TITLE

Curcumin reduces α-synuclein induced cytotoxicity in Parkinson's disease cell model

AUTHOR(S)
Wang, Min S.; Boddapati, Shanta; Emadi, Sharareh; Sierks, Michael R.
PUB. DATE
January 2010
SOURCE
BMC Neuroscience;2010, Vol. 11, p57
SOURCE TYPE
Academic Journal
DOC. TYPE
Article
ABSTRACT
Background: Overexpression and abnormal accumulation of aggregated a-synuclein (aS) have been linked to Parkinson's disease (PD) and other synucleinopathies. aS can misfold and adopt a variety of morphologies but recent studies implicate oligomeric forms as the most cytotoxic species. Both genetic mutations and chronic exposure to neurotoxins increase aS aggregation and intracellular reactive oxygen species (ROS), leading to mitochondrial dysfunction and oxidative damage in PD cell models. Results: Here we show that curcumin can alleviate aS-induced toxicity, reduce ROS levels and protect cells against apoptosis. We also show that both intracellular overexpression of aS and extracellular addition of oligomeric aS increase ROS which induces apoptosis, suggesting that aggregated aS may induce similar toxic effects whether it is generated intra- or extracellulary. Conclusions: Since curcumin is a natural food pigment that can cross the blood brain barrier and has widespread medicinal uses, it has potential therapeutic value for treating PD and other neurodegenerative disorders.
ACCESSION #
52008862

 

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