Staying well after depression: trial design and protocol

Williams, J. Mark G.; Russell, Ian T.; Crane, Catherine; Russell, Daphne; Whitaker, Chris J.; Duggan, Danielle S.; Barnhofer, Thorsten; J. V.^Fennell, Melanie; Crane, Rebecca; Silverton, Sarah
January 2010
BMC Psychiatry;2010, Vol. 10, p23
Academic Journal
Background: Depression is often a chronic relapsing condition, with relapse rates of 50-80% in those who have been depressed before. This is particularly problematic for those who become suicidal when depressed since habitual recurrence of suicidal thoughts increases likelihood of further acute suicidal episodes. Therefore the question how to prevent relapse is of particular urgency in this group. Methods/Design: This trial compares Mindfulness-Based Cognitive Therapy (MBCT), a novel form of treatment combining mindfulness meditation and cognitive therapy for depression, with both Cognitive Psycho-Education (CPE), an equally plausible cognitive treatment but without meditation, and treatment as usual (TAU). It will test whether MBCT reduces the risk of relapse in recurrently depressed patients and the incidence of suicidal symptoms in those with a history of suicidality who do relapse. It recruits participants, screens them by telephone for main inclusion and exclusion criteria and, if they are eligible, invites them to a pre-treatment session to assess eligibility in more detail. This trial allocates eligible participants at random between MBCT and TAU, CPE and TAU, and TAU alone in a ratio of 2:2:1, stratified by presence of suicidal ideation or behaviour and current anti-depressant use. We aim to recruit sufficient participants to allow for retention of 300 following attrition. We deliver both active treatments in groups meeting for two hours every week for eight weeks. We shall estimate effects on rates of relapse and suicidal symptoms over 12 months following treatment and assess clinical status immediately after treatment, and three, six, nine and twelve months thereafter. Discussion: This will be the first trial of MBCT to investigate whether MCBT is effective in preventing relapse to depression when compared with a control psychological treatment of equal plausibility; and to explore the use of MBCT for the most severe recurrent depression - that in people who become suicidal when depressed. Trial Registration: Current Controlled Trials: ISRCTN97185214.


Related Articles

  • Offspring and the frequency of intergenerational contacts influence depression among elderly. Kirchengast, Sylvia; Haslinger, Beatrix // Archives: The International Journal of Medicine;Oct-Dec2008, Vol. 1 Issue 4, p163 

    Aim of the study To evaluate the impact of intergenerational contact frequency and number of offspring on the prevalence of depression. Material- Methods The impact of intergenerational contact frequency and number of offspring on the prevalence of depression was tested among 159 healthy...

  • Personality and Depression. Bagby, R. Michael; Quilty, Lena C.; Ryder, Andrew C. // Canadian Journal of Psychiatry;Jan2008, Vol. 53 Issue 1, p14 

    Objective: To examine the implications of the association between personality and depression for the understanding, assessment, and treatment of major depression. Method: A broad range of peer-reviewed manuscripts relevant to personality and depression was reviewed. Particular emphasis was...

  • THE IMPACT OF DOWNWARD SOCIAL COMPARISON PROCESSES ON DEPRESSIVE SYMPTOMS IN OLDER MEN AND WOMEN. Kohn, Steven J.; Smith, Gregory C. // Ageing International;Winter2003, Vol. 28 Issue 1, p37 

    Most older people maintain good mental health despite numerous age-related changes to their physical health and functional abilities. Although it is widely believed that making downward social comparisons is a strategy used by older adults to protect their psychological well-being against...

  • Sri Lankan doctors’ and medical undergraduates’ attitudes towards mental illness. Fernando, Sunera Mayanthi; Deane, Frank P.; McLeod, Hamish J. // Social Psychiatry & Psychiatric Epidemiology;Jul2010, Vol. 45 Issue 7, p733 

    Stigmatizing attitudes towards mental illness can impede help-seeking and adversely affect treatment outcomes, especially if such attitudes are endorsed by medical personnel. In order to help identify targets for anti-stigma interventions, we comprehensively examined negative attitudes towards...

  • THE DEPRESSED PATIENT. MacDonald, Pat // Practice Nurse;10/29/2004, Vol. 28 Issue 7, p32 

    Presents information on depression. Causes of depression; Symptoms; Treatments; Approach in discussing depression with patients.

  • Predictors of Recurrent Sickness Absence Due to Depressive Disorders - A Delphi Approach Involving Scientists and Physicians. Norder, Giny; Roelen, Corné A. M.; van Rhenen, Willem; Buitenhuis, Jan; Bültmann, Ute; Anema, Johannes R. // PLoS ONE;Dec2012, Vol. 7 Issue 12, p1 

    Background: Depression is a common and highly recurrent mental disorder that is accompanied by poor functioning at home and at work. Not all depressed employees report sick and little is known about variables associated with sickness absence (SA) due to depression. Recurrent SA due to depression...

  • Thoughts of death or suicidal ideation are common in young people aged 12 to 30 years presenting for mental health care. Scott, Elizabeth M; Hermens, Daniel F; Naismith, Sharon L; White, Django; Whitwell, Bradley; Guastella, Adam J; Glozier, Nick; Hickie, Ian B // BMC Psychiatry;2012, Vol. 12 Issue 1, p234 

    Background: Reducing suicidal behaviour is a major public health goal. Expanding access to care has been identified as a key strategy. In Australia, a national network of primary-care based services (headspace) has been established for young people with mental ill-health. This study determines...

  • Gender Differences in Anxiety and Depression Among Immigrant Latinos. Hiott, Ann; Grzywacz, Joseph G.; Arcury, Thomas A.; Quandt, Sara A. // Families, Systems & Health: The Journal of Collaborative Family ;Summer2006, Vol. 24 Issue 2, p137 

    This study determines elements of a social history that could assist primary care providers in identifying and treating anxiety and depression among immigrant Mexicans. Cross-sectional data were obtained through interviewer-administered survey questionnaires from immigrant Latinos in the United...

  • Identification of Depression with Atypical Features. Miller, Karl E. // American Family Physician;2/15/2004, Vol. 69 Issue 4, p973 

    Discusses research being done on patients with atypical depression. Reference to a study by L.S. Matza et al published in the August 2003 issue of "Archives General Psychiatry"; Description of atypical depression; Markers for atypical mental depression.


Read the Article


Sorry, but this item is not currently available from your library.

Try another library?
Sign out of this library

Other Topics