that disease is...

  • Soft tissue sarcoma of the hand or foot: conservative surgery and radiotherapy. Jyothirmayi, Rema; Sittampalam, Yoga; Harmer, Clive // Sarcoma;Mar1999, Vol. 3 Issue 1, p17 

    Purpose . Conservative treatment in the form of limited surgery and post-operative radiotherapy is controversial in hand and foot sarcomas, both due to poor radiation tolerance of the palm and sole, and due to technical difficulties in achieving adequate margins. This paper describes the local...

  • EORTC ABSTRACTS. Steen, Nielsen Ole // Sarcoma;Sep2001, Vol. 5 Issue 3, p157 

    Presents several abstracts published in the September 2001 issue of the journal 'Sarcoma.' 'Evaluation and Presentation of Clinical Trial Data on Sarcomas,' by I. Judson; 'Future Clinical Trial Design of Soft Tissue Sarcoma Studies,' by J. Verweij; 'Molecular Biology and Cytogenetics in the...

  • Mesenchymal Chondrosarcoma: A Small Cell Neoplasm with Polyphenotypic Differentiation. Hoang, Mai P.; Suarez, Patricia A.; Donner, Ludvik R.; Ro, Jae Y; Ordonez, Nelson G.; Ayala, Alberto G.; Czerniak, Bogdan // International Journal of Surgical Pathology;Oct2000, Vol. 8 Issue 4, p291 

    Analyzes the clinicoradiographic, microscopic and immunophenotypic features of 21 tumors from 13 patients with mesenchymal chondrosarcoma neoplasms. Number of patients with primary tumors; Number of patients with metastatic tumors; Clinicopathological data; Radiographic findings; Gross...

  • Atrophic dermatofibrosarcoma protuberans with minimal clinical manifestation. Barreiros, Hugo Marques; Serrano, Pedro Nuno; Parreira, José Carlos; Bártolo, Elvira // Journal of Dermatological Case Reports;2013, Vol. 7 Issue 1, p27 

    Dermatofibrosarcoma protuberans is an uncommon soft tissue neoplasm. In the vast majority of cases it presents as a nodule or a firm tumor that can reach massive dimensions producing the protuberant nodules for which it is named. We report a case of a 34-year-old woman presented at our...

  • The adhesion molecule CD44v6 is associated with a high risk for local recurrence in adult soft tissue sarcomas. Maula, S; Huuhtanen, R L; Blomqvist, C P; Wiklund, T A; Laurila, P; Ristamäki, R // British Journal of Cancer;1/15/2001, Vol. 84 Issue 2, p244 

    In many malignant diseases the expression levels of CD44 and its splice variant v6 (CD44v6) have been associated with the prognosis. The purpose of this study was to investigate the clinical significance of CD44 in adult soft tissue sarcomas (STS). 133 STS patients with a limb or superficial...

  • KSHV/HHV-8 and HIV infection in Kaposi's sarcoma development. Pyakurel, Pawan; Pak, Fatemeh; Mwakigonja, Amos R.; Kaaya, Ephata; Biberfeld, Peter // Infectious Agents & Cancer;2007, Vol. 2, p4 

    Kaposi's sarcoma (KS) is a highly and abnormally vascularized tumor-like lesion affecting the skin, lymphnodes and viscera, which develops from early inflammatory stages of patch/plaque to late, nodular tumors composed predominant of spindle cells (SC). These SC are infected with the Kaposi's...

  • Pattern of local recurrence after conservative surgery and radiotherapy for soft tissue sarcoma. Cleator, Susan J.; Cottrill, Chris; Harmer, Clive // Sarcoma;Jun2001, Vol. 5 Issue 2, p83 

    Purpose: Over the past three decades our centre has adopted a policy of conservative surgery followed by adjuvant radicaldose radiotherapy for medium- and high-grade soft tissue sarcomas. For all cases of local recurrence following this treatment we aimed to define the spatial relationship...

  • Chronic osteomyelitis mimicking sarcoma. Gulmann, C.; Young, O.; Tolan, M.; O'Riordan, D.; Leader, M. // Journal of Clinical Pathology;Mar2003, Vol. 56 Issue 3, p237 

    This report describes a rare case of chronic osteomyelitis in a 60 year old man mimicking a soft tissue sarcoma. Chronic osteomyelitis is an infrequent cause of a soft tissue mass and is usually diagnosed clinically by a combination of radiology and microbiology. Rarely, COM can mimic a primary...


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics